1996 - Doctorate: Institute of Biophysics, Chinese Academy of Sciences
1996-1999 - Postdoctoral Researcher: California Institute of Technology, USA
1999-2002 - Postdoctoral Researcher: Mount Sinai Hospital Research Institute, Canada
2002-2008 - Senior Research Associate: Mount Sinai Hospital Research Institute, Canada
2008-present - Distinguished Professor: Xiamen University
Research
Protein ubiquitination and tumor development
Smurf1 aggravates non-alcoholic fatty liver disease by stabilizing SREBP-1c in an E3 activity-independent manner., Zhang X, Zhan Y, Lin W, Zhao F, Guo C, Chen Y, Du M, Li D, Zhang L, An W, Wang HR, Xie P, 2020
Mono-ubiquitination of p120-catenin is essential for TGFb-induced epithelial-mesenchymal transition and tumor metastasis., Wu Q, Li G, Wen C, Zeng T, Fan Y, Liu C, Fu GF, Xie C, Lin Q, Xie L, Huang L, Pu P, Ouyang Z, Chan HL, Zhao TJ, Chen XL, Fu G, Wang HR, 2020
A cell-based high-throughput screening method based on a ubiquitin-reference technique for identifying modulators of E3 ligases., Tian M, Zeng T, Han S, Lin H, Lin Q, Li L, Jiang T, Li G, Zhang T, Kang Q, Deng X, Wang HR, 2019
DHHC4 and DHHC5 Facilitate Fatty Acid Uptake by Palmitoylating and Targeting CD36 to the Plasma Membrane., Wang J, Hao JW, Wang X, Guo H, Sun HH, Lai XY, Liu LY, Zhu M, Wang HY, Li YF, Yu LY, Xie C, Wang HR, Mo W, Zhou HM, Chen S, Liang G, Zhao TJ, 2019
ATR/Chk1 signaling induces autophagy through sumoylated RhoB-mediated lysosomal translocation of TSC2 after DNA damage., Liu M, Zeng T, Zhang X, Liu C, Wu Z, Yao L, Xie C, Xia H, Lin Q, Xie L, Zhou D, Deng X, Chan HL, Zhao TJ, Wang HR, 2018
Targeting BRK-Positive Breast Cancers with Small-Molecule Kinase Inhibitors., Jiang J, Gui F, He Z, Li L, Li Y, Li S, Wu X, Deng Z, Sun X, Huang X, Huang W, Han S, Zhang T, Wang Z, Jiao B, Song S, Wang H, Chen L, Zhou D, Liu Q, Ren R, Zhang J, Deng X, 2017
IL-36γ Transforms the Tumor Microenvironment and Promotes Type 1 Lymphocyte-Mediated Antitumor Immune Responses., Wang X, Zhao X, Feng C, Weinstein A, Xia R, Wen W, Lv Q, Zuo S, Tang P, Yang X, Chen X, Wang H, Zang S, Stollings L, Denning TL, Jiang J, Fan J, Zhang G, Zhang X, Zhu Y, Storkus W, Lu B, 2015
Integration of Hippo signalling and the unfolded protein response to restrain liver overgrowth and tumorigenesis., Wu H, Wei L, Fan F, Ji S, Zhang S, Geng J, Hong L, Fan X, Chen Q, Tian J, Jiang M, Sun X, Jin C, Yin ZY, Liu Q, Zhang J, Qin F, Lin KH, Yu JS, Deng X, Wang HR, Zhao B, Johnson RL, Chen L, Zhou D, 2015
Kinases Mst1 and Mst2 positively regulate phagocytic induction of reactive oxygen species and bactericidal activity., Geng J, Sun X, Wang P, Zhang S, Wang X, Wu H, Hong L, Xie C, Li X, Zhao H, Liu Q, Jiang M, Chen Q, Zhang J, Li Y, Song S, Wang HR, Zhou R, Johnson RL, Chien KY, Lin SC, Han J, Avruch J, Chen L, Zhou D, 2015
ATR/Chk1/Smurf1 pathway determines cell fate after DNA damage by controlling RhoB abundance., Wang M, Guo L, Wu Q, Zeng T, Lin Q, Qiao Y, Wang Q, Liu M, Zhang X, Ren L, Zhang S, Pei Y, Yin Z, Ding F, Wang HR, 2014
The covalent modifier Nedd8 is critical for the activation of Smurf1 ubiquitin ligase in tumorigenesis., Xie P, Zhang M, He S, Lu K, Chen Y, Xing G, Lu Y, Liu P, Li Y, Wang S, Chai N, Wu J, Deng H, Wang HR, Cao Y, Zhao F, Cui Y, Wang J, He F, Zhang L, 2014
Impeded Nedd4-1-mediated Ras degradation underlies Ras-driven tumorigenesis., Zeng T, Wang Q, Fu J, Lin Q, Bi J, Ding W, Qiao Y, Zhang S, Zhao W, Lin H, Wang M, Lu B, Deng X, Zhou D, Yin Z, Wang HR, 2014
PKA/Smurf1 signaling-mediated stabilization of Nur77 is required for anticancer drug cisplatin-induced apoptosis., Lin H, Lin Q, Liu M, Lin Y, Wang X, Chen H, Xia Z, Lu B, Ding F, Wu Q, Wang HR, 2014
Ubiquitination in Rho signaling., Ding F, Yin Z, Wang HR, 2011
Binding of RhoA by the C2 domain of E3 ligase Smurf1 is essential for Smurf1-regulated RhoA ubiquitination and cell protrusive activity., Tian M, Bai C, Lin Q, Lin H, Liu M, Ding F, Wang HR, 2011
Autoinhibition of the HECT-type ubiquitin ligase Smurf2 through its C2 domain., Wiesner S, Ogunjim AA, Wang HR, Rotin D, Sicheri F, Wrana JL, Forman-Kay JD, 2007
Degradation of RhoA by Smurf1 ubiquitin ligase., Wang HR, Ogunjimi AA, Zhang Y, Ozdamar B, Bose R, Wrana JL, 2006
Regulation of the polarity protein Par6 by TGFbeta receptors controls epithelial cell plasticity., Ozdamar B, Bose R, Barrios-Rodiles M, Wang HR, Zhang Y, Wrana JL, 2005
Smurf1: a link between cell polarity and ubiquitination., Zhang Y, Wang HR, Wrana JL, 2004
Regulation of cell polarity and protrusion formation by targeting RhoA for degradation., Wang HR, Zhang Y, Ozdamar B, Ogunjimi AA, Alexandrova E, Thomsen GH, Wrana JL, 2003
TGF-beta induces assembly of a Smad2-Smurf2 ubiquitin ligase complex that targets SnoN for degradation., Bonni S, Wang HR, Causing CG, Kavsak P, Stroschein SL, Luo K, Wrana JL, 2001
Area of Focus
Autophagy | Neurological Diseases | Cancer | Autoimmune Diseases | Substrate Degradation | Small Molecules | Ai | Drug Screening | Mechanisms | Functions
