Professor | Shaochun Yuan | Asia Growth Partners

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Name	Shaochun Yuan
Contact Information	yuanshch@mail.sysu.edu.cn
Language ability	Chinese, English
Province	Guangdong

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Name

Shaochun Yuan

Contact Information

yuanshch@mail.sysu.edu.cn

Language ability

Chinese, English

Province

Guangdong

University/Lab Affiliation and Title	Sun Yat-Sen University
Faculty	Life Sciences
Academic Background & Achievements	1999.09~2003.07: Bachelor of Science, Sun Yat-sen University 2003.09~2008.06: Doctor of Science, Sun Yat-sen University 2007.10~2008.04: Visiting Scholar, Scripps Institution of Oceanography, University of California, San Diego Discovered highly conserved nucleic acid recognition receptors such as ZNFX1, DDX23, Apaf-1 Published over 50 papers in journals like Cell, Nat Cell Biol, J Clin Invest
Work Experience	2008.07~2010.12: Postdoctoral Fellow, Sun Yat-sen University 2011.01~2015.12: Associate Professor, Sun Yat-sen University 2016.01~Present: Professor, Sun Yat-sen University
Awards	2010: China's Top Ten Scientific and Technological Progress in Higher Education 2016: China's Top Ten Advances in Life Sciences National Natural Science Award Second Prize Guangdong Provincial Natural Science Award First Prize

University/Lab Affiliation and Title

Sun Yat-Sen University

Faculty

Life Sciences

Academic Background & Achievements

1999.09~2003.07: Bachelor of Science, Sun Yat-sen University
2003.09~2008.06: Doctor of Science, Sun Yat-sen University
2007.10~2008.04: Visiting Scholar, Scripps Institution of Oceanography, University of California, San Diego
Discovered highly conserved nucleic acid recognition receptors such as ZNFX1, DDX23, Apaf-1
Published over 50 papers in journals like Cell, Nat Cell Biol, J Clin Invest

Work Experience

2008.07~2010.12: Postdoctoral Fellow, Sun Yat-sen University
2011.01~2015.12: Associate Professor, Sun Yat-sen University
2016.01~Present: Professor, Sun Yat-sen University

Awards

2010: China's Top Ten Scientific and Technological Progress in Higher Education
2016: China's Top Ten Advances in Life Sciences
National Natural Science Award Second Prize
Guangdong Provincial Natural Science Award First Prize

Areas of Focus	Molecular Immunology Comparative Immunology
Publications	Elevated WTAP promotes hyperinflammation by increasing m6A modification in inflammatory disease models., Ge Y, Chen R, Ling T, Liu B, Huang J, Cheng Y, Lin Y, Chen H, Xie X, Xia G, Luo G, Yuan S, Xu A, 2024 Downregulation of CPSF6 leads to global mRNA 3' UTR shortening and enhanced antiviral immune responses., Ge Y, Huang J, Chen R, Fu Y, Ling T, Ou X, Rong X, Cheng Y, Lin Y, Zhou F, Lu C, Yuan S, Xu A, 2024 Characterization of GSDME in amphioxus provides insights into the functional evolution of GSDM-mediated pyroptosis., Wang X, Wei X, Lu Y, Wang Q, Fu R, Wang Y, Wang Q, Wang X, Chen S, Xu A, Yuan S, 2023 New insights into the lineage-specific expansion and functional diversification of lamprey AID/APOBEC family., Chen Y, Luo L, Deng L, Tian X, Chen S, Xu A, Yuan S, 2022 Degradation of WTAP blocks antiviral responses by reducing the m6 A levels of IRF3 and IFNAR1 mRNA., Ge Y, Ling T, Wang Y, Jia X, Xie X, Chen R, Chen S, Yuan S, Xu A, 2021 Functional regulation of an ancestral RAG transposon ProtoRAG by a trans-acting factor YY1 in lancelet., Liu S, Yuan S, Gao X, Tao X, Yu W, Li X, Chen S, Xu A, 2020 Functional requirement of terminal inverted repeats for efficient ProtoRAG activity reveals the early evolution of V(D)J recombination., Tao X, Yuan S, Chen F, Gao X, Wang X, Yu W, Liu S, Huang Z, Chen S, Xu A, 2020 Mitochondria-localized ZNFX1 functions as a dsRNA sensor to initiate antiviral responses via MAVS., Wang Y, Yuan S, Jia X, Ge Y, Ling T, Nie M, Lan X, Chen S, Xu A, 2019 DDX23, an evolutionary conserved dsRNA sensor, participates in innate antiviral responses by pairing with TRIF or MAVS., Ruan J, Cao Y, Ling T, Li P, Wu S, Peng D, Wang Y, Jia X, Chen S, Xu A, Yuan S, 2019 The role of alternative polyadenylation in the antiviral innate immune response., Jia X, Yuan S, Wang Y, Fu Y, Ge Y, Ge Y, Lan X, Feng Y, Qiu F, Li P, Chen S, Xu A, 2017 Discovery of an Active RAG Transposon Illuminates the Origins of V(D)J Recombination., Huang S, Tao X, Yuan S, Zhang Y, Li P, Beilinson HA, Zhang Y, Yu W, Pontarotti P, Escriva H, Le Petillon Y, Liu X, Chen S, Schatz DG, Xu A, 2016 Emergence of the A20/ABIN-mediated inhibition of NF-κB signaling via modifying the ubiquitinated proteins in a basal chordate., Yuan S, Dong X, Tao X, Xu L, Ruan J, Peng J, Xu A, 2014

Areas of Focus

Molecular Immunology
Comparative Immunology

Publications

Elevated WTAP promotes hyperinflammation by increasing m6A modification in inflammatory disease models., Ge Y, Chen R, Ling T, Liu B, Huang J, Cheng Y, Lin Y, Chen H, Xie X, Xia G, Luo G, Yuan S, Xu A, 2024
Downregulation of CPSF6 leads to global mRNA 3' UTR shortening and enhanced antiviral immune responses., Ge Y, Huang J, Chen R, Fu Y, Ling T, Ou X, Rong X, Cheng Y, Lin Y, Zhou F, Lu C, Yuan S, Xu A, 2024
Characterization of GSDME in amphioxus provides insights into the functional evolution of GSDM-mediated pyroptosis., Wang X, Wei X, Lu Y, Wang Q, Fu R, Wang Y, Wang Q, Wang X, Chen S, Xu A, Yuan S, 2023
New insights into the lineage-specific expansion and functional diversification of lamprey AID/APOBEC family., Chen Y, Luo L, Deng L, Tian X, Chen S, Xu A, Yuan S, 2022
Degradation of WTAP blocks antiviral responses by reducing the m6 A levels of IRF3 and IFNAR1 mRNA., Ge Y, Ling T, Wang Y, Jia X, Xie X, Chen R, Chen S, Yuan S, Xu A, 2021
Functional regulation of an ancestral RAG transposon ProtoRAG by a trans-acting factor YY1 in lancelet., Liu S, Yuan S, Gao X, Tao X, Yu W, Li X, Chen S, Xu A, 2020
Functional requirement of terminal inverted repeats for efficient ProtoRAG activity reveals the early evolution of V(D)J recombination., Tao X, Yuan S, Chen F, Gao X, Wang X, Yu W, Liu S, Huang Z, Chen S, Xu A, 2020
Mitochondria-localized ZNFX1 functions as a dsRNA sensor to initiate antiviral responses via MAVS., Wang Y, Yuan S, Jia X, Ge Y, Ling T, Nie M, Lan X, Chen S, Xu A, 2019
DDX23, an evolutionary conserved dsRNA sensor, participates in innate antiviral responses by pairing with TRIF or MAVS., Ruan J, Cao Y, Ling T, Li P, Wu S, Peng D, Wang Y, Jia X, Chen S, Xu A, Yuan S, 2019
The role of alternative polyadenylation in the antiviral innate immune response., Jia X, Yuan S, Wang Y, Fu Y, Ge Y, Ge Y, Lan X, Feng Y, Qiu F, Li P, Chen S, Xu A, 2017
Discovery of an Active RAG Transposon Illuminates the Origins of V(D)J Recombination., Huang S, Tao X, Yuan S, Zhang Y, Li P, Beilinson HA, Zhang Y, Yu W, Pontarotti P, Escriva H, Le Petillon Y, Liu X, Chen S, Schatz DG, Xu A, 2016
Emergence of the A20/ABIN-mediated inhibition of NF-κB signaling via modifying the ubiquitinated proteins in a basal chordate., Yuan S, Dong X, Tao X, Xu L, Ruan J, Peng J, Xu A, 2014

Immunology Molecular Comparative Receptors Antibodies Transcription Gene Evolution Pathogen Immune

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