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Cai Gang
Life Science
University of Science and Technology of China
Anhui
Language: English, Chinese
Genome Stability
Meiotic Recombination
Cryo-Electron Microscopy
Molecular Mechanisms
Protein Complexes
High-Resolution Structure
Dynamic Interactions
Disease Research
Drug Development
Tumor Therapy
Areas of Focus
- Molecular mechanisms of genome stability and meiotic recombination regulation using cryo-electron microscopy
Work Experience
- 2006-2010 - Postdoctoral training: Scripps Research Institute, USA
Academic Background & Achievements
- 2001 - Bachelor's degree: Anhui University
- 2006 - Doctorate: Shanghai Institute of Life Sciences, Chinese Academy of Sciences
- Developed methods for high-efficiency preparation of protein complexes
- Overcame key bottlenecks in cryo-electron microscopy for high-resolution structure analysis
Publications
- 3.9 Å structure of the yeast Mec1-Ddc2 complex, a homolog of human ATR-ATRIP, Wang, X., Ran, T., Zhang, X., Xin, J., Zhang, Z., Wu, T., Wang, W. and Cai, G*., 2017
- Structural insight into mechanisms of ATM activation, Xin, J., Xu, Z., Wang, X., Tian Y., Zhang, Z. and Cai, G*., 2019
- Architecture of the Saccharomyces cerevisiae NuA4/TIP60 complex, Wang, X*., Ahmad, S., Zhang, Z., Côté, J., Cai, G*., 2018
- Architecture of SWI/SNF chromatin remodeling complex, Zhang, Z., Wang, X*., Xin, J., Ding, Z., Liu, S., Fang, Q., Yang, N., Xu, R., Cai, G*., 2018
- Structure and Functional Interactions of INO80 Actin/Arp Module, Zhang, X., Wang, X.,* Zhang, Z. and Cai, G*., 2018
- Structure of the intact ATM/Tel1 kinase, Wang, X., Chu, H., Lv, M., Zhang, Z., Qiu, S., Liu, H., Shen, X., Wang, W*., Cai, G*., 2016
- Redefining the Modular Organization of the Core Mediator Complex, Wang, X., Sun, Q., Ding, Z., Ji, J., Wang, J., Kong, X., Yang J.H., and Cai, G.*, 2014
- AI-2 quorum sensing negatively regulates rbf expression and biofilm formation in Staphylococcus aureus, Ma, R., Qiu, S., Jiang, Q., Sun, H., Xue, H., Cai, G.,* and Sun, B.*, 2017
- Crystal and EM structures of human phosphoribosyl pyrophosphate synthase I (PRS1) provide novel insights into the disease-associated mutations, Chen, P., Liu, Z., Wang, X., Sun, Q., Li, J., Wang, M., Niu, L., Cai, G.,* Teng, M.,* Li, X.*, 2015
- Structural flexibility and functional interaction of mediator Cdk8 module, Wang, X., Wang, J., Ding, Z., Ji, J., Sun, Q., and Cai, G.*, 2013
Awards
- 2019 - National High-Level Talent Special Support Plan for Science and Technology Innovation Leading Talent
- 2018 - 12th WuXi AppTec Life Chemistry Research Award
- 2017 - Outstanding Research Principal Award, University of Science and Technology of China
- 2012 - Excellent Young Scientists Fund, National Natural Science Foundation
- 2011 - New Century Excellent Talents Support Plan, Ministry of Education
