Professor | 高大兴 | 数字化转型顾问

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Name	高大兴
Contact Information	daxing@ustc.edu.cn
Language ability	英语, 中文
Province	安徽

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Name

高大兴

Contact Information

daxing@ustc.edu.cn

Language ability

英语, 中文

Province

安徽

University/Lab Affiliation and Title	中国科学技术大学
Faculty	Basic Medical Sciences
Academic Background & Achievements	2006-2010 学士学位：中国科学技术大学 2010-2015 免疫学博士学位：美国德克萨斯大学西南医学中心 2018 Revson基金资助
Work Experience	2016-2019 博士后研究：美国洛克菲勒大学 2019年至今教授：中国科学技术大学
Awards	2014年中国国家优秀自费留学生奖学金 2014年美国免疫协会青年研究员奖 2015年Streilein主席自由奖

University/Lab Affiliation and Title

中国科学技术大学

Faculty

Basic Medical Sciences

Academic Background & Achievements

2006-2010 学士学位：中国科学技术大学
2010-2015 免疫学博士学位：美国德克萨斯大学西南医学中心
2018 Revson基金资助

Work Experience

2016-2019 博士后研究：美国洛克菲勒大学
2019年至今教授：中国科学技术大学

Awards

2014年中国国家优秀自费留学生奖学金
2014年美国免疫协会青年研究员奖
2015年Streilein主席自由奖

Areas of Focus	抗病毒天然免疫机制天然免疫信号通路在自身炎症中的作用新型肿瘤治疗策略的开发
Publications	cGAS-activated endothelial cell-T cell cross-talk initiates tertiary lymphoid structure formation, R. Zhao, J. Zhang, J. Ma, Y. Qu, Z. Yang, Z. Yin, F. Li, Z. Dong, Q. Sun, S. Zhu, Z. J. Chen, D. Gao, 2024 Human DBR1 deficiency impairs stress granule-dependent PKR antiviral immunity, Shuo Ru, Sisi Tang, Hui Xu, Jiahao Yin, Yan Guo, Liuping Song, Zhenyu Jin, Danyel Lee, Yi-Hao Chan, Xingyao Chen, Luke Buerer, William Fairbrother, Weidong Jia, Jean-Laurent Casanova, Shen-Ying Zhang, Daxing Gao, 2024 SARS-CoV-2 brainstem encephalitis in human inherited DBR1 deficiency, Y.-H. Chan, V. Lundberg, J. Le Pen, J. Yuan, D. Lee, F. Pinci, S. Volpi, K. Nakajima, V. Bondet, S. Åkesson, N. V. Khobrekar, A. Bodansky, L. Du, T. Melander, A.-A. Mariaggi, Y. Seeleuthner, T. S. Saleh, D. Chakravarty, P. Marits, K. Dobbs, S. Vonlanthen, V. Hennings, K. Thörn, D. Rinchai, L. Bizien, M. Chaldebas, A. Sobh, T. Özçelik, S. Keles, S. A. AlKhater, C. Prando, I. Meyts, COVID Human Genetic Effort, M. R. Wilson, J. Rosain, E. Jouanguy, M. Aubart, L. Abel, T. H. Mogensen, Q. Pan-Hammarström, D. Gao, D. Duffy, A. Cobat, S. Berg, L. D. Notarangelo, O. Harschnitz, C. M. Rice, L. Studer, J.-L. Casanova, O. Ekwall, S.-Y. Zhang, 2024 TLR3 controls constitutive IFN-β antiviral immunity in human fibroblasts and cortical neurons, D. Gao, M. J. Ciancanelli, P. Zhang, O. Harschnitz, V. Bondet, M. Hasek, J. Chen, X. Mu, Y. Itan, A. Cobat, V. Sancho-Shimizu, B. Bigio, L. Lorenzo, G. Ciceri, J. McAlpine, E. Anguiano, E. Jouanguy, D. Chaussabel, I. Meyts, M. S. Diamond, L. Abel, S. Hur, G. A. Smith, L. Notarangelo, D. Duffy, L. Studer, J.-L. Casanova, S.-Y. Zhang, 2021 Human SNORA31 variations impair cortical neuron-intrinsic immunity to HSV-1 and underlie herpes simplex encephalitis, F. G. Lafaille, O. Harschnitz, Y. S. Lee, P. Zhang, M. L. Hasek, G. Kerner, Y. Itan, O. Ewaleifoh, F. Rapaport, T. M. Carlile, M. E. Carter-Timofte, D. Paquet, K. Dobbs, B. Zimmer, D. Gao, M. F. Rojas-Duran, D. Kwart, V. Rattina, M. J. Ciancanelli, J. L. McAlpine, L. Lorenzo, S. Boucherit, F. Rozenberg, R. Halwani, B. Henry, N. Amenzoui, Z. Alsum, L. Marques, J. A. Church, S. Al-Muhsen, M. Tardieu, A. A. Bousfiha, S. R. Paludan, T. H. Mogensen, L. Quintana-Murci, M. Tessier-Lavigne, G. A. Smith, L. D. Notarangelo, L. Studer, W. Gilbert, L. Abel, J. L. Casanova, S. Y. Zhang, 2019 Activation of cyclic GMP-AMP synthase by self-DNA causes autoimmune diseases, D. Gao, T. Li, X.-D. Li, X. Chen, Q.-Z. Li, M. Wight-Carter, Z. J. Chen, 2015 Cyclic GMP-AMP synthase is an innate immune sensor of HIV and other retroviruses, D. Gao, J. Wu, Y. T. Wu, F. Du, C. Aroh, N. Yan, L. Sun, Z. J. Chen, 2013 Pivotal roles of cGAS-cGAMP signaling in antiviral defense and immune adjuvant effects, X. D. Li, J. Wu, D. Gao, H. Wang, L. Sun, Z. J. Chen, 2013 Engineered extracellular vesicles enable high-efficient delivery of intracellular therapeutic proteins, D. Ma, A. Xie, J. Lv, X. Min, X. Zhang, Q. Zhou, D. Gao, E. Wang, L. Gao, L. Cheng, S. Liu, 2024

Areas of Focus

抗病毒天然免疫机制
天然免疫信号通路在自身炎症中的作用
新型肿瘤治疗策略的开发

Publications

cGAS-activated endothelial cell-T cell cross-talk initiates tertiary lymphoid structure formation, R. Zhao, J. Zhang, J. Ma, Y. Qu, Z. Yang, Z. Yin, F. Li, Z. Dong, Q. Sun, S. Zhu, Z. J. Chen, D. Gao, 2024
Human DBR1 deficiency impairs stress granule-dependent PKR antiviral immunity, Shuo Ru, Sisi Tang, Hui Xu, Jiahao Yin, Yan Guo, Liuping Song, Zhenyu Jin, Danyel Lee, Yi-Hao Chan, Xingyao Chen, Luke Buerer, William Fairbrother, Weidong Jia, Jean-Laurent Casanova, Shen-Ying Zhang, Daxing Gao, 2024
SARS-CoV-2 brainstem encephalitis in human inherited DBR1 deficiency, Y.-H. Chan, V. Lundberg, J. Le Pen, J. Yuan, D. Lee, F. Pinci, S. Volpi, K. Nakajima, V. Bondet, S. Åkesson, N. V. Khobrekar, A. Bodansky, L. Du, T. Melander, A.-A. Mariaggi, Y. Seeleuthner, T. S. Saleh, D. Chakravarty, P. Marits, K. Dobbs, S. Vonlanthen, V. Hennings, K. Thörn, D. Rinchai, L. Bizien, M. Chaldebas, A. Sobh, T. Özçelik, S. Keles, S. A. AlKhater, C. Prando, I. Meyts, COVID Human Genetic Effort, M. R. Wilson, J. Rosain, E. Jouanguy, M. Aubart, L. Abel, T. H. Mogensen, Q. Pan-Hammarström, D. Gao, D. Duffy, A. Cobat, S. Berg, L. D. Notarangelo, O. Harschnitz, C. M. Rice, L. Studer, J.-L. Casanova, O. Ekwall, S.-Y. Zhang, 2024
TLR3 controls constitutive IFN-β antiviral immunity in human fibroblasts and cortical neurons, D. Gao, M. J. Ciancanelli, P. Zhang, O. Harschnitz, V. Bondet, M. Hasek, J. Chen, X. Mu, Y. Itan, A. Cobat, V. Sancho-Shimizu, B. Bigio, L. Lorenzo, G. Ciceri, J. McAlpine, E. Anguiano, E. Jouanguy, D. Chaussabel, I. Meyts, M. S. Diamond, L. Abel, S. Hur, G. A. Smith, L. Notarangelo, D. Duffy, L. Studer, J.-L. Casanova, S.-Y. Zhang, 2021
Human SNORA31 variations impair cortical neuron-intrinsic immunity to HSV-1 and underlie herpes simplex encephalitis, F. G. Lafaille, O. Harschnitz, Y. S. Lee, P. Zhang, M. L. Hasek, G. Kerner, Y. Itan, O. Ewaleifoh, F. Rapaport, T. M. Carlile, M. E. Carter-Timofte, D. Paquet, K. Dobbs, B. Zimmer, D. Gao, M. F. Rojas-Duran, D. Kwart, V. Rattina, M. J. Ciancanelli, J. L. McAlpine, L. Lorenzo, S. Boucherit, F. Rozenberg, R. Halwani, B. Henry, N. Amenzoui, Z. Alsum, L. Marques, J. A. Church, S. Al-Muhsen, M. Tardieu, A. A. Bousfiha, S. R. Paludan, T. H. Mogensen, L. Quintana-Murci, M. Tessier-Lavigne, G. A. Smith, L. D. Notarangelo, L. Studer, W. Gilbert, L. Abel, J. L. Casanova, S. Y. Zhang, 2019
Activation of cyclic GMP-AMP synthase by self-DNA causes autoimmune diseases, D. Gao, T. Li, X.-D. Li, X. Chen, Q.-Z. Li, M. Wight-Carter, Z. J. Chen, 2015
Cyclic GMP-AMP synthase is an innate immune sensor of HIV and other retroviruses, D. Gao, J. Wu, Y. T. Wu, F. Du, C. Aroh, N. Yan, L. Sun, Z. J. Chen, 2013
Pivotal roles of cGAS-cGAMP signaling in antiviral defense and immune adjuvant effects, X. D. Li, J. Wu, D. Gao, H. Wang, L. Sun, Z. J. Chen, 2013
Engineered extracellular vesicles enable high-efficient delivery of intracellular therapeutic proteins, D. Ma, A. Xie, J. Lv, X. Min, X. Zhang, Q. Zhou, D. Gao, E. Wang, L. Gao, L. Cheng, S. Liu, 2024

抗病毒天然免疫机制自身炎症免疫信号肿瘤治疗策略新型开发

游富平 - 北京大学

周全 - 浙江大学

蔡华 - 广州医科大学

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