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Zhong Bo
Immunology and Metabolion
Wuhan University
Hubei
Language: English, Chinese
Immunity
Virus
Inflammation
Tumor
Metastasis
Molecular Mechanisms
Gene Regulation
Protein Function
Disease Models
Therapeutic Targets
Areas of Focus
- Antiviral immunity
- Inflammatory responses
- Tumor development and metastasis
Work Experience
- 2010.7 - 2013.2 Postdoctoral Researcher, UT MD Anderson Cancer Center, Supervisor: Dong Chen
- 2013.3 - present Professor, Wuhan University, School of Life Sciences and Medical Research Institute, Virology State Key Laboratory
Academic Background & Achievements
- 2001.9 - 2005.6 Bachelor in English, China University of Geosciences
- 2003.2 - 2005.6 Bachelor in Biological Sciences, Wuhan University
- 2005.9 - 2010.6 PhD in Cell Biology, Wuhan University, Supervisor: Shu Hongbing
Publications
- The E3 ubiquitin ligase ARIH1 promotes antiviral immunity and autoimmunity by inducing mono-ISGylation and oligomerization of cGAS, Zhong B*
- USP2 promotes experimental colitis and bacterial infections by inhibiting the proliferation of myeloid cells and remodeling the extracellular matrix network, Zhong B*, 2022
- RNF115 inhibits the post-ER trafficking of TLRs and TLRs-mediated immune responses by catalyzing K11-linked ubiquitination of RAB1A and RAB13, Zhong B*, 2022
- IL-36g and IL-36Ra reciprocally regulate colon tumorigenesis by modulating the cell-matrix adhesion network and Wnt signaling, Zhong B*, 2022
- Regulation and function of the cGAS-MITA/STING axis in health and disease, Zhong B*, 2022
- The industrial solvent 1,4-Dioxane causes hyperalgesia by targeting capsaicin receptor TRPV1, Mo X, Liu Q, Gao L, Xie C, Wei X, Pang P, Tian Q, Gao Y, Zhang Y, Wang Y, Xiong T, Zhong B, Li D, Yao J*, 2022
- IL-36g and IL-36Ra reciprocally regulate NSCLC progression by modulating GSH homeostasis and oxidative stress-induced cell death, Wang P, Yang W, Guo H, Dong HP, Guo YY, Gan H, Wang Z, Cheng Y, Deng Y, Xie S, Yang X, Lin D*, Zhong B*, 2021
- Epigenetic Dysregulation Induces Translocation of Histone H3 into Cytoplasm, Wang Z, Chen J, Gao C, Xiao S, Wang XW, Tang SB, Li QL, Zhong B, Song ZY, Shu HB, Li LY, Wu M*, 2021
- Histone deacetylase 3 promotes innate antiviral immunity through deacetylation of TBK1, Tang JL, Yang Q, Xu CH, Zhao H, Liu YL, Liu CY, Zhou Y, Gai DW, Pei RJ, Wang Y, Hu X, Zhong B, Wang YY, Chen XW*, Chen JZ*, 2021
- SOSTDC1-producing follicular helper T cells promote regulatory follicular T cell differentiation, Wu X, Wang Y, Huang R, Gai Q, Liu H, Shi M, Zhang X, Zuo Y, Chen L, Zhao Q, Shi Y, Wang F, Yan X, Lu H, Xu S, Yao X, Chen L, Zhang X, Tian Y, Yang Z, Zhong B, Dong C, Wang Y*, Bian XW*, Liu X*, 2020
- CCL7 recruits cDC1 to promote antitumor immunity and facilitate checkpoint immunotherapy to non-small cell lung cancer, Zhang M, Yang W, Wang P, Deng Y, Dong YT, Liu FF, Huang R, Zhang P, Duan YQ, Liu XD, Lin D*, Chu Q*, Zhong B*, 2020
- RNF115 plays dual roles in innate antiviral responses by catalyzing distinct ubiquitination of MAVS and MITA, Zhang ZD, Xiong TC, Yao SQ, Wei MC, Chen M, Lin D, Zhong B*, 2020
- The deubiquitinase USP25 supports colonic inflammation and bacterial infection and promotes colorectal cancer, Wang XM, Yang C, Zhao Y, Xu Z, Yang W, Wang P, Lin D, Xiong B, Fang J, Dong C, Zhong B*, 2020
- USP29 maintains the stability of cGAS and promotes cellular antiviral responses and autoimmunity, Zhang Q, Tang Z, An R, Ye L, Zhong B*, 2020
- Dispensable role of CCL28 in Kras-mutated non-small cell lung cancer mouse models, Lin D*, Zhang M, Guo H, Deng Y, Zhong B, Liao F*, Xu ZG*, 2020
- USP22 promotes IRF3 nuclear translocation and antiviral responses by deubiquitinating the importin protein KPNA2, Cai Z, Zhang MX, Tang Z, Zhang Q, Ye J, Xiong TC, Zhang ZD, Zhong B*, 2020
- RNA based mNGS approach identifies a novel human coronavirus from two individual pneumonia cases in 2019 Wuhan outbreak, Chen L, Liu W, Zhang Q, Xu K, Ye G, Wu W, Sun Z, Liu F, Wu K, Zhong B, Mei Y, Zhang W, Chen Y*, Li Y*, Shi M*, Lan K*, Liu Y*, 2020
- Phosphorylation of MAVS/VISA by Nemo-like kinase (NLK) for degradation regulates the antiviral innate immune response, Li SZ*, Shu QP, Song Y, Zhang HH, Liu Y, Jin BX, Liuyu TZ, Li C, Huang XC, Du RL, Song W*, Zhong B*, Zhang XD*, 2019
- Genome-wide analysis identifies NR4A1 as a key mediator of T cell dysfunction, Liu X*, Wang Y, Lu H, Li J, Yan X, Xiao M, Hao J, Alekseev A, Khong H, Chen T, Huang R, Wu J, Zhao Q, Wu Q, Xu S, Wang X, Jin W, Yu S, Wang Y, Wei L, Wang A, Zhong B, Ni L, Liu X*, Nurieva R, Ye L, Tian Q, Bian XW*, Dong C*, 2019
- Recovery from tachyphylaxis of TRPV1 coincides with recycling to the surface membrane, Tian Q, Hu J, Xie C, Mei K, Pham C, Mo X, Hepp R, Soares S, Nothias F, Wang Y, Liu Q, Cai F, Zhong B, Li D, Yao J, 2019
- USP49 negatively regulates cellular antiviral responses via deconjugating K63-linked ubiquitination of MITA, Ye L, Zhang Q, Liuyu T, Xu Z, Zhang MX, Luo MH, Zeng WB, Zhu Q, Lin D*, Zhong B*, 2019
- USP20 promotes cellular antiviral responses via deconjugating K48-linked ubiquitination of MITA, Zhang MX, Cai Z, Zhang M, Wang XM, Wang Y, Zhao F, Zhou J, Luo MH, Zhu Q, Xu Z, Zeng WB*, Zhong B*, Lin D*, 2019
- Induction of OTUD4 by viral infection promotes antiviral responses through deubiquitinating and stabilizing MAVS, Liuyu T, Yu K, Ye L, Zhang Z, Zhang M, Ren Y, Cai Z, Zhu Q, Lin D, Zhong B*, 2019
- USP19 Inhibits TNF-α– and IL-1β–Triggered NF-κB Activation by Deubiquitinating TAK1, Lei CQ, Wu X, Zhong X, Jiang L, Zhong B, Shu HB*, 2019
- USP2a supports metastasis by tuning TGF-b signaling, Zhao Y, Wang XM, Wang Q, Deng Y, Li K, Zhang M, Zhang Q
Awards
- 2020 Gu Xiaocheng Lecture Award
- 2020 Laboratory Travel Grant, American Society of Immunologists, USA
- 2017 Young Researcher Nominee Award, Chinese Society for Cell Biology
- 2017 Outstanding Young Scholar Award, Hubei Province Society for Cell Biology
- 2016 Zhu Yubi Medical Award, Wuhan University
- 2015 National Natural Science Second Prize (Second Author)
- 2015 Top Ten Outstanding Youths, Wuhan University
- 2014 Selected for the Fifth Batch of Qingnian Qianren Plan
- 2012 National Top 100 Excellent PhD Thesis, China
- 2012 Abstract Award, American Society of Immunologists, USA
- 2011 Odyssey Fellowship, MD Anderson Cancer Center
- 2010 Invited to the 60th Nobel Laureate Meeting, Germany
- 2009 Wu Rui Award, Wu Rui Foundation, USA
