Professor | Yan Shen | Asia Growth Partners

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Name	Yan Shen
Contact Information	shenyan@nju.edu.cn
Language ability	Chinese, English, Japanese
Province	Jiangsu

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Name

Yan Shen

Contact Information

shenyan@nju.edu.cn

Language ability

Chinese, English, Japanese

Province

Jiangsu

University/Lab Affiliation and Title	Nanjing University
Faculty	Life Sciences
Academic Background & Achievements	1992.09–1997.07 Bachelor: Shenyang Pharmaceutical University 1997.09–2000.06 Master: Shenyang Pharmaceutical University 2000.10–2005.05 Doctorate: Yokohama City University, Japan Received the First Prize of the Natural Science Award for Outstanding Scientific Research Achievements in Higher Education Institutions twice
Work Experience	2005.09–2007.12 Nanjing University, School of Life Sciences - Lecturer 2007.12–Present Nanjing University, School of Life Sciences - Associate Professor 2011.11–2012.11 Kyoto University, Japan - Visiting Scholar 2019.11–2020.12 University of Pennsylvania, Perelman School of Medicine, USA - Visiting Scholar
Awards	2010: Nanjing University Young Backbone Teacher 2011: Jiangsu Province Teaching Achievement Award Second Prize 2012: First Prize of the Natural Science Award for Outstanding Scientific Research Achievements in Higher Education Institutions (9/11) 2015: Nanjing University Bank of China Young Teacher Achievement First Prize 2019: First Prize of the Natural Science Award for Outstanding Scientific Research Achievements in Higher Education Institutions (7/8) 2020: National First-Class Undergraduate Course

University/Lab Affiliation and Title

Nanjing University

Faculty

Life Sciences

Academic Background & Achievements

1992.09–1997.07 Bachelor: Shenyang Pharmaceutical University
1997.09–2000.06 Master: Shenyang Pharmaceutical University
2000.10–2005.05 Doctorate: Yokohama City University, Japan
Received the First Prize of the Natural Science Award for Outstanding Scientific Research Achievements in Higher Education Institutions twice

Work Experience

2005.09–2007.12 Nanjing University, School of Life Sciences - Lecturer
2007.12–Present Nanjing University, School of Life Sciences - Associate Professor
2011.11–2012.11 Kyoto University, Japan - Visiting Scholar
2019.11–2020.12 University of Pennsylvania, Perelman School of Medicine, USA - Visiting Scholar

Awards

2010: Nanjing University Young Backbone Teacher
2011: Jiangsu Province Teaching Achievement Award Second Prize
2012: First Prize of the Natural Science Award for Outstanding Scientific Research Achievements in Higher Education Institutions (9/11)
2015: Nanjing University Bank of China Young Teacher Achievement First Prize
2019: First Prize of the Natural Science Award for Outstanding Scientific Research Achievements in Higher Education Institutions (7/8)
2020: National First-Class Undergraduate Course

Areas of Focus	Research on tumor malignant progression and drug resistance mechanisms Identification and mechanism of action of small molecule compounds with anti-tumor activity Research on the pathogenesis of immune diseases and development of therapeutic drugs
Publications	Therapeutic effect of CpG-enriched plasmid administration on the tight-skin mouse model of scleroderma., Yan Shen, Motohide Ichino, Masatoshi Nakazawa, Takashi Ikejima, Yoshitsugu Kojima, Kenji Okuda, and Mutsuhiko Minami, 2005 CpG oligodeoxynucleotides prevent the development of scleroderma-like syndrome in tight-skin mice by stimulating a Th1 immune response., Yan Shen, Motohide Ichino, Masatoshi Nakazawa, and Mutsuhiko Minami, 2005 PRL-3 promotes the malignant progression of melanoma via triggering dephosphorylation and cytoplasmic localization of NHERF1., Fang XY, Song R, Chen W, Yang YY, Gu YH, Shu YQ, Wu XD, Wu XF, Sun Y, Shen Y, Xu Q, 2015 Blockade of the interaction between Bcr-Abl and PTB1B by small molecule SBF-1 to overcome imatinib-resistance of chronic myeloid leukemia cells., Elgehama, A. Chen W, Pang J, Mi S, Li J, Guo W, Wang X, Gao J, Yu B, Shen Y, Xu Q, 2016 Small molecule RL71-triggered excessive autophagic cell death as a potential therapeutic strategy in triple-negative breast cancer., Gao J, Fan M, Peng S, Zhang M, Xiang G, Li X, Guo W, Sun Y, Wu X, Wu X, Liang G, Shen Y, Xu Q, 2017 Exosomal transfer of cisplatin-induced miR-425-3p confers cisplatin resistance in NSCLC through activating autophagy., Ma Y, Yuwen D, Chen JW, Zheng BF, Gao J, Fan M, Xue WW, Wang YX, Li WH, Shu Y, Xu Q, Shen Y, 2019 Triggering a switch from basal- to luminal-like breast cancer subtype by the small-molecule diptoindonesin G via induction of GABARAPL1., Fan M, Chen JW, Gao J, Xue WW, Wang YX, Li WH, Zhou L, Li X, Jiang CF, Sun Y, Wu XF, Wu XD, Ge H, Shen Y, Xu Q, 2020 Intracellular CYTL1, a novel tumor suppressor, stabilizes NDUFV1 to inhibit metabolic reprogramming in breast cancer., Xue WW, Li X, Li WH, Wang YX, Jiang CF, Zhou L, Gao J, Yu Y, Shen Y, Xu Q, 2022 Highly expressed SERCA2 triggers tumor cell autophagy and is a druggable vulnerability in triple-negative breast cancer., Fan M, Gao J, Zhou L, Xue WW, Wang YX, Chen JW, Li WH, Yu Y, Liu B, Shen Y, Xu Q, 2022 A plant-derived glucocorticoid receptor modulator with potency to attenuate the side effects of glucocorticoid therapy., Wang YX, Gao J, Yu Y, Zhou L, Miao W, Xue WW, Liu B, Wu XD, Wu XF, Gao HY, Shen Y, Xu Q, 2023

Areas of Focus

Research on tumor malignant progression and drug resistance mechanisms
Identification and mechanism of action of small molecule compounds with anti-tumor activity
Research on the pathogenesis of immune diseases and development of therapeutic drugs

Publications

Therapeutic effect of CpG-enriched plasmid administration on the tight-skin mouse model of scleroderma., Yan Shen, Motohide Ichino, Masatoshi Nakazawa, Takashi Ikejima, Yoshitsugu Kojima, Kenji Okuda, and Mutsuhiko Minami, 2005
CpG oligodeoxynucleotides prevent the development of scleroderma-like syndrome in tight-skin mice by stimulating a Th1 immune response., Yan Shen, Motohide Ichino, Masatoshi Nakazawa, and Mutsuhiko Minami, 2005
PRL-3 promotes the malignant progression of melanoma via triggering dephosphorylation and cytoplasmic localization of NHERF1., Fang XY, Song R, Chen W, Yang YY, Gu YH, Shu YQ, Wu XD, Wu XF, Sun Y*, Shen Y*, Xu Q*, 2015
Blockade of the interaction between Bcr-Abl and PTB1B by small molecule SBF-1 to overcome imatinib-resistance of chronic myeloid leukemia cells., Elgehama, A. Chen W, Pang J, Mi S, Li J, Guo W, Wang X, Gao J, Yu B, Shen Y*, Xu Q*, 2016
Small molecule RL71-triggered excessive autophagic cell death as a potential therapeutic strategy in triple-negative breast cancer., Gao J, Fan M, Peng S, Zhang M, Xiang G, Li X, Guo W, Sun Y, Wu X, Wu X, Liang G, Shen Y*, Xu Q*, 2017
Exosomal transfer of cisplatin-induced miR-425-3p confers cisplatin resistance in NSCLC through activating autophagy., Ma Y, Yuwen D, Chen JW, Zheng BF, Gao J, Fan M, Xue WW, Wang YX, Li WH, Shu Y, Xu Q*, Shen Y*, 2019
Triggering a switch from basal- to luminal-like breast cancer subtype by the small-molecule diptoindonesin G via induction of GABARAPL1., Fan M, Chen JW, Gao J, Xue WW, Wang YX, Li WH, Zhou L, Li X, Jiang CF, Sun Y, Wu XF, Wu XD, Ge H, Shen Y*, Xu Q*, 2020
Intracellular CYTL1, a novel tumor suppressor, stabilizes NDUFV1 to inhibit metabolic reprogramming in breast cancer., Xue WW, Li X, Li WH, Wang YX, Jiang CF, Zhou L, Gao J, Yu Y, Shen Y*, Xu Q*, 2022
Highly expressed SERCA2 triggers tumor cell autophagy and is a druggable vulnerability in triple-negative breast cancer., Fan M, Gao J, Zhou L, Xue WW, Wang YX, Chen JW, Li WH, Yu Y, Liu B, Shen Y*, Xu Q*, 2022
A plant-derived glucocorticoid receptor modulator with potency to attenuate the side effects of glucocorticoid therapy., Wang YX, Gao J, Yu Y, Zhou L, Miao W, Xue WW, Liu B, Wu XD, Wu XF, Gao HY*, Shen Y*, Xu Q*, 2023

Tumor Malignant Progression Drug Resistance Mechanisms Small Molecules Anti-Tumor Immune Diseases Therapeutic Drugs Pathogenesis

Chenhui Wang - Huazhong University of Science and Technology

Chao Yan - Nanjing University

Qinxi Li - Xiamen University

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