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Daxing Gao
Basic Medical Sciences
University of Science and Technology of China
Anhui
Language: English, Chinese
Antiviral
Innate Immunity
Mechanisms
Auto-Inflammation
Immune Signaling
Tumor
Treatment
Strategies
Novel
Development
Areas of Focus
- Antiviral innate immunity mechanisms
- Role of innate immune signaling in auto-inflammation
- Development of novel tumor treatment strategies
Work Experience
- 2016-2019 Postdoctoral Research: Rockefeller University
- 2019-present Professor: University of Science and Technology of China
Academic Background & Achievements
- 2006-2010 Bachelor: University of Science and Technology of China
- 2010-2015 PhD in Immunology: University of Texas Southwestern Medical Center
- 2018 Revson Fellowship
Publications
- cGAS-activated endothelial cell-T cell cross-talk initiates tertiary lymphoid structure formation, R. Zhao, J. Zhang, J. Ma, Y. Qu, Z. Yang, Z. Yin, F. Li, Z. Dong, Q. Sun, S. Zhu, Z. J. Chen, D. Gao, 2024
- Human DBR1 deficiency impairs stress granule-dependent PKR antiviral immunity, Shuo Ru, Sisi Tang, Hui Xu, Jiahao Yin, Yan Guo, Liuping Song, Zhenyu Jin, Danyel Lee, Yi-Hao Chan, Xingyao Chen, Luke Buerer, William Fairbrother, Weidong Jia, Jean-Laurent Casanova, Shen-Ying Zhang, Daxing Gao, 2024
- SARS-CoV-2 brainstem encephalitis in human inherited DBR1 deficiency, Y.-H. Chan, V. Lundberg, J. Le Pen, J. Yuan, D. Lee, F. Pinci, S. Volpi, K. Nakajima, V. Bondet, S. Åkesson, N. V. Khobrekar, A. Bodansky, L. Du, T. Melander, A.-A. Mariaggi, Y. Seeleuthner, T. S. Saleh, D. Chakravarty, P. Marits, K. Dobbs, S. Vonlanthen, V. Hennings, K. Thörn, D. Rinchai, L. Bizien, M. Chaldebas, A. Sobh, T. Özçelik, S. Keles, S. A. AlKhater, C. Prando, I. Meyts, COVID Human Genetic Effort, M. R. Wilson, J. Rosain, E. Jouanguy, M. Aubart, L. Abel, T. H. Mogensen, Q. Pan-Hammarström, D. Gao, D. Duffy, A. Cobat, S. Berg, L. D. Notarangelo, O. Harschnitz, C. M. Rice, L. Studer, J.-L. Casanova, O. Ekwall, S.-Y. Zhang, 2024
- TLR3 controls constitutive IFN-β antiviral immunity in human fibroblasts and cortical neurons, D. Gao, M. J. Ciancanelli, P. Zhang, O. Harschnitz, V. Bondet, M. Hasek, J. Chen, X. Mu, Y. Itan, A. Cobat, V. Sancho-Shimizu, B. Bigio, L. Lorenzo, G. Ciceri, J. McAlpine, E. Anguiano, E. Jouanguy, D. Chaussabel, I. Meyts, M. S. Diamond, L. Abel, S. Hur, G. A. Smith, L. Notarangelo, D. Duffy, L. Studer, J.-L. Casanova, S.-Y. Zhang, 2021
- Human SNORA31 variations impair cortical neuron-intrinsic immunity to HSV-1 and underlie herpes simplex encephalitis, F. G. Lafaille, O. Harschnitz, Y. S. Lee, P. Zhang, M. L. Hasek, G. Kerner, Y. Itan, O. Ewaleifoh, F. Rapaport, T. M. Carlile, M. E. Carter-Timofte, D. Paquet, K. Dobbs, B. Zimmer, D. Gao, M. F. Rojas-Duran, D. Kwart, V. Rattina, M. J. Ciancanelli, J. L. McAlpine, L. Lorenzo, S. Boucherit, F. Rozenberg, R. Halwani, B. Henry, N. Amenzoui, Z. Alsum, L. Marques, J. A. Church, S. Al-Muhsen, M. Tardieu, A. A. Bousfiha, S. R. Paludan, T. H. Mogensen, L. Quintana-Murci, M. Tessier-Lavigne, G. A. Smith, L. D. Notarangelo, L. Studer, W. Gilbert, L. Abel, J. L. Casanova, S. Y. Zhang, 2019
- Activation of cyclic GMP-AMP synthase by self-DNA causes autoimmune diseases, D. Gao, T. Li, X.-D. Li, X. Chen, Q.-Z. Li, M. Wight-Carter, Z. J. Chen, 2015
- Cyclic GMP-AMP synthase is an innate immune sensor of HIV and other retroviruses, D. Gao, J. Wu, Y. T. Wu, F. Du, C. Aroh, N. Yan, L. Sun, Z. J. Chen, 2013
- Pivotal roles of cGAS-cGAMP signaling in antiviral defense and immune adjuvant effects, X. D. Li, J. Wu, D. Gao, H. Wang, L. Sun, Z. J. Chen, 2013
- Engineered extracellular vesicles enable high-efficient delivery of intracellular therapeutic proteins, D. Ma, A. Xie, J. Lv, X. Min, X. Zhang, Q. Zhou, D. Gao, E. Wang, L. Gao, L. Cheng, S. Liu, 2024
Awards
- 2014 Chinese Government Award for Outstanding Self-financed Students Abroad
- 2014 American Association of Immunologists Young Investigator Award
- 2015 Streilein Chair Freedom Award
