Professor | 尤涵 | 数字化转型顾问

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Name	尤涵
Contact Information	hyou@xmu.edu.cn
Language ability	英语, 中文
Province	福建

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Name

尤涵

Contact Information

hyou@xmu.edu.cn

Language ability

英语, 中文

Province

福建

University/Lab Affiliation and Title	厦门大学
Faculty	Life Sciences
Academic Background & Achievements	1999 - 临床医疗专业学士/硕士学位: 第四军医大学 2002 - 临床医疗专业博士学位: 第四军医大学 2017 - 获得国家杰出青年科学基金资助
Work Experience	2000-2001 - 访问学者 - 波士顿大学生化系 2001-2003 - 访问学者 - 麻省理工学院肿瘤研究中心 2003-2007 - 博士后 - 加拿大多伦多大学 2007-至今 - 教授/博士生导师 - 厦门大学生命科学学院 2011-至今 - 副主任 - 细胞应激生物学国家重点实验室
Awards	2017: 国家杰出青年科学基金

University/Lab Affiliation and Title

厦门大学

Faculty

Life Sciences

Academic Background & Achievements

1999 - 临床医疗专业学士/硕士学位: 第四军医大学
2002 - 临床医疗专业博士学位: 第四军医大学
2017 - 获得国家杰出青年科学基金资助

Work Experience

2000-2001 - 访问学者 - 波士顿大学生化系
2001-2003 - 访问学者 - 麻省理工学院肿瘤研究中心
2003-2007 - 博士后 - 加拿大多伦多大学
2007-至今 - 教授/博士生导师 - 厦门大学生命科学学院
2011-至今 - 副主任 - 细胞应激生物学国家重点实验室

Awards

2017: 国家杰出青年科学基金

Areas of Focus	PI3K/AKT/FoxO通路与表观遗传修饰机制的互话肿瘤耐药和肿瘤转移细胞分化、细胞凋亡和细胞自噬的调控
Publications	A deregulated m6A writer complex axis driven by BRD4 confers an epitranscriptomic vulnerability in combined DNA repair-targeted therapy., Xiao Lu, Lichao Peng, Jiancheng Ding, Yuanpei Li, Qing Li, Mengchen Rao, Tong Shu, Xiaoniu He, Chen Liu, Jing Ye, Wen Liu, Han You., 2023 METTL3 acetylation impedes cancer metastasis via fine-tuning its nuclear and cytosolic functions., Yuanpei Li, Xiaoniu He, Xiao Lu, Zhicheng Gong, Qing Li, Lei Zhang, Ronghui Yang, Chengyi Wu, Jialiang Huang, Jiancheng Ding, Yaohui He, Wen Liu, Ceshi Chen, Bin Cao, Dawang Zhou,YuFeng Shi, Juxiang Chen, Chuangui Wang, Shengping Zhang, Jian Zhang, Jing Ye, Han You., 2022 OTUD7B Deubiquitinates LSD1 to Govern Its Binding Partner Specificity, Homeostasis and Breast Cancer Metastasis., Gong, Z., Li AC., Ding JC., Li, Q., Zhang L., Li YP., Meng Z., Chen F., Huang JL., Zhou DW., Hu RG., Ye, J., Liu W. and You, H., 2021 Geminin facilitates FoxO3 deacetylation to promote breast cancer cell metastasis., Zhang, L., Cai, M., Gong, Z., Zhang, B., Li, Y., Guan, L., Hou, X., Li, Q., Liu, G., Xue, Z., Yang, M. H., Ye, J., Chin, Y. E. and You, H., 2017 FoxO3 inactivation promotes human cholangiocarcinoma tumorigenesis and chemoresistance via Keap1-Nrf2 signaling., Guan L, Zhang L, Gong Z, Hou X, Xu Y, Feng X, Wang H, You H., 2016 Chaperone-mediated autophagy prevents apoptosis by degrading BBC3/PUMA., Xie W, Zhang L, Jiao H, Guan L, Zha J, Li X, Wu M, Wang Z, Han J, You H., 2015 Chaperone-like protein p32 regulates ULK1 stability and autophagy., Jiao H, Su GQ, Dong W, Zhang L, Xie W, Yao LM, Chen P, Wang ZX, Liou YC, You H., 2015 TRIM39 regulates cell cycle progression and DNA damage responses via stabilizing p21., Zhang L, Mei Y, Fu NY, Guan L, Xie W, Liu HH, Yu CD, Yin Z, Yu VC, You H., 2012 Regulation of cell cycle progression by FOXO3 through a its binding partner Cdt1., Zhang YR, Xing Y, Zhang L, Mei Y, Yamamoto K, Mak TW, You H., 2012 Regulation of neuroblastoma differentiation by forkhead transcription factors FOXO 1/3/4 through the receptor tyrosine kinase PDGFRA., Mei Y, Wang Z，Zhang L, Zhang YR, Li XY, Liu HH, Ye J, You H., 2012 Mammalian target of rapamycin up-regulation of pyruvate kinase isoenzyme type M2 is critical for aerobic glycolysis and tumor growth., Sun Q, Chen X, Ma J, Peng H, Wang F, Zha X, Wang Y, Jing Y, Yang H, Chen R, Chang L, Zhang Y, Goto J, Onda H, Chen T, Wang MR, Lu Y, You H, Kwiatkowski D, Zhang H., 2011 FoxO3a -dependent regulation of Pink1/Park6 mediates survival signaling in response to cytokine deprivation., Mei Y, Zhang YR, Yamamoto K, Xie W, Mak TW, You H*., 2009

Areas of Focus

PI3K/AKT/FoxO通路与表观遗传修饰机制的互话
肿瘤耐药和肿瘤转移
细胞分化、细胞凋亡和细胞自噬的调控

Publications

A deregulated m6A writer complex axis driven by BRD4 confers an epitranscriptomic vulnerability in combined DNA repair-targeted therapy., Xiao Lu, Lichao Peng, Jiancheng Ding, Yuanpei Li, Qing Li, Mengchen Rao, Tong Shu, Xiaoniu He, Chen Liu, Jing Ye*, Wen Liu*, Han You*., 2023
METTL3 acetylation impedes cancer metastasis via fine-tuning its nuclear and cytosolic functions., Yuanpei Li, Xiaoniu He, Xiao Lu, Zhicheng Gong, Qing Li, Lei Zhang, Ronghui Yang, Chengyi Wu, Jialiang Huang, Jiancheng Ding, Yaohui He, Wen Liu, Ceshi Chen, Bin Cao, Dawang Zhou,YuFeng Shi, Juxiang Chen, Chuangui Wang, Shengping Zhang, Jian Zhang, Jing Ye, Han You*., 2022
OTUD7B Deubiquitinates LSD1 to Govern Its Binding Partner Specificity, Homeostasis and Breast Cancer Metastasis., Gong, Z., Li AC., Ding JC., Li, Q., Zhang L., Li YP., Meng Z., Chen F., Huang JL., Zhou DW., Hu RG., Ye, J., Liu W. and You, H*., 2021
Geminin facilitates FoxO3 deacetylation to promote breast cancer cell metastasis., Zhang, L., Cai, M., Gong, Z., Zhang, B., Li, Y., Guan, L., Hou, X., Li, Q., Liu, G., Xue, Z., Yang, M. H., Ye, J., Chin, Y. E. and You, H*., 2017
FoxO3 inactivation promotes human cholangiocarcinoma tumorigenesis and chemoresistance via Keap1-Nrf2 signaling., Guan L, Zhang L, Gong Z, Hou X, Xu Y, Feng X, Wang H, You H*., 2016
Chaperone-mediated autophagy prevents apoptosis by degrading BBC3/PUMA., Xie W, Zhang L, Jiao H, Guan L, Zha J, Li X, Wu M, Wang Z, Han J, You H*., 2015
Chaperone-like protein p32 regulates ULK1 stability and autophagy., Jiao H, Su GQ, Dong W, Zhang L, Xie W, Yao LM, Chen P, Wang ZX, Liou YC, You H*., 2015
TRIM39 regulates cell cycle progression and DNA damage responses via stabilizing p21., Zhang L, Mei Y, Fu NY, Guan L, Xie W, Liu HH, Yu CD, Yin Z, Yu VC, You H*., 2012
Regulation of cell cycle progression by FOXO3 through a its binding partner Cdt1., Zhang YR, Xing Y, Zhang L, Mei Y, Yamamoto K, Mak TW*, You H*., 2012
Regulation of neuroblastoma differentiation by forkhead transcription factors FOXO 1/3/4 through the receptor tyrosine kinase PDGFRA., Mei Y, Wang Z，Zhang L, Zhang YR, Li XY, Liu HH, Ye J, You H*., 2012
Mammalian target of rapamycin up-regulation of pyruvate kinase isoenzyme type M2 is critical for aerobic glycolysis and tumor growth., Sun Q, Chen X, Ma J, Peng H, Wang F, Zha X, Wang Y, Jing Y, Yang H, Chen R, Chang L, Zhang Y, Goto J, Onda H, Chen T, Wang MR, Lu Y, You H*, Kwiatkowski D, Zhang H*., 2011
FoxO3a -dependent regulation of Pink1/Park6 mediates survival signaling in response to cytokine deprivation., Mei Y, Zhang YR, Yamamoto K, Xie W, Mak TW*, You H*., 2009

Pi3K Akt Foxo 表观遗传调控耐药癌症转移分化凋亡

莫萍丽 - 厦门大学

Area of Focus
癌症 | 信号 | Wnt | Notch | P53 | Dna修复 | Pi3K | 肿瘤 | 通路 | 治疗

冯仁青 - 北京大学

陈亮 - 中国科学院大学

Area of Focus
肿瘤 | 细胞 | 存活 | 凋亡 | 信号 | 通路 | 检测 | 治疗 | 癌症 | 研究

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