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Shaochun Yuan
Life Science
Sun Yat-Sen University
Guangdong
Language: Chinese, English
Immunology
Molecular
Comparative
Receptors
Antibodies
Transcription
Gene
Evolution
Pathogen
Immune
Areas of Focus
- Molecular Immunology
- Comparative Immunology
Work Experience
- 2008.07~2010.12: Postdoctoral Fellow, Sun Yat-sen University
- 2011.01~2015.12: Associate Professor, Sun Yat-sen University
- 2016.01~Present: Professor, Sun Yat-sen University
Academic Background & Achievements
- 1999.09~2003.07: Bachelor of Science, Sun Yat-sen University
- 2003.09~2008.06: Doctor of Science, Sun Yat-sen University
- 2007.10~2008.04: Visiting Scholar, Scripps Institution of Oceanography, University of California, San Diego
- Discovered highly conserved nucleic acid recognition receptors such as ZNFX1, DDX23, Apaf-1
- Published over 50 papers in journals like Cell, Nat Cell Biol, J Clin Invest
Publications
- Elevated WTAP promotes hyperinflammation by increasing m6A modification in inflammatory disease models., Ge Y, Chen R, Ling T, Liu B, Huang J, Cheng Y, Lin Y, Chen H, Xie X, Xia G, Luo G, Yuan S, Xu A, 2024
- Downregulation of CPSF6 leads to global mRNA 3' UTR shortening and enhanced antiviral immune responses., Ge Y, Huang J, Chen R, Fu Y, Ling T, Ou X, Rong X, Cheng Y, Lin Y, Zhou F, Lu C, Yuan S, Xu A, 2024
- Characterization of GSDME in amphioxus provides insights into the functional evolution of GSDM-mediated pyroptosis., Wang X, Wei X, Lu Y, Wang Q, Fu R, Wang Y, Wang Q, Wang X, Chen S, Xu A, Yuan S, 2023
- New insights into the lineage-specific expansion and functional diversification of lamprey AID/APOBEC family., Chen Y, Luo L, Deng L, Tian X, Chen S, Xu A, Yuan S, 2022
- Degradation of WTAP blocks antiviral responses by reducing the m6 A levels of IRF3 and IFNAR1 mRNA., Ge Y, Ling T, Wang Y, Jia X, Xie X, Chen R, Chen S, Yuan S, Xu A, 2021
- Functional regulation of an ancestral RAG transposon ProtoRAG by a trans-acting factor YY1 in lancelet., Liu S, Yuan S, Gao X, Tao X, Yu W, Li X, Chen S, Xu A, 2020
- Functional requirement of terminal inverted repeats for efficient ProtoRAG activity reveals the early evolution of V(D)J recombination., Tao X, Yuan S, Chen F, Gao X, Wang X, Yu W, Liu S, Huang Z, Chen S, Xu A, 2020
- Mitochondria-localized ZNFX1 functions as a dsRNA sensor to initiate antiviral responses via MAVS., Wang Y, Yuan S, Jia X, Ge Y, Ling T, Nie M, Lan X, Chen S, Xu A, 2019
- DDX23, an evolutionary conserved dsRNA sensor, participates in innate antiviral responses by pairing with TRIF or MAVS., Ruan J, Cao Y, Ling T, Li P, Wu S, Peng D, Wang Y, Jia X, Chen S, Xu A, Yuan S, 2019
- The role of alternative polyadenylation in the antiviral innate immune response., Jia X, Yuan S, Wang Y, Fu Y, Ge Y, Ge Y, Lan X, Feng Y, Qiu F, Li P, Chen S, Xu A, 2017
- Discovery of an Active RAG Transposon Illuminates the Origins of V(D)J Recombination., Huang S, Tao X, Yuan S, Zhang Y, Li P, Beilinson HA, Zhang Y, Yu W, Pontarotti P, Escriva H, Le Petillon Y, Liu X, Chen S, Schatz DG, Xu A, 2016
- Emergence of the A20/ABIN-mediated inhibition of NF-κB signaling via modifying the ubiquitinated proteins in a basal chordate., Yuan S, Dong X, Tao X, Xu L, Ruan J, Peng J, Xu A, 2014
Awards
- 2010: China's Top Ten Scientific and Technological Progress in Higher Education
- 2016: China's Top Ten Advances in Life Sciences
- National Natural Science Award Second Prize
- Guangdong Provincial Natural Science Award First Prize
