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Hao Yin
Immunology and Metabolion
Wuhan University
Hubei
Language: English, Chinese
Crispr
Cas9
Gene Therapy
Genetic Engineering
Molecular Biology
Biotechnology
Rna
Dna
Cell Therapy
Genomics
Areas of Focus
- Gene Editing
- RNA Therapy
Work Experience
- 2010-2016 Postdoctoral Researcher: MIT, Supervisors: Robert Langer and Daniel Anderson
- 2016-2018 Researcher: Forte Pharmaceuticals, USA
- 2018-Present Professor: Wuhan University Medical Research Institute
Academic Background & Achievements
- 1999-2003 Bachelor: Nanjing University, School of Life Sciences
- 2004-2010 PhD: University of Colorado Medical Center, Supervisor: Cynthia Ju
Publications
- Fast and Sensitive CRISPR Detection by Minimized Interference of Target Amplification, Hao Yin
- Enhancement of the viability of T cells electroporated with DNA via osmotic dampening of the DNA-sensing cGAS-STING pathway, Hao Yin
- Efficient targeted insertion of large DNA fragments without DNA donor, Hao Yin
- Fast and sensitive detection of SARS-CoV-2 RNA using suboptimal protospacer adjacent motifs for Cas12a, Hao Yin
- Eliminating base-editor-induced genome-wide and transcriptome-wide off-target mutations, Hao Yin
- Adenine base editing in an adult mouse model of tyrosinaemia, Hao Yin
- Rapid detection of African swine fever virus using Cas12a-based portable paper diagnostics, Hao Yin
- CRISPR-Cas: a tool for cancer research and therapeutics, Hao Yin
- Recent advances in chemical modifications of guide RNA, mRNA and donor template for CRISPR-mediated genome editing, Hao Yin
- Engineering guide RNA to reduce the off-target effects of CRISPR, Hao Yin, 2019
- Genome Editing with mRNA Encoding ZFN, TALEN, and Cas9, Hao Yin, 2019
- Partial DNA-guided Cas9 enables genome editing with reduced off-target activity, Hao Yin
- Structure-guided chemical modification of guide RNA enables potent non-viral in vivo genome editing, Hao Yin
- Delivery technologies for genome editing, Hao Yin
- Therapeutic genome editing by combined viral and non-viral delivery of CRISPR system components in vivo, Hao Yin
- RNAi-nanoparticulate manipulation of gene expression as a new functional genomics tool in the liver, Hao Yin
- Precision cancer mouse models through genome editing with CRISPR-Cas9, Hao Yin
- Genome editing with Cas9 in adult mice corrects a disease mutation and phenotype, Hao Yin
- CRISPR-mediated direct mutation of cancer genes in the mouse liver, Hao Yin
- Non-viral vectors for gene-based therapy, Hao Yin
- Nanoparticle-formulated siRNA targeting integrins inhibits hepatocellular carcinoma progression in mice, Hao Yin
- Lactoferrin protects against acetaminophen-induced liver injury in mice, Hao Yin
- Prostaglandin I(2) and E(2) mediate the protective effects of cyclooxygenase-2 in a mouse model of immune-mediated liver injury, Hao Yin
Awards
- 2018 National High-level Talents Youth Project
