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Yinhua Zhu
Nutrition and health
China Agricultural University
Beijing
Language: Chinese, English
Chemical Biology
Protein Targets
Natural Products
Mechanisms
Anti-Aging
High-Activity
Agents
Development
Analysis
Research
Areas of Focus
- Chemical biology analysis of protein targets and mechanisms of natural products
- Development of high-activity anti-aging agents
Work Experience
- 2023.6-present - China Agricultural University - Associate Professor
- 2021.9-2023.5 - China Academy of Chinese Medical Sciences - Assistant Researcher
- 2017.9-2021.8 - Peking University - Postdoctoral Research
Academic Background & Achievements
- 2010.9-2017.7 PhD: China Agricultural University
- 2006.9-2010.7 Bachelor's: Huazhong Agricultural University
Publications
- Photoaffinity Labeling Coupled with Proteomics Identify PDI-ADAM17 Module is Targeted by (−)-Vinigrol to Induce TNFR1 Shedding and Ameliorate Rheumatoid Arthritis in Mice, Zhu Y, Wang L, Li J, Zhao Y, Yu X, Deng X, Liu J, Yang F, Zhang Y, Yu J, Lai L, Wang C, Li Z, Wang L and Luo T, 2024
- Microplastics exposure causes the senescence of human lung epithelial cells and mouse lungs by inducing ROS signaling, Jin W, Zhang W, Tang H, Wang P, Zhang Y, Liu S, Qiu J, Chen H, Wang L, Wang R, Sun Y, Liu P, Tang H and Zhu Y, 2024
- Gambogic acid suppresses the pentose phosphate pathway by covalently inhibiting 6PGD protein in cancer cells, Zhu Y, Zhang Y, Zhang Q, Ma A, Zhang Y, Wang C, Tang H, Gao P, Guo Q, Xia F, Tang H, Xu C, Wang J, 2022
- Oridonin acts as a novel senolytics by targeting Glutathione S-Transferases to activate ROS-p38 signaling axis in senescent cells, Zhang Y, Zhang Q, Chu Z, Chen L, Chen J, Yang Y, Tang H, Cheng G, Ma A, Zhang Y, Wang C, Gao P, Xia F, Guo Q, Shi Q, Han G, Wang J and Zhu Y, 2022
- Elimination of senescent cells by β-galactosidase-targeted prodrug attenuates inflammation and restores physical function in aged mice, Cai Y, Zhou H, Zhu Y, Sun Q, Ji Y, Xue A, Wang Y, Chen W, Yu X, Wang L, Chen H, Li C, Luo T and Deng H, 2020
- Effective treatment of SARS-CoV-2-infected rhesus macaques by attenuating inflammation, Lu S, Zhao J, Dong J, Liu H, Zhu Y, Li H, Liu L, Yang Y, Sun S, Song Y, Zhao Y, She R, Luo T, Deng H, and Peng X, 2020
- Cholesterol modulates the physiological response to nanoparticles by changing the composition of protein corona, Tang H, Zhang Y, Yang T, Wang C, Zhu Y, Qiu L, Liu J, Song Y, Zhou L, Zhang J, Wong YK, Liu Y, Xu C, Wang H, Wang J, 2023
- BAK1 plays contrasting roles in regulating abscisic acid-induced stomatal closure and abscisic acid-inhibited primary root growth in Arabidopsis, Deng J, Kong L, Zhu Y, Pei D, Chen X, Wang Y, Qi J, Song C, Yang S, Gong Z, 2022
- Tonsillar Microbiome-Derived Lantibiotics Induce Structural Changes of IL-6 and IL-21 Receptors and Modulate Host Immunity, Li J, Jin J, Li S, Zhong Y, Jin Y, Zhang X, Xia B, Zhu Y, Guo R, Sun X, Guo J, Hu F, Xiao W, Huang F, Ye H, Li R, Zhou Y, Xiang X, Yao H, Yan Q, Su L, Wu L, Luo T, Liu Y, Guo X, Qin J, Qi H, He J, Wang J, Li Z, 2022
- Surface chemistry of graphene tailoring the activity of digestive enzymes by modulating interfacial molecular interactions, Tang H, Yang T, Chen L, Zhang Y, Zhu Y, Wang C, Liu D, Guo Q, Cheng G, Xia F, Zhong T and Wang J, 2023
- How eluents define proteomic fingerprinting of protein corona on nanoparticles, Qiu L, Zhang Y, Wei G, Wang C, Zhu Y, Yang T, Chu Z, Gao P, Cheng G, Ma A, Kwan Wong Y, Zhang J, Xu C, Wang J, Tang H, 2023
- Chemoproteomics reveals Sofalcone inhibits the inflammatory response of Caco-2 cells by covalently targeting HMGB1, Yang T, Liu D, Li Y, Zhang Y, Zhu Y, Zhang J, Wang C, Zhang S, Wong YK, Luo P, Guo Q, Xia F, Zhong T, Tang H, Wang J, 2023
- Chemical proteomic profiling with photoaffinity labeling strategy identifies antimalarial targets of artemisinin, Gao P, Chen J, Sun P, Wang J, Tang H, Xia F, Gu L, Zhang H, Wang C, Wong Y, Zhu Y, Xu C, Wang J, 2023
- Glycyrrhizic Acid Mitigates Tripterygium-Glycoside-Tablet-Induced Acute Liver Injury via PKM2 Regulated Oxidative Stress, Wang Q, Huang Y, Li Y, Zhang L, Tang H, Zhang J, Cheng G, Zhao M, Lu T, Zhang Q, Luo P, Zhu Y, Xia F, Zhang Y, Liu D, Wang C, Li H, Qiu C, Wang J, Guo Q, 2022
Awards
- Sanofi-Cell Research Outstanding Paper Award (2020): For the paper on β-galactosidase-targeted prodrug
