Professor | Cai Gang | Asia Growth Partners

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Name	Cai Gang
Contact Information	gcai@ustc.edu.cn
Language ability	English, Chinese
Province	Anhui

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Name

Cai Gang

Contact Information

gcai@ustc.edu.cn

Language ability

English, Chinese

Province

Anhui

University/Lab Affiliation and Title	University of Science and Technology of China
Faculty	Life Sciences
Academic Background & Achievements	2001 - Bachelor's degree: Anhui University 2006 - Doctorate: Shanghai Institute of Life Sciences, Chinese Academy of Sciences Developed methods for high-efficiency preparation of protein complexes Overcame key bottlenecks in cryo-electron microscopy for high-resolution structure analysis
Work Experience	2006-2010 - Postdoctoral training: Scripps Research Institute, USA
Awards	2019 - National High-Level Talent Special Support Plan for Science and Technology Innovation Leading Talent 2018 - 12th WuXi AppTec Life Chemistry Research Award 2017 - Outstanding Research Principal Award, University of Science and Technology of China 2012 - Excellent Young Scientists Fund, National Natural Science Foundation 2011 - New Century Excellent Talents Support Plan, Ministry of Education

University/Lab Affiliation and Title

University of Science and Technology of China

Faculty

Life Sciences

Academic Background & Achievements

2001 - Bachelor's degree: Anhui University
2006 - Doctorate: Shanghai Institute of Life Sciences, Chinese Academy of Sciences
Developed methods for high-efficiency preparation of protein complexes
Overcame key bottlenecks in cryo-electron microscopy for high-resolution structure analysis

Work Experience

2006-2010 - Postdoctoral training: Scripps Research Institute, USA

Awards

2019 - National High-Level Talent Special Support Plan for Science and Technology Innovation Leading Talent
2018 - 12th WuXi AppTec Life Chemistry Research Award
2017 - Outstanding Research Principal Award, University of Science and Technology of China
2012 - Excellent Young Scientists Fund, National Natural Science Foundation
2011 - New Century Excellent Talents Support Plan, Ministry of Education

Areas of Focus	Molecular mechanisms of genome stability and meiotic recombination regulation using cryo-electron microscopy
Publications	3.9 Å structure of the yeast Mec1-Ddc2 complex, a homolog of human ATR-ATRIP, Wang, X., Ran, T., Zhang, X., Xin, J., Zhang, Z., Wu, T., Wang, W. and Cai, G., 2017 Structural insight into mechanisms of ATM activation, Xin, J., Xu, Z., Wang, X., Tian Y., Zhang, Z. and Cai, G., 2019 Architecture of the Saccharomyces cerevisiae NuA4/TIP60 complex, Wang, X., Ahmad, S., Zhang, Z., Côté, J., Cai, G., 2018 Architecture of SWI/SNF chromatin remodeling complex, Zhang, Z., Wang, X., Xin, J., Ding, Z., Liu, S., Fang, Q., Yang, N., Xu, R., Cai, G., 2018 Structure and Functional Interactions of INO80 Actin/Arp Module, Zhang, X., Wang, X.,* Zhang, Z. and Cai, G., 2018 Structure of the intact ATM/Tel1 kinase, Wang, X., Chu, H., Lv, M., Zhang, Z., Qiu, S., Liu, H., Shen, X., Wang, W., Cai, G., 2016 Redefining the Modular Organization of the Core Mediator Complex, Wang, X., Sun, Q., Ding, Z., Ji, J., Wang, J., Kong, X., Yang J.H., and Cai, G., 2014 AI-2 quorum sensing negatively regulates rbf expression and biofilm formation in Staphylococcus aureus, Ma, R., Qiu, S., Jiang, Q., Sun, H., Xue, H., Cai, G.,* and Sun, B., 2017 Crystal and EM structures of human phosphoribosyl pyrophosphate synthase I (PRS1) provide novel insights into the disease-associated mutations, Chen, P., Liu, Z., Wang, X., Sun, Q., Li, J., Wang, M., Niu, L., Cai, G., Teng, M.,* Li, X., 2015 Structural flexibility and functional interaction of mediator Cdk8 module, Wang, X., Wang, J., Ding, Z., Ji, J., Sun, Q., and Cai, G., 2013

Areas of Focus

Molecular mechanisms of genome stability and meiotic recombination regulation using cryo-electron microscopy

Publications

3.9 Å structure of the yeast Mec1-Ddc2 complex, a homolog of human ATR-ATRIP, Wang, X., Ran, T., Zhang, X., Xin, J., Zhang, Z., Wu, T., Wang, W. and Cai, G*., 2017
Structural insight into mechanisms of ATM activation, Xin, J., Xu, Z., Wang, X., Tian Y., Zhang, Z. and Cai, G*., 2019
Architecture of the Saccharomyces cerevisiae NuA4/TIP60 complex, Wang, X*., Ahmad, S., Zhang, Z., Côté, J., Cai, G*., 2018
Architecture of SWI/SNF chromatin remodeling complex, Zhang, Z., Wang, X*., Xin, J., Ding, Z., Liu, S., Fang, Q., Yang, N., Xu, R., Cai, G*., 2018
Structure and Functional Interactions of INO80 Actin/Arp Module, Zhang, X., Wang, X.,* Zhang, Z. and Cai, G*., 2018
Structure of the intact ATM/Tel1 kinase, Wang, X., Chu, H., Lv, M., Zhang, Z., Qiu, S., Liu, H., Shen, X., Wang, W*., Cai, G*., 2016
Redefining the Modular Organization of the Core Mediator Complex, Wang, X., Sun, Q., Ding, Z., Ji, J., Wang, J., Kong, X., Yang J.H., and Cai, G.*, 2014
AI-2 quorum sensing negatively regulates rbf expression and biofilm formation in Staphylococcus aureus, Ma, R., Qiu, S., Jiang, Q., Sun, H., Xue, H., Cai, G.,* and Sun, B.*, 2017
Crystal and EM structures of human phosphoribosyl pyrophosphate synthase I (PRS1) provide novel insights into the disease-associated mutations, Chen, P., Liu, Z., Wang, X., Sun, Q., Li, J., Wang, M., Niu, L., Cai, G.,* Teng, M.,* Li, X.*, 2015
Structural flexibility and functional interaction of mediator Cdk8 module, Wang, X., Wang, J., Ding, Z., Ji, J., Sun, Q., and Cai, G.*, 2013

Genome Stability Meiotic Recombination Cryo-Electron Microscopy Molecular Mechanisms Protein Complexes High-Resolution Structure Dynamic Interactions Disease Research Drug Development Tumor Therapy

Xiaoling Yu - Southern University of Science and Technology

Fei Sun - University of Chinese Academy of Sciences

Yi Xiao Zhang - University of Chinese Academy of Sciences

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