Professor | Xiaofen Chen | Asia Growth Partners

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Name	Xiaofen Chen
Contact Information	chenxf@xmu.edu.cn
Language ability	Chinese, English
Province	Fujian

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Name

Xiaofen Chen

Contact Information

chenxf@xmu.edu.cn

Language ability

Chinese, English

Province

Fujian

University/Lab Affiliation and Title	Xiamen University
Faculty	Medical
Academic Background & Achievements	2000–2004: Bachelor of Biological Sciences, Xiamen University 2004–2009: PhD in Biochemistry and Molecular Biology, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences
Work Experience	2009 - 2012: Postdoctoral Researcher, University of California, Los Angeles (UCLA) 2014 - 2015: Visiting Scholar, Mayo Clinic 2012.11 – 2018.10: Associate Professor, School of Medicine, Xiamen University 2018.11-present: Professor, School of Medicine, Xiamen University
Awards	National Excellent Young Scientist Fund Fujian Province New Century Excellent Talent Xiamen University Nanqiang Young Top-notch A Talent

University/Lab Affiliation and Title

Xiamen University

Faculty

Medical

Academic Background & Achievements

2000–2004: Bachelor of Biological Sciences, Xiamen University
2004–2009: PhD in Biochemistry and Molecular Biology, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences

Work Experience

2009 - 2012: Postdoctoral Researcher, University of California, Los Angeles (UCLA)
2014 - 2015: Visiting Scholar, Mayo Clinic
2012.11 – 2018.10: Associate Professor, School of Medicine, Xiamen University
2018.11-present: Professor, School of Medicine, Xiamen University

Awards

National Excellent Young Scientist Fund
Fujian Province New Century Excellent Talent
Xiamen University Nanqiang Young Top-notch A Talent

Areas of Focus	Neuroscience Alzheimer's Disease
Publications	TREM2 receptor protects against complement-mediated synaptic loss by binding to complement C1q during neurodegeneration., Zhong L, Sheng X, Wang W, Li Y, Zhuo R, Wang K, Zhang L, Hu DD, Hong Y, Chen L, Rao H, Li T, Chen M, Lin Z, Zhang YW, Wang X, Yan XX, Chen X, Bu G, Chen XF, 2023 Microglial repopulation reverses cognitive and synaptic deficits in an Alzheimer's disease model by restoring BDNF signaling., Wang W, Li Y, Ma F, Sheng X, Chen K, Zhuo R, Wang C, Zheng H, Zhang YW, Bu G, Chen XF, Zhong L, 2023 Human ApoE2 protects mice against Plasmodium berghei ANKA experimental cerebral malaria., Liang R, Rao H, Pang Q, Xu R, Jiao Z, Lin L, Li L, Zhong L, Zhang Y, Guo Y, Xiao N, Liu S, Chen XF, Su XZ, Li J, 2023 Identification of the minimal active soluble TREM2 sequence for modulating microglial phenotypes and amyloid pathology., Sheng X, Yao Y, Huang R, Xu Y, Zhu Y, Chen L, Zhang L, Wang W, Zhuo R, Can D, Chang CC, Zhang YW, Xu H, Bu G, Zhong L, Chen XF, 2021 Soluble TREM2 ameliorates pathological phenotypes by modulating microglial functions in an Alzheimer’s disease model., Zhong L, Xu Y, Zhuo R, Wang T, Wang K, Huang R, Wang D, Gao Y, Zhu Y, Sheng X, Chen K, Wang N, Zhu L, Can D, Martens YA, Shinohara M, Liu CC, Du D, Sun H, Wen L, Xu H, Bu G, Chen XF, 2019 Promoter-Enhancer Communication Occurs Primarily within Insulated Neighborhoods., Sun F, Chronis C, Kronenberg M, Chen XF, Su T, Lay FD, Plath K, Kurdistani SK, Carey MF, 2019 Amyloid-beta modulates microglial responses by binding to the triggering receptor expressed on myeloid cells 2 (TREM2)., Zhong L, Wang Z, Wang D, Wang Z, Martens YA, Wu L, Xu Y, Wang K, Li J, Huang R, Can D, Xu H, Bu G, Chen XF, 2018 Soluble TREM2 promotes microglial survival and induces inflammatory responses via distinct signaling pathways., Zhong L, Chen XF, Wang TT, Wang Z, Liao CY, Wang ZQ, Huang RZ, Wang DX, Li XX, Wu LB, Zheng HH, Painter M, Atagi Y, Liu CC, Zhang YW, Fryer, Xu H, Bu G, 2017 TREM2/DAP12 Complex Regulates Inflammatory Responses in Microglia via the JNK Signaling Pathway., Zhong L, Zhang ZL, Li XX, Liao CY, Mou PF, Wang TT, Wang ZQ, Wang Z, Wei M, Xu H, Bu G, Chen XF, 2017 LRP1 modulates the microglial immune response via regulation of JNK and NF-κB signaling pathways., Yang L, Liu CC, Zheng H, Kanekiyo T, Atagi Y, Jia L, Wang D, N'songo A, Can D, Xu H, Chen XF, Bu G, 2016 Apolipoprotein E epsilon 2 allele and low serum cholesterol as risk factors for gastric cancer in a Chinese Han population., Kang RR, Li P, Wang TT, Li XX, Wei ZC, Zhang ZL, Zhong L, Cao LL, Heckman MG, Zhang YW, Xu H, Huang CM, Bu G, Chen XF, 2016 A rapid and cost-effective method for genotyping apolipoprotein E gene polymorphism., Zhong L, Xie YZ, Cao TT, Wang Z, Wang T, Li X, Shen RC, Xu H, Bu G, Chen XF, 2016 DAP12 stabilizes the C-terminal fragment of the triggering receptor expressed on myeloid cells-2 (TREM2) and protects against LPS-induced pro-inflammatory response., Zhong L, Chen XF, Zhang ZL, Wang Z, Shi XZ, Xu K, Zhang YW, Xu H, Bu G, 2015 Transcriptional regulation and its misregulation in Alzheimer's disease., Chen XF, Zhang YW, Xu H, Bu G, 2013 Mediator and SAGA Have Distinct Roles in Pol II Preinitiation Complex Assembly and Function., Chen XF, Lehmann L., Lin J., Vashisht A., Schmidt, Ferrari R., Huang CY., McKee R., Mosley A., Plath K., Kurdistani S., Wohlschlegel J., Carey M., 2012 The Rpd3 Core Complex is a Chromatin Stabilization Module., Chen XF, Kuryan B., Kitada T., Tran N., Li B., Carey M., 2012 Telomere Recombination Accelerates Cellular Aging in Saccharomyces cerevisiae., Chen XF, Meng FL, Zhou JQ, 2009

Areas of Focus

Neuroscience
Alzheimer's Disease

Publications

TREM2 receptor protects against complement-mediated synaptic loss by binding to complement C1q during neurodegeneration., Zhong L, Sheng X, Wang W, Li Y, Zhuo R, Wang K, Zhang L, Hu DD, Hong Y, Chen L, Rao H, Li T, Chen M, Lin Z, Zhang YW, Wang X, Yan XX, Chen X, Bu G, Chen XF, 2023
Microglial repopulation reverses cognitive and synaptic deficits in an Alzheimer's disease model by restoring BDNF signaling., Wang W, Li Y, Ma F, Sheng X, Chen K, Zhuo R, Wang C, Zheng H, Zhang YW, Bu G, Chen XF, Zhong L, 2023
Human ApoE2 protects mice against Plasmodium berghei ANKA experimental cerebral malaria., Liang R, Rao H, Pang Q, Xu R, Jiao Z, Lin L, Li L, Zhong L, Zhang Y, Guo Y, Xiao N, Liu S, Chen XF, Su XZ, Li J, 2023
Identification of the minimal active soluble TREM2 sequence for modulating microglial phenotypes and amyloid pathology., Sheng X, Yao Y, Huang R, Xu Y, Zhu Y, Chen L, Zhang L, Wang W, Zhuo R, Can D, Chang CC, Zhang YW, Xu H, Bu G, Zhong L, Chen XF, 2021
Soluble TREM2 ameliorates pathological phenotypes by modulating microglial functions in an Alzheimer’s disease model., Zhong L, Xu Y, Zhuo R, Wang T, Wang K, Huang R, Wang D, Gao Y, Zhu Y, Sheng X, Chen K, Wang N, Zhu L, Can D, Martens YA, Shinohara M, Liu CC, Du D, Sun H, Wen L, Xu H, Bu G, Chen XF, 2019
Promoter-Enhancer Communication Occurs Primarily within Insulated Neighborhoods., Sun F, Chronis C, Kronenberg M, Chen XF, Su T, Lay FD, Plath K, Kurdistani SK, Carey MF, 2019
Amyloid-beta modulates microglial responses by binding to the triggering receptor expressed on myeloid cells 2 (TREM2)., Zhong L, Wang Z, Wang D, Wang Z, Martens YA, Wu L, Xu Y, Wang K, Li J, Huang R, Can D, Xu H, Bu G, Chen XF, 2018
Soluble TREM2 promotes microglial survival and induces inflammatory responses via distinct signaling pathways., Zhong L, Chen XF, Wang TT, Wang Z, Liao CY, Wang ZQ, Huang RZ, Wang DX, Li XX, Wu LB, Zheng HH, Painter M, Atagi Y, Liu CC, Zhang YW, Fryer, Xu H, Bu G, 2017
TREM2/DAP12 Complex Regulates Inflammatory Responses in Microglia via the JNK Signaling Pathway., Zhong L, Zhang ZL, Li XX, Liao CY, Mou PF, Wang TT, Wang ZQ, Wang Z, Wei M, Xu H, Bu G, Chen XF, 2017
LRP1 modulates the microglial immune response via regulation of JNK and NF-κB signaling pathways., Yang L, Liu CC, Zheng H, Kanekiyo T, Atagi Y, Jia L, Wang D, N'songo A, Can D, Xu H, Chen XF, Bu G, 2016
Apolipoprotein E epsilon 2 allele and low serum cholesterol as risk factors for gastric cancer in a Chinese Han population., Kang RR, Li P, Wang TT, Li XX, Wei ZC, Zhang ZL, Zhong L, Cao LL, Heckman MG, Zhang YW, Xu H, Huang CM, Bu G, Chen XF, 2016
A rapid and cost-effective method for genotyping apolipoprotein E gene polymorphism., Zhong L, Xie YZ, Cao TT, Wang Z, Wang T, Li X, Shen RC, Xu H, Bu G, Chen XF, 2016
DAP12 stabilizes the C-terminal fragment of the triggering receptor expressed on myeloid cells-2 (TREM2) and protects against LPS-induced pro-inflammatory response., Zhong L, Chen XF, Zhang ZL, Wang Z, Shi XZ, Xu K, Zhang YW, Xu H, Bu G, 2015
Transcriptional regulation and its misregulation in Alzheimer's disease., Chen XF, Zhang YW, Xu H, Bu G, 2013
Mediator and SAGA Have Distinct Roles in Pol II Preinitiation Complex Assembly and Function., Chen XF, Lehmann L., Lin J., Vashisht A., Schmidt, Ferrari R., Huang CY., McKee R., Mosley A., Plath K., Kurdistani S., Wohlschlegel J., Carey M., 2012
The Rpd3 Core Complex is a Chromatin Stabilization Module., Chen XF, Kuryan B., Kitada T., Tran N., Li B., Carey M., 2012
Telomere Recombination Accelerates Cellular Aging in Saccharomyces cerevisiae., Chen XF, Meng FL, Zhou JQ, 2009

Neuroscience Alzheimer'S Disease Microglia Apolipoprotein E Trem2 Cognitive Function Neurodegenerative Diseases Brain Homeostasis Synaptic Loss Bdnf Signaling

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