Professor | Han You | Asia Growth Partners

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Name	Han You
Contact Information	hyou@xmu.edu.cn
Language ability	English, Chinese
Province	Fujian

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Name

Han You

Contact Information

hyou@xmu.edu.cn

Language ability

English, Chinese

Province

Fujian

University/Lab Affiliation and Title	Xiamen University
Faculty	Life Sciences
Academic Background & Achievements	1999 - Bachelor's/Master's Degree in Clinical Medicine: Fourth Military Medical University 2002 - Ph.D. in Clinical Medicine: Fourth Military Medical University 2017 - Received National Outstanding Youth Science Fund
Work Experience	2000-2001 - Visiting Student - Boston University School of Medicine 2001-2003 - Visiting Scholar - Massachusetts Institute of Technology 2003-2007 - Postdoc Fellow - University of Toronto 2007-Present - Professor/Doctoral Supervisor - School of Life Sciences, Xiamen University 2011-Present - Deputy Director - State Key Laboratory of Cellular Stress Biology
Awards	2017: National Outstanding Youth Science Fund

University/Lab Affiliation and Title

Xiamen University

Faculty

Life Sciences

Academic Background & Achievements

1999 - Bachelor's/Master's Degree in Clinical Medicine: Fourth Military Medical University
2002 - Ph.D. in Clinical Medicine: Fourth Military Medical University
2017 - Received National Outstanding Youth Science Fund

Work Experience

2000-2001 - Visiting Student - Boston University School of Medicine
2001-2003 - Visiting Scholar - Massachusetts Institute of Technology
2003-2007 - Postdoc Fellow - University of Toronto
2007-Present - Professor/Doctoral Supervisor - School of Life Sciences, Xiamen University
2011-Present - Deputy Director - State Key Laboratory of Cellular Stress Biology

Awards

2017: National Outstanding Youth Science Fund

Areas of Focus	Reciprocal regulation between PI3K/AKT/FoxO pathway and epigenetic modulation mechanisms Chemoresistance and cancer metastasis Regulation of cell differentiation, apoptosis, and autophagy
Publications	A deregulated m6A writer complex axis driven by BRD4 confers an epitranscriptomic vulnerability in combined DNA repair-targeted therapy., Xiao Lu, Lichao Peng, Jiancheng Ding, Yuanpei Li, Qing Li, Mengchen Rao, Tong Shu, Xiaoniu He, Chen Liu, Jing Ye, Wen Liu, Han You., 2023 METTL3 acetylation impedes cancer metastasis via fine-tuning its nuclear and cytosolic functions., Yuanpei Li, Xiaoniu He, Xiao Lu, Zhicheng Gong, Qing Li, Lei Zhang, Ronghui Yang, Chengyi Wu, Jialiang Huang, Jiancheng Ding, Yaohui He, Wen Liu, Ceshi Chen, Bin Cao, Dawang Zhou,YuFeng Shi, Juxiang Chen, Chuangui Wang, Shengping Zhang, Jian Zhang, Jing Ye, Han You., 2022 OTUD7B Deubiquitinates LSD1 to Govern Its Binding Partner Specificity, Homeostasis and Breast Cancer Metastasis., Gong, Z., Li AC., Ding JC., Li, Q., Zhang L., Li YP., Meng Z., Chen F., Huang JL., Zhou DW., Hu RG., Ye, J., Liu W. and You, H., 2021 Geminin facilitates FoxO3 deacetylation to promote breast cancer cell metastasis., Zhang, L., Cai, M., Gong, Z., Zhang, B., Li, Y., Guan, L., Hou, X., Li, Q., Liu, G., Xue, Z., Yang, M. H., Ye, J., Chin, Y. E. and You, H., 2017 FoxO3 inactivation promotes human cholangiocarcinoma tumorigenesis and chemoresistance via Keap1-Nrf2 signaling., Guan L, Zhang L, Gong Z, Hou X, Xu Y, Feng X, Wang H, You H., 2016 Chaperone-mediated autophagy prevents apoptosis by degrading BBC3/PUMA., Xie W, Zhang L, Jiao H, Guan L, Zha J, Li X, Wu M, Wang Z, Han J, You H., 2015 Chaperone-like protein p32 regulates ULK1 stability and autophagy., Jiao H, Su GQ, Dong W, Zhang L, Xie W, Yao LM, Chen P, Wang ZX, Liou YC, You H., 2015 TRIM39 regulates cell cycle progression and DNA damage responses via stabilizing p21., Zhang L, Mei Y, Fu NY, Guan L, Xie W, Liu HH, Yu CD, Yin Z, Yu VC, You H., 2012 Regulation of cell cycle progression by FOXO3 through a its binding partner Cdt1., Zhang YR, Xing Y, Zhang L, Mei Y, Yamamoto K, Mak TW, You H., 2012 Regulation of neuroblastoma differentiation by forkhead transcription factors FOXO 1/3/4 through the receptor tyrosine kinase PDGFRA., Mei Y, Wang Z，Zhang L, Zhang YR, Li XY, Liu HH, Ye J, You H., 2012 Mammalian target of rapamycin up-regulation of pyruvate kinase isoenzyme type M2 is critical for aerobic glycolysis and tumor growth., Sun Q, Chen X, Ma J, Peng H, Wang F, Zha X, Wang Y, Jing Y, Yang H, Chen R, Chang L, Zhang Y, Goto J, Onda H, Chen T, Wang MR, Lu Y, You H, Kwiatkowski D, Zhang H., 2011 FoxO3a -dependent regulation of Pink1/Park6 mediates survival signaling in response to cytokine deprivation., Mei Y, Zhang YR, Yamamoto K, Xie W, Mak TW, You H*., 2009

Areas of Focus

Reciprocal regulation between PI3K/AKT/FoxO pathway and epigenetic modulation mechanisms
Chemoresistance and cancer metastasis
Regulation of cell differentiation, apoptosis, and autophagy

Publications

A deregulated m6A writer complex axis driven by BRD4 confers an epitranscriptomic vulnerability in combined DNA repair-targeted therapy., Xiao Lu, Lichao Peng, Jiancheng Ding, Yuanpei Li, Qing Li, Mengchen Rao, Tong Shu, Xiaoniu He, Chen Liu, Jing Ye*, Wen Liu*, Han You*., 2023
METTL3 acetylation impedes cancer metastasis via fine-tuning its nuclear and cytosolic functions., Yuanpei Li, Xiaoniu He, Xiao Lu, Zhicheng Gong, Qing Li, Lei Zhang, Ronghui Yang, Chengyi Wu, Jialiang Huang, Jiancheng Ding, Yaohui He, Wen Liu, Ceshi Chen, Bin Cao, Dawang Zhou,YuFeng Shi, Juxiang Chen, Chuangui Wang, Shengping Zhang, Jian Zhang, Jing Ye, Han You*., 2022
OTUD7B Deubiquitinates LSD1 to Govern Its Binding Partner Specificity, Homeostasis and Breast Cancer Metastasis., Gong, Z., Li AC., Ding JC., Li, Q., Zhang L., Li YP., Meng Z., Chen F., Huang JL., Zhou DW., Hu RG., Ye, J., Liu W. and You, H*., 2021
Geminin facilitates FoxO3 deacetylation to promote breast cancer cell metastasis., Zhang, L., Cai, M., Gong, Z., Zhang, B., Li, Y., Guan, L., Hou, X., Li, Q., Liu, G., Xue, Z., Yang, M. H., Ye, J., Chin, Y. E. and You, H*., 2017
FoxO3 inactivation promotes human cholangiocarcinoma tumorigenesis and chemoresistance via Keap1-Nrf2 signaling., Guan L, Zhang L, Gong Z, Hou X, Xu Y, Feng X, Wang H, You H*., 2016
Chaperone-mediated autophagy prevents apoptosis by degrading BBC3/PUMA., Xie W, Zhang L, Jiao H, Guan L, Zha J, Li X, Wu M, Wang Z, Han J, You H*., 2015
Chaperone-like protein p32 regulates ULK1 stability and autophagy., Jiao H, Su GQ, Dong W, Zhang L, Xie W, Yao LM, Chen P, Wang ZX, Liou YC, You H*., 2015
TRIM39 regulates cell cycle progression and DNA damage responses via stabilizing p21., Zhang L, Mei Y, Fu NY, Guan L, Xie W, Liu HH, Yu CD, Yin Z, Yu VC, You H*., 2012
Regulation of cell cycle progression by FOXO3 through a its binding partner Cdt1., Zhang YR, Xing Y, Zhang L, Mei Y, Yamamoto K, Mak TW*, You H*., 2012
Regulation of neuroblastoma differentiation by forkhead transcription factors FOXO 1/3/4 through the receptor tyrosine kinase PDGFRA., Mei Y, Wang Z，Zhang L, Zhang YR, Li XY, Liu HH, Ye J, You H*., 2012
Mammalian target of rapamycin up-regulation of pyruvate kinase isoenzyme type M2 is critical for aerobic glycolysis and tumor growth., Sun Q, Chen X, Ma J, Peng H, Wang F, Zha X, Wang Y, Jing Y, Yang H, Chen R, Chang L, Zhang Y, Goto J, Onda H, Chen T, Wang MR, Lu Y, You H*, Kwiatkowski D, Zhang H*., 2011
FoxO3a -dependent regulation of Pink1/Park6 mediates survival signaling in response to cytokine deprivation., Mei Y, Zhang YR, Yamamoto K, Xie W, Mak TW*, You H*., 2009

Pi3K Akt Foxo Epigenetic Modulation Chemoresistance Cancer Metastasis Differentiation Apoptosis

Jun Huang - Zhejiang University

Renqing Feng - Peking University

Liang Chen - University of Chinese Academy of Sciences

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