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元少春
Life Science
中山大学
广东
Language: 中文, 英语
免疫学
分子
比较
受体
抗体
转录
基因
进化
病原体
免疫
Areas of Focus
- 分子免疫学
- 比较免疫学
Work Experience
- 2008.07~2010.12: 博士后，中山大学
- 2011.01~2015.12: 副教授，中山大学
- 2016.01~今: 教授，中山大学
Academic Background & Achievements
- 1999.09~2003.07: 理学学士，中山大学
- 2003.09~2008.06: 理学博士，中山大学
- 2007.10~2008.04: 访问学者，美国加州大学圣地亚哥分校Scripps海洋研究所
- 发现了ZNFX1，DDX23，Apaf-1等进化上高度保守的核酸识别受体
- 在Cell, Nat Cell Biol, J Clin Invest等杂志发表论文50余篇
Publications
- Elevated WTAP promotes hyperinflammation by increasing m6A modification in inflammatory disease models., Ge Y, Chen R, Ling T, Liu B, Huang J, Cheng Y, Lin Y, Chen H, Xie X, Xia G, Luo G, Yuan S, Xu A, 2024
- Downregulation of CPSF6 leads to global mRNA 3' UTR shortening and enhanced antiviral immune responses., Ge Y, Huang J, Chen R, Fu Y, Ling T, Ou X, Rong X, Cheng Y, Lin Y, Zhou F, Lu C, Yuan S, Xu A, 2024
- Characterization of GSDME in amphioxus provides insights into the functional evolution of GSDM-mediated pyroptosis., Wang X, Wei X, Lu Y, Wang Q, Fu R, Wang Y, Wang Q, Wang X, Chen S, Xu A, Yuan S, 2023
- New insights into the lineage-specific expansion and functional diversification of lamprey AID/APOBEC family., Chen Y, Luo L, Deng L, Tian X, Chen S, Xu A, Yuan S, 2022
- Degradation of WTAP blocks antiviral responses by reducing the m6 A levels of IRF3 and IFNAR1 mRNA., Ge Y, Ling T, Wang Y, Jia X, Xie X, Chen R, Chen S, Yuan S, Xu A, 2021
- Functional regulation of an ancestral RAG transposon ProtoRAG by a trans-acting factor YY1 in lancelet., Liu S, Yuan S, Gao X, Tao X, Yu W, Li X, Chen S, Xu A, 2020
- Functional requirement of terminal inverted repeats for efficient ProtoRAG activity reveals the early evolution of V(D)J recombination., Tao X, Yuan S, Chen F, Gao X, Wang X, Yu W, Liu S, Huang Z, Chen S, Xu A, 2020
- Mitochondria-localized ZNFX1 functions as a dsRNA sensor to initiate antiviral responses via MAVS., Wang Y, Yuan S, Jia X, Ge Y, Ling T, Nie M, Lan X, Chen S, Xu A, 2019
- DDX23, an evolutionary conserved dsRNA sensor, participates in innate antiviral responses by pairing with TRIF or MAVS., Ruan J, Cao Y, Ling T, Li P, Wu S, Peng D, Wang Y, Jia X, Chen S, Xu A, Yuan S, 2019
- The role of alternative polyadenylation in the antiviral innate immune response., Jia X, Yuan S, Wang Y, Fu Y, Ge Y, Ge Y, Lan X, Feng Y, Qiu F, Li P, Chen S, Xu A, 2017
- Discovery of an Active RAG Transposon Illuminates the Origins of V(D)J Recombination., Huang S, Tao X, Yuan S, Zhang Y, Li P, Beilinson HA, Zhang Y, Yu W, Pontarotti P, Escriva H, Le Petillon Y, Liu X, Chen S, Schatz DG, Xu A, 2016
- Emergence of the A20/ABIN-mediated inhibition of NF-κB signaling via modifying the ubiquitinated proteins in a basal chordate., Yuan S, Dong X, Tao X, Xu L, Ruan J, Peng J, Xu A, 2014
Awards
- 2010: 中国高等学校十大科技进展
- 2016: 中国生命科学领域十大进展
- 国家自然科学奖二等奖
- 广东省自然科学奖一等奖
