Professor | Qinxi Li | Asia Growth Partners

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Name	Qinxi Li
Contact Information	liqinxi@xmu.edu.cn
Language ability	English, Chinese
Province	Fujian

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Name

Qinxi Li

Contact Information

liqinxi@xmu.edu.cn

Language ability

English, Chinese

Province

Fujian

University/Lab Affiliation and Title	Xiamen University
Faculty	Life Sciences
Academic Background & Achievements	1995 - B.S. in Clinical Medicine: Lanzhou Medical College 1998 - M.S. in Clinical Hematology: Lanzhou Medical College 2001 - Ph.D. in Inorganic Chemistry: Lanzhou University 2000 - Second Prize, Fudan University Tan Jiazhen Foundation Life Science Jiuyuan Scholarship 2009 - Selected for the Ministry of Education's New Century Excellent Talents Support Program 2009 - Fujian Natural Science Foundation Outstanding Youth Fund Recipient 2017 - Special Prize, Fujian Higher Education Teaching Achievement Award 2018 - Second Prize, National Higher Education Teaching Achievement Award 2019 - Baosteel Excellent Teacher Award 2020 - Special Prize, Fujian Higher Education Teaching Achievement Award
Work Experience	2001 to Present - Xiamen University, School of Life Sciences - Assistant Professor/Associate Professor/Professor 2017 to Present - Xiamen University, School of Life Sciences - Vice Dean 2003-2005 - Hong Kong University of Science and Technology - Visiting Scholar 2010-2011 - University of Toronto - Postdoc Fellow
Awards	2000 - Second Prize, Fudan University Tan Jiazhen Foundation Life Science Jiuyuan Scholarship 2009 - Selected for the Ministry of Education's New Century Excellent Talents Support Program 2009 - Fujian Natural Science Foundation Outstanding Youth Fund Recipient 2017 - Special Prize, Fujian Higher Education Teaching Achievement Award 2018 - Second Prize, National Higher Education Teaching Achievement Award 2019 - Baosteel Excellent Teacher Award 2020 - Special Prize, Fujian Higher Education Teaching Achievement Award

University/Lab Affiliation and Title

Xiamen University

Faculty

Life Sciences

Academic Background & Achievements

1995 - B.S. in Clinical Medicine: Lanzhou Medical College
1998 - M.S. in Clinical Hematology: Lanzhou Medical College
2001 - Ph.D. in Inorganic Chemistry: Lanzhou University
2000 - Second Prize, Fudan University Tan Jiazhen Foundation Life Science Jiuyuan Scholarship
2009 - Selected for the Ministry of Education's New Century Excellent Talents Support Program
2009 - Fujian Natural Science Foundation Outstanding Youth Fund Recipient
2017 - Special Prize, Fujian Higher Education Teaching Achievement Award
2018 - Second Prize, National Higher Education Teaching Achievement Award
2019 - Baosteel Excellent Teacher Award
2020 - Special Prize, Fujian Higher Education Teaching Achievement Award

Work Experience

2001 to Present - Xiamen University, School of Life Sciences - Assistant Professor/Associate Professor/Professor
2017 to Present - Xiamen University, School of Life Sciences - Vice Dean
2003-2005 - Hong Kong University of Science and Technology - Visiting Scholar
2010-2011 - University of Toronto - Postdoc Fellow

Awards

2000 - Second Prize, Fudan University Tan Jiazhen Foundation Life Science Jiuyuan Scholarship
2009 - Selected for the Ministry of Education's New Century Excellent Talents Support Program
2009 - Fujian Natural Science Foundation Outstanding Youth Fund Recipient
2017 - Special Prize, Fujian Higher Education Teaching Achievement Award
2018 - Second Prize, National Higher Education Teaching Achievement Award
2019 - Baosteel Excellent Teacher Award
2020 - Special Prize, Fujian Higher Education Teaching Achievement Award

Areas of Focus	Mechanisms underlying tumorigenesis driven by isocitrate dehydrogenase 1 (IDH1) R132H/Q mutations The roles of metabolic alterations caused by proto-oncogene c-src in tumorigenesis and metastasis The roles of Glutaminase 1 (GLS1) in nutrient stress, tumorigenesis and organ development The novel mechanisms underlying metabolic regulation by p53
Publications	Filamentous GLS1 promotes ROS-induced apoptosis upon glutamine deprivation via insufficient asparagine synthesis, Jiang B, Zhang J, Zhao G, Liu M, Hu J, Lin F, Wang J, Zhao W, Ma H, Zhang C, Wu C, Yao L, Liu Q, Chen X, Cao Y, Zheng Y, Zhang C, Han A, Lin D, Li Q, 2022 ZEB1 enhances Warburg effect to facilitate tumorigenesis and metastasis of HCC by transcriptionally activating PFKM, Zhou Y, Lin F, Wan T, Chen Ai, Wang H, Jiang B, Zhao W, Liao S, Wang S, Li G, Xu Z, Wang J, Zhang J, Ma H, Lin D, Li Q, 2021 c-Src facilitates tumorigenesis by phosphorylating and activating G6PD, Ma H, Zhang F, Zhou L, Cao T, Sun D, Wen S, Zhu J, Xiong Z, Tsau M-T, Cheng M-L, Hung L-M, Zhou Y, Li Q, 2021 c-Src Promotes Tumorigenesis and Tumor Progression by Activating PFKFB3, Ma H, Zhang J, Zhou L, Wen S, Tang HY, Jiang B, Zhang F, Suleman M, Sun D, Chen A, Zhao W, Lin F, Tsau MT, Shih LM, Xie C, Li X, Lin D, Hung LM, Cheng ML, Li Q, 2020 PIR promotes tumorigenesis of breast cancer by upregulating cell cycle activator E2F1, Suleman M, Chen A, Ma H, Wen S, Zhao W, Lin D, Wu G, Li Q, 2019 IDH1 R132 mutant promotes tumor formation through downregulating p53, Jiang B, Zhao W, Shi M, Zhang J, Chen A, Ma H, Suleman M, Lin F, Zhou L, Wang J, Zhang Y, Liu M, Wen S, Ouyang C, Wang H, Huang X, Zhou H, Li Q, 2018 2-HG Inhibits Necroptosis by Stimulating DNMT1-Dependent Hypermethylation of the RIP3 Promoter, Yang Z, Jiang B, Wang Y, Ni H, Zhang J, Xia J, Shi M, Hung L-M, Ruan J, Mak TW, Li Q and Han J, 2017 IDH1 Mutation Promotes Tumorigenesis by Inhibiting JNK Activation and Apoptosis Induced by Serum Starvation, Jiang B, Zhang J, Xia J, Zhao W, Wu Y, Shi M, Luo L, Zhou H, Chen A, Ma H, Zhao Q, Suleman M, Lin F, Zhou L, Wang J, Zhang Y, He Y, Li X, Hung LM, Mak TW, Li Q, 2017 c-Src phosphorylation and activation of hexokinase promotes tumorigenesis and metastasis, Zhang J, Wang S, Jiang B, Huang L, Ji Z, Li X, Zhou H, Han A, Chen A, Wu Y, Ma H, Zhao W, Zhao Q, Xie C, Sun X, Zhou Y, Huang H, Suleman M, Lin F, Zhou L, Tian F, Jin M, Cai Y, Zhang N, Li Q, 2017 Mutant IDH1 Downregulates ATM and Alters DNA Repair and Sensitivity to DNA Damage Independent of TET2, Inoue S, Li WY, Tseng A, Beerman I, Elia AJ, Bendall SC, Lemonnier F, Kron KJ, Cescon DW, Hao Z, Lind EF, Takayama N, Planello AC, Shen SY, Shih AH, Larsen DM, Li Q, Snow BE, Wakeham A, Haight J, Gorrini C, Bassi C, Thu KL, Murakami K, Elford AR, Ueda T, Straley K, Yen KE, Melino G, Cimmino L, Aifantis I, Levine RL, De Carvalho DD, Lupien M, Rossi DJ, Nolan GP, Cairns RA, Mak TW, 2016 C-terminus of MUC16 activates Wnt signaling pathway through its interaction with β-catenin to promote tumorigenesis and metastasis, Liu Q, Cheng Z, Luo L, Yang Y, Zhang Z, Ma H, Chen T, Huang X, Lin S-Y, Jin M, Li Q, Li X, 2016 Clnk plays a role in TNF-alpha-induced cell death in murine fibrosarcoma cell line, Xu M, Cai C1, Sun X, Chen W, Li Q, Zhou H, 2015 MDM2 Inhibits Axin-induced p53 Activation Independently of Its E3 Ligase Activity, Ying He, Guili Lian, Shuyong Lin, Zhiyun Ye, Qinxi Li, 2013 The Axin/TNKS complex interacts with KIF3A and is required for insulin-stimulated GLUT4 translocation, Guo HL, Zhang C, Liu Q, Li Q, Lian G, Wu D, Li X, Zhang W, Shen Y, Ye Z, Lin SY, Lin SC, 2012 GSK3-TIP60-ULK1 signaling pathway links growth factor deprivation to autophagy, Lin SY, Li TY, Liu Q, Zhang C, Li X, Chen Y, Zhang SM, Lian G, Liu Q, Ruan K, Wang Z, Zhang CS, Chien KY, Wu J, Li Q, Han J, Lin SC, 2012 AXIN is an essential co-activator for the promyelocytic leukemia protein in p53 activation, Li Q, He Y, Wei L, Wu X, Wu D, Lin S, Wang Z, Ye Z, Lin SC, 2011 Axin determines cell fates by controlling p53 activation threshold upon DNA damage, Li Q, Lin S, Wang X, Lian G, Lu Z, Guo H, Ruan K, Wang Y, Ye Z, Han J, Lin SC, 2009 Gelsolin, but not its cleavage, is required for TNF-induced ROS generation and apoptosis in MCF-7 cells, Li Q, Ye Z, Wen J, Ma L, He Y, Lian G, Wang Z, Wei L, Wu D, Jiang B, 2009 Cytosporone B is anagonist for nuclear orphan receptor Nur77, Zhan Y, Du X, Chen H, Liu J, Zhao B, Huang D, Li G, Xu Q, Zhang M, Weimer BC, Chen D, Cheng Z, Zhang L, Li Q, Li S, Zheng Z, Song S, Huang Y, Ye Z, Su W, Lin SC, Shen Y, Wu Q, 2008 Determinants that control the distinct subcellular localization of p38α-PRAK and p38β-PRAK complexes, Li Q, Zhang N, Zhang D, Wang Y, Lin T, Wang Y, Zhou H, Ye Z, Zhang F, Lin SC, Han J, 2008 Daxx Cooperates with the Axin/HIPK2/p53 Complex to Induce Cell Death, Li Q, Wang X, Wu X, Rui Y, Liu W, Wang J, Wang X, Liou Y-C, Ye Z, Lin SC, 2007 Axin bridges Daxx to p53, Lin SC, Li QX, 2007 Differential requirement of MKK4 and MKK7 in JNK activation by distinct scaffold proteins, Zou H, Li Q, Lin SC, Wu Z, Han J, Ye Z, 2007 beta-actin is required for mitochondria clustering and ROS generation in TNF-induced, caspase-independent cell death, Li J, Li Q*, Xie C, Zhou H, Wang Y, Zhang N, Shao H, Chan SC, Peng X, Lin SC, Han J, 2004 Axin stimulates p53 functions by activation of HIPK2 kinase through multimeric complex formation, Rui Y, Xu Z, Lin S, Li Q, Rui H, Luo W, Zhou H, Cheung P, Wu Z, Ye Z, Li P, Han J, Lin SC, 2004

Areas of Focus

Mechanisms underlying tumorigenesis driven by isocitrate dehydrogenase 1 (IDH1) R132H/Q mutations
The roles of metabolic alterations caused by proto-oncogene c-src in tumorigenesis and metastasis
The roles of Glutaminase 1 (GLS1) in nutrient stress, tumorigenesis and organ development
The novel mechanisms underlying metabolic regulation by p53

Publications

Filamentous GLS1 promotes ROS-induced apoptosis upon glutamine deprivation via insufficient asparagine synthesis, Jiang B, Zhang J, Zhao G, Liu M, Hu J, Lin F, Wang J, Zhao W, Ma H, Zhang C, Wu C, Yao L, Liu Q, Chen X, Cao Y, Zheng Y, Zhang C, Han A, Lin D, Li Q*, 2022
ZEB1 enhances Warburg effect to facilitate tumorigenesis and metastasis of HCC by transcriptionally activating PFKM, Zhou Y, Lin F, Wan T, Chen Ai, Wang H, Jiang B, Zhao W, Liao S, Wang S, Li G, Xu Z, Wang J, Zhang J, Ma H, Lin D, Li Q*, 2021
c-Src facilitates tumorigenesis by phosphorylating and activating G6PD, Ma H, Zhang F, Zhou L, Cao T, Sun D, Wen S, Zhu J, Xiong Z, Tsau M-T, Cheng M-L, Hung L-M, Zhou Y, Li Q*, 2021
c-Src Promotes Tumorigenesis and Tumor Progression by Activating PFKFB3, Ma H, Zhang J, Zhou L, Wen S, Tang HY, Jiang B, Zhang F, Suleman M, Sun D, Chen A, Zhao W, Lin F, Tsau MT, Shih LM, Xie C, Li X, Lin D, Hung LM*, Cheng ML*, Li Q*, 2020
PIR promotes tumorigenesis of breast cancer by upregulating cell cycle activator E2F1, Suleman M, Chen A, Ma H, Wen S, Zhao W, Lin D, Wu G*, Li Q*, 2019
IDH1 R132 mutant promotes tumor formation through downregulating p53, Jiang B, Zhao W, Shi M, Zhang J, Chen A, Ma H, Suleman M, Lin F, Zhou L, Wang J, Zhang Y, Liu M, Wen S, Ouyang C, Wang H, Huang X*, Zhou H*, Li Q*, 2018
2-HG Inhibits Necroptosis by Stimulating DNMT1-Dependent Hypermethylation of the RIP3 Promoter, Yang Z, Jiang B, Wang Y, Ni H, Zhang J, Xia J, Shi M, Hung L-M, Ruan J, Mak TW, Li Q* and Han J*, 2017
IDH1 Mutation Promotes Tumorigenesis by Inhibiting JNK Activation and Apoptosis Induced by Serum Starvation, Jiang B, Zhang J, Xia J, Zhao W, Wu Y, Shi M, Luo L, Zhou H, Chen A, Ma H, Zhao Q, Suleman M, Lin F, Zhou L, Wang J, Zhang Y, He Y, Li X, Hung LM, Mak TW, Li Q*, 2017
c-Src phosphorylation and activation of hexokinase promotes tumorigenesis and metastasis, Zhang J, Wang S, Jiang B, Huang L, Ji Z, Li X, Zhou H, Han A, Chen A, Wu Y, Ma H, Zhao W, Zhao Q, Xie C, Sun X, Zhou Y, Huang H, Suleman M, Lin F, Zhou L, Tian F, Jin M, Cai Y, Zhang N, Li Q*, 2017
Mutant IDH1 Downregulates ATM and Alters DNA Repair and Sensitivity to DNA Damage Independent of TET2, Inoue S, Li WY, Tseng A, Beerman I, Elia AJ, Bendall SC, Lemonnier F, Kron KJ, Cescon DW, Hao Z, Lind EF, Takayama N, Planello AC, Shen SY, Shih AH, Larsen DM, Li Q, Snow BE, Wakeham A, Haight J, Gorrini C, Bassi C, Thu KL, Murakami K, Elford AR, Ueda T, Straley K, Yen KE, Melino G, Cimmino L, Aifantis I, Levine RL, De Carvalho DD, Lupien M, Rossi DJ, Nolan GP, Cairns RA, Mak TW, 2016
C-terminus of MUC16 activates Wnt signaling pathway through its interaction with β-catenin to promote tumorigenesis and metastasis, Liu Q, Cheng Z, Luo L, Yang Y, Zhang Z, Ma H, Chen T, Huang X, Lin S-Y, Jin M, Li Q*, Li X*, 2016
Clnk plays a role in TNF-alpha-induced cell death in murine fibrosarcoma cell line, Xu M, Cai C1, Sun X, Chen W, Li Q*, Zhou H*, 2015
MDM2 Inhibits Axin-induced p53 Activation Independently of Its E3 Ligase Activity, Ying He, Guili Lian, Shuyong Lin, Zhiyun Ye, Qinxi Li*, 2013
The Axin/TNKS complex interacts with KIF3A and is required for insulin-stimulated GLUT4 translocation, Guo HL, Zhang C, Liu Q, Li Q, Lian G, Wu D, Li X, Zhang W, Shen Y, Ye Z, Lin SY, Lin SC, 2012
GSK3-TIP60-ULK1 signaling pathway links growth factor deprivation to autophagy, Lin SY, Li TY, Liu Q, Zhang C, Li X, Chen Y, Zhang SM, Lian G, Liu Q, Ruan K, Wang Z, Zhang CS, Chien KY, Wu J, Li Q, Han J, Lin SC, 2012
AXIN is an essential co-activator for the promyelocytic leukemia protein in p53 activation, Li Q, He Y, Wei L, Wu X, Wu D, Lin S, Wang Z, Ye Z, Lin SC, 2011
Axin determines cell fates by controlling p53 activation threshold upon DNA damage, Li Q, Lin S, Wang X, Lian G, Lu Z, Guo H, Ruan K, Wang Y, Ye Z, Han J, Lin SC, 2009
Gelsolin, but not its cleavage, is required for TNF-induced ROS generation and apoptosis in MCF-7 cells, Li Q, Ye Z, Wen J, Ma L, He Y, Lian G, Wang Z, Wei L, Wu D, Jiang B, 2009
Cytosporone B is anagonist for nuclear orphan receptor Nur77, Zhan Y, Du X, Chen H, Liu J, Zhao B, Huang D, Li G, Xu Q, Zhang M, Weimer BC, Chen D, Cheng Z, Zhang L, Li Q, Li S, Zheng Z, Song S, Huang Y, Ye Z, Su W, Lin SC, Shen Y, Wu Q, 2008
Determinants that control the distinct subcellular localization of p38α-PRAK and p38β-PRAK complexes, Li Q, Zhang N, Zhang D, Wang Y, Lin T, Wang Y, Zhou H, Ye Z, Zhang F, Lin SC, Han J, 2008
Daxx Cooperates with the Axin/HIPK2/p53 Complex to Induce Cell Death, Li Q, Wang X, Wu X, Rui Y, Liu W, Wang J, Wang X, Liou Y-C, Ye Z, Lin SC, 2007
Axin bridges Daxx to p53, Lin SC, Li QX, 2007
Differential requirement of MKK4 and MKK7 in JNK activation by distinct scaffold proteins, Zou H, Li Q*, Lin SC, Wu Z, Han J, Ye Z*, 2007
beta-actin is required for mitochondria clustering and ROS generation in TNF-induced, caspase-independent cell death, Li J, Li Q*, Xie C, Zhou H, Wang Y, Zhang N, Shao H, Chan SC, Peng X, Lin SC, Han J, 2004
Axin stimulates p53 functions by activation of HIPK2 kinase through multimeric complex formation, Rui Y, Xu Z, Lin S, Li Q, Rui H, Luo W, Zhou H, Cheung P, Wu Z, Ye Z, Li P, Han J, Lin SC, 2004

Idh1 Mutations Tumorigenesis Glioma 2-Hg Metabolic Disorders Apoptosis Cancer Metabolism Oncogene C-Src Warburg Effect Gls1 Glutamine Catabolism Tumor Therapy Nutrient Stress Organ Development Enzyme Activity Cell Death Small Molecules Anti-Tumor P53 Tumor Suppressor Biosynthesis Lipid Metabolism Cancer Cells Metabolic Regulation Tumor Incidence P53 Deficiency Metabolic Switch Tumor Growth

Jihui Zhang - University of Chinese Academy of Sciences

Yan Shen - Nanjing University

Chao Yan - Nanjing University

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