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Yang Chen
Basic Medical Sciences
Peking Union Medical College
Beijing
Language: Chinese, English
Spatiotemporal Omics
Bioinformatics
Genomic Structure
Disease Function
Individualized Treatment
Genomics
Bioinformatics Methods
Diagnosis Strategies
Treatment Strategies
Disease Genomics
Areas of Focus
- Research on spatiotemporal omics technology and bioinformatics methods
- Study of genomic spatial structure and function in diseases
- Research on new strategies for individualized diagnosis and treatment of diseases
Work Experience
- 2008.09-2011.07 - Tsinghua University, Department of Automation, Assistant Researcher
- 2011.08-2020.12 - Tsinghua University, National Research Center for Information, Assistant Researcher, Associate Researcher
- 2020.12-present - Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, Researcher, Doctoral Supervisor
Academic Background & Achievements
- 1999.09-2002.06 Bachelor: Sun Yat-sen University, Pharmacy
- 2002.09-2005.06 Master: Peking Union Medical College, Immunology
- 2005.09-2008.06 PhD: Peking Union Medical College, Biochemistry and Molecular Biology
- Published over 50 papers in journals like Nature Methods, Nature Communications, Genome Biology
- Received 3 Chinese invention patents and 2 software copyrights
- Research achievements selected as top ten advances in Chinese bioinformatics in 2018 and 2021
Publications
- Multi-omics Metabolic and Epigenetics Regulatory Network in Cancer: A Systems Biology Perspective, Xuezhu Wang, Yucheng Dong, Yongchangzheng, Yang Chen, 2021
- SEAM is a spatial single nuclear metabolomics method for dissecting tissue microenvironment, Zhiyuan Yuan, Qiming Zhou, Lesi Cai, Lin Pan, Weiliang Sun, Shiwei Qumu, Si Yu, Jiaxin Feng, Hansen Zhao, Yongchang Zheng, Minglei Shi, Shao Li, Yang Chen, Xinrong Zhang, Michael Q. Zhang, 2021
- Quantifying the phase separation property of chromatin-associated proteins under physiological conditions using an anti-1,6-hexanediol index, Minglei Shi, Kaiqiang You, Taoyu Chen, Chao Hou, Zhengyu Liang, Mingwei Liu, Jifeng Wang, Taotao Wei, Jun Qin, Yang Chen, Michael Q Zhang, Tingting Li, 2021
- Spatial density of open chromatin: an effective metric for the functional characterization of topologically associated domains, Shuai Jiang, Hao Li, Hao Hong, Guifang Du, Xin Huang, Yu Sun, Junting Wang, Huan Tao, Kang Xu, Cheng Li, Yang Chen, Hebing Chen, Xiaochen Bo, 2020
- PhaSepDB: a database of liquid–liquid phase separation related proteins, Kaiqiang You, Qi Huang, Chunyu Yu, Boyan Shen, Cristoffer Sevilla, Minglei Shi, Henning Hermjakob, Yang Chen, Tingting Li, 2020
- HiCDB: a sensitive and robust method for detecting contact domain boundaries, Fengling Chen, Guipeng Li, Michael Q Zhang, Yang Chen, 2018
- FIND: difFerential chromatin INteractions Detection using a spatial Poisson process, Mohamed Nadhir Djekidel, Yang Chen, Michael Q. Zhang, 2018
- Alterations of specific chromatin conformation affect ATRA-induced leukemia cell differentiation, Yanjian Li, Yi He, Zhengyu Liang, Yang Wang, Fengling Chen, Mohamed Nadhir Djekidel, Guipeng Li, Xu Zhang, Shuqin Xiang, Zejun Wang, Juntao Gao, Michael Q. Zhang, Yang Chen, 2018
- BL-Hi-C is an efficient and sensitive approach for capturing structural and regulatory chromatin interactions, Zhengyu Liang, Guipeng Li, Zejun Wang, Mohamed Nadhir Djekidel, Yanjian Li, Minping Qian, Michael Q. Zhang, Yang Chen, 2017
- Engineering EMT using 3D micro-scaffold to promote hepatic functions for drug hepatotoxicity evaluation, Jingyu Wang, Fengling Chen, Longwei Liu, Chunxiao Qi, Bingjie Wang, Xiaojun Yan, Chenyu Huang, Wei Hou, Michael Q. Zhang, Yang Chen, Yanan Du, 2016
- 3CPET: finding co-factor complexes from ChIA-PET data using a hierarchical Dirichlet process, Mohamed Nadhir Djekidel, Zhengyu Liang, Qi Wang, Zhirui Hu, Guipeng Li, Yang Chen, Michael Q. Zhang, 2015
Awards
- 2018: Research achievements selected as top ten advances in Chinese bioinformatics
- 2021: Research achievements selected as top ten advances in Chinese bioinformatics
