Professor | Xiaowen Lyu | Asia Growth Partners

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Name	Xiaowen Lyu
Contact Information	xiaowenlyu@xmu.edu.cn
Language ability	Chinese, English
Province	Fujian

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Name

Xiaowen Lyu

Contact Information

xiaowenlyu@xmu.edu.cn

Language ability

Chinese, English

Province

Fujian

University/Lab Affiliation and Title	Xiamen University
Faculty	Medical
Academic Background & Achievements	2001-2005 Bachelor of Science in Biotechnology: Nanjing Agricultural University 2005-2012 Ph.D. in Developmental Biology: Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences
Work Experience	2012-2013 Assistant Professor: Institute of Neuroscience, Chinese Academy of Sciences 2014-2020 Postdoctoral Researcher: Emory University, USA 2020-present Professor: School of Medicine, Xiamen University
Awards	Xiamen University Nanqiang Young Top Talent

University/Lab Affiliation and Title

Xiamen University

Faculty

Medical

Academic Background & Achievements

2001-2005 Bachelor of Science in Biotechnology: Nanjing Agricultural University
2005-2012 Ph.D. in Developmental Biology: Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences

Work Experience

2012-2013 Assistant Professor: Institute of Neuroscience, Chinese Academy of Sciences
2014-2020 Postdoctoral Researcher: Emory University, USA
2020-present Professor: School of Medicine, Xiamen University

Awards

Xiamen University Nanqiang Young Top Talent

Areas of Focus	Chromatin high-dimensional structure and function Directed differentiation of embryonic stem cells
Publications	Regulation of CTCF loop formation during pancreatic cell differentiation, Lyu X, Rowley MJ, Kulik MJ, Dalton S & Corces VG, 2023 Priming with LSD1 inhibitors promotes the persistence and antitumor effect of adoptively transferred T cells, Qiu F, Jiang P, Zhang G, An j, Ruan K, Lyu X#, Zhou J#, Sheng W#, 2024 Replication timing maintains the global epigenetic state in human cells, Klein KN#, Zhao PA#, Lyu X#, Sasaki T, Bartlett DA, Singh AM, Tasan I, Zhang M, Watts LP, Hiraga S, Natsume T, Zhou X, Baslan T, Leung D, Kanemaki MT, Donaldson AD, Zhao H, Dalton S, Corces VG, Gilbert DM, 2021 Roles of Polycomb Complexes in the Reconstruction of 3D Genome Architecture during Preimplantation Embryonic Development, Yu L, Shen H, Lyu X, 2022 Architectural Proteins and Pluripotency Factors Cooperate to Orchestrate the Transcriptional Response of hESCs to Temperature Stress, Lyu X, Rowley MJ, Corces VG, 2018 Widespread rearrangement of 3D chromatin organization underlies polycomb-mediated stress-induced silencing, Li L#, Lyu X#, Hou C#, Takenaka N, Nguyen HQ, Ong CT, Cubeñas-Potts C, Hu M, Lei EP, Bosco G, Qin ZS, Corces VG, 2015 Engineering 3D genome organization, Lyu X, Corces VG, 2019 Genome-wide roles of Foxa2 in directing liver specification, Xu C#, Lu X#, Chen EZ, He Z, Uyunbilig B, Li G, Ma Y, Hui L, Xie B, Gao Y, Ding X, Hu Y, Hu P, Han JD*, Wang X, 2012 Condensin II Counteracts Cohesin and RNA Polymerase II in the Establishment of 3D Chromatin Organization, Rowley MJ, Lyu X, Rana V, Ando-Kuri M, Karns R, Bosco G, and Corces VG, 2019 Evolutionarily Conserved Principles Predict 3D Chromatin Organization, Rowley MJ#, Nichols MH#, Lyu X, Ando-Kuri M, Rivera ISM, Hermetz K, Wang P, Ruan Y, Corces VG, 2017 Different enhancer classes in Drosophila bind distinct architectural proteins and mediate unique chromatin interactions and 3D architecture, Cubeñas-Potts C#, Rowley MJ#, Lyu X, Li G, Lei EP, Corces VG, 2017 Rapid Irreversible Transcriptional Reprogramming in Human Stem Cells Accompanied by Discordance between Replication Timing and Chromatin Compartment, Wilson K#, Dileep V#, Marchal C, Lyu X, Li B, Axel P, Bartlett D, Qin Z, Robins AJ, Schulz TC, Corces VG, Gilbert DM, 2019 Chromatin States in Mouse Sperm Correlate with Embryonic and Adult Regulatory Landscapes, Jung Y, Sauria MEG, Lyu X, Cheema MS, Ausio J, Taylor J, Corces VG, 2017 Local Genome Topology Can Exhibit an Incompletely Rewired 3D-Folding State during Somatic Cell Reprogramming, Beagan JA, Gilgenast TG, Kim J, Plona Z, Norton HK, Hu G, Hsu SC, Shields EJ, Lyu X, Apostolou E, Hochedlinger K, Corces VG, Dekker J, Phillips-Cremins JE, 2016 Maintenance of CTCF- and transcription factor-mediated interactions from gametes to the early mouse embryo, Jung YH, Gold HB, Kremsky I, Rowley MJ, Punyawai K, Buonanotte A, Lyu X, Bixler BJ, Chan AWS, and Corces VG, 2019 Ecdysone-Induced 3D Chromatin Reorganization Involves Active Enhancers Bound by Pipsqueak and Polycomb, Gutierrez-Perez I#, Rowley MJ#, Lyu X, Valadez-Graham V, Ballesta-Illan E, Lopez-Atalaya JP, Kremsky IJ, Vallejo DM, Caparros E, Corces VG, Dominguez M, 2019

Areas of Focus

Chromatin high-dimensional structure and function
Directed differentiation of embryonic stem cells

Publications

Regulation of CTCF loop formation during pancreatic cell differentiation, Lyu X*, Rowley MJ, Kulik MJ, Dalton S & Corces VG*, 2023
Priming with LSD1 inhibitors promotes the persistence and antitumor effect of adoptively transferred T cells, Qiu F, Jiang P, Zhang G, An j, Ruan K, Lyu X#, Zhou J#, Sheng W#, 2024
Replication timing maintains the global epigenetic state in human cells, Klein KN#, Zhao PA#, Lyu X#, Sasaki T, Bartlett DA, Singh AM, Tasan I, Zhang M, Watts LP, Hiraga S, Natsume T, Zhou X, Baslan T, Leung D, Kanemaki MT, Donaldson AD, Zhao H, Dalton S, Corces VG, Gilbert DM, 2021
Roles of Polycomb Complexes in the Reconstruction of 3D Genome Architecture during Preimplantation Embryonic Development, Yu L, Shen H, Lyu X*, 2022
Architectural Proteins and Pluripotency Factors Cooperate to Orchestrate the Transcriptional Response of hESCs to Temperature Stress, Lyu X, Rowley MJ, Corces VG, 2018
Widespread rearrangement of 3D chromatin organization underlies polycomb-mediated stress-induced silencing, Li L#, Lyu X#, Hou C#, Takenaka N, Nguyen HQ, Ong CT, Cubeñas-Potts C, Hu M, Lei EP, Bosco G, Qin ZS, Corces VG, 2015
Engineering 3D genome organization, Lyu X, Corces VG, 2019
Genome-wide roles of Foxa2 in directing liver specification, Xu C#, Lu X#, Chen EZ, He Z, Uyunbilig B, Li G, Ma Y, Hui L, Xie B, Gao Y, Ding X, Hu Y, Hu P*, Han JD*, Wang X, 2012
Condensin II Counteracts Cohesin and RNA Polymerase II in the Establishment of 3D Chromatin Organization, Rowley MJ, Lyu X, Rana V, Ando-Kuri M, Karns R, Bosco G, and Corces VG, 2019
Evolutionarily Conserved Principles Predict 3D Chromatin Organization, Rowley MJ#, Nichols MH#, Lyu X, Ando-Kuri M, Rivera ISM, Hermetz K, Wang P, Ruan Y, Corces VG, 2017
Different enhancer classes in Drosophila bind distinct architectural proteins and mediate unique chromatin interactions and 3D architecture, Cubeñas-Potts C#, Rowley MJ#, Lyu X, Li G, Lei EP, Corces VG, 2017
Rapid Irreversible Transcriptional Reprogramming in Human Stem Cells Accompanied by Discordance between Replication Timing and Chromatin Compartment, Wilson K#, Dileep V#, Marchal C, Lyu X, Li B, Axel P, Bartlett D, Qin Z, Robins AJ, Schulz TC, Corces VG, Gilbert DM, 2019
Chromatin States in Mouse Sperm Correlate with Embryonic and Adult Regulatory Landscapes, Jung Y, Sauria MEG, Lyu X, Cheema MS, Ausio J, Taylor J, Corces VG, 2017
Local Genome Topology Can Exhibit an Incompletely Rewired 3D-Folding State during Somatic Cell Reprogramming, Beagan JA, Gilgenast TG, Kim J, Plona Z, Norton HK, Hu G, Hsu SC, Shields EJ, Lyu X, Apostolou E, Hochedlinger K, Corces VG, Dekker J, Phillips-Cremins JE, 2016
Maintenance of CTCF- and transcription factor-mediated interactions from gametes to the early mouse embryo, Jung YH, Gold HB, Kremsky I, Rowley MJ, Punyawai K, Buonanotte A, Lyu X, Bixler BJ, Chan AWS, and Corces VG, 2019
Ecdysone-Induced 3D Chromatin Reorganization Involves Active Enhancers Bound by Pipsqueak and Polycomb, Gutierrez-Perez I#, Rowley MJ#, Lyu X, Valadez-Graham V, Ballesta-Illan E, Lopez-Atalaya JP, Kremsky IJ, Vallejo DM, Caparros E, Corces VG, Dominguez M, 2019

Chromatin Epigenetics Gene Expression Enhancers Insulators Stem Cells Differentiation Transcription Genome Cell Fate

Hongqing Liang - Zhejiang University

Dawei Huo - Zhejiang University

Xuekun Li - Zhejiang University

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