Professor | Hai-Liang Hu | Asia Growth Partners

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Name	Hai-Liang Hu
Contact Information	huhl@sustech.edu.cn
Language ability	English, Chinese
Province	Guangdong

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Name

Hai-Liang Hu

Contact Information

huhl@sustech.edu.cn

Language ability

English, Chinese

Province

Guangdong

University/Lab Affiliation and Title	Southern University of Science and Technology
Faculty	Medical School
Academic Background & Achievements	1991-1995 Bachelor of Science in Chemistry: Nankai University 1995-2000 Doctor of Science in Biochemistry and Molecular Biology: Shanghai Institute of Biochemistry, Chinese Academy of Sciences Doctoral Supervisor: Academician Hong Guofan Received the Excellent Doctoral Student P&G Award
Work Experience	2001-2007 Postdoctoral Researcher: UCLA School of Medicine 2007-2012 Assistant Researcher: UCLA School of Medicine 2012-2016 Research Assistant Professor: UCLA School of Medicine 2016-2020 Assistant Professor: Duke University School of Medicine 2020- Associate Professor, Associate Researcher: Southern University of Science and Technology School of Medicine
Awards	2019 DoD Prostate Cancer Research Program (PCRP) Fund Review Expert 2018 PCF Valor Challenge Award 2011 California Breast Cancer Research Program (BCRP) Young Investigator Award 2003 UCLA JCCF Postdoctoral Research Fellowship Award 2000 Chinese Academy of Sciences Excellent Doctoral P&G Award

University/Lab Affiliation and Title

Southern University of Science and Technology

Faculty

Medical School

Academic Background & Achievements

1991-1995 Bachelor of Science in Chemistry: Nankai University
1995-2000 Doctor of Science in Biochemistry and Molecular Biology: Shanghai Institute of Biochemistry, Chinese Academy of Sciences
Doctoral Supervisor: Academician Hong Guofan
Received the Excellent Doctoral Student P&G Award

Work Experience

2001-2007 Postdoctoral Researcher: UCLA School of Medicine
2007-2012 Assistant Researcher: UCLA School of Medicine
2012-2016 Research Assistant Professor: UCLA School of Medicine
2016-2020 Assistant Professor: Duke University School of Medicine
2020- Associate Professor, Associate Researcher: Southern University of Science and Technology School of Medicine

Awards

2019 DoD Prostate Cancer Research Program (PCRP) Fund Review Expert
2018 PCF Valor Challenge Award
2011 California Breast Cancer Research Program (BCRP) Young Investigator Award
2003 UCLA JCCF Postdoctoral Research Fellowship Award
2000 Chinese Academy of Sciences Excellent Doctoral P&G Award

Areas of Focus	DNA damage and repair, tumor metabolism and targeted therapy Prostate cancer hormone therapy resistance and neuroendocrine small cell carcinoma Role of non-coding RNA in tumor occurrence, growth, and migration Development of human induced pluripotent stem cells (hiPSC) for studying neurodegenerative rare diseases
Publications	An Isoform switch of glutaminase drives therapeutic resistance and disease progression of prostate cancer, Hu H, Huang J, 2020 N-Myc promotes therapeutic resistance development of neuroendocrine prostate cancer by differentially regulating miR-421/ATM pathway, Hu H, Huang J, 2019 ATM deficiency promotes progression of castration resistant prostate cancer by enhancing Warburg effect, Hu H, Huang J, 2019 ATM-dependent MiR-335 targets CtIP and modulates the DNA damage response, Hu H, 2013 SMRT compounds abrogate cellular phenotypes of ataxia telangiectasia in neural derivatives of patient-specific hiPSCs, Hu H, Lowry WE, 2013 MicroRNAs: new players in the DNA damage response, Hu H, 2011 ATM is down-regulated by N-Myc-regulated microRNA-421, Hu H*, 2010 New approaches to treatment of primary immunodeficiencies: fixing mutations with chemicals, Hu H, 2008 Integration of transforming growth factor beta and RAS signaling silences a RAB5 guanine nucleotide exchange factor and enhances growth factor-directed cell migration, Hu H, 2008 RIN1 is an ABL tyrosine kinase activator and a regulator of epithelial-cell adhesion and migration, Hu H, 2005 In Rhizobium leguminosarum, NodD represses its own transcription by competing with RNA polymerase for binding sites, Hu H, 2000

Areas of Focus

DNA damage and repair, tumor metabolism and targeted therapy
Prostate cancer hormone therapy resistance and neuroendocrine small cell carcinoma
Role of non-coding RNA in tumor occurrence, growth, and migration
Development of human induced pluripotent stem cells (hiPSC) for studying neurodegenerative rare diseases

Publications

An Isoform switch of glutaminase drives therapeutic resistance and disease progression of prostate cancer, Hu H*, Huang J*, 2020
N-Myc promotes therapeutic resistance development of neuroendocrine prostate cancer by differentially regulating miR-421/ATM pathway, Hu H*, Huang J*, 2019
ATM deficiency promotes progression of castration resistant prostate cancer by enhancing Warburg effect, Hu H*, Huang J*, 2019
ATM-dependent MiR-335 targets CtIP and modulates the DNA damage response, Hu H*, 2013
SMRT compounds abrogate cellular phenotypes of ataxia telangiectasia in neural derivatives of patient-specific hiPSCs, Hu H*, Lowry WE*, 2013
MicroRNAs: new players in the DNA damage response, Hu H*, 2011
ATM is down-regulated by N-Myc-regulated microRNA-421, Hu H*, 2010
New approaches to treatment of primary immunodeficiencies: fixing mutations with chemicals, Hu H, 2008
Integration of transforming growth factor beta and RAS signaling silences a RAB5 guanine nucleotide exchange factor and enhances growth factor-directed cell migration, Hu H, 2008
RIN1 is an ABL tyrosine kinase activator and a regulator of epithelial-cell adhesion and migration, Hu H, 2005
In Rhizobium leguminosarum, NodD represses its own transcription by competing with RNA polymerase for binding sites, Hu H, 2000

Dna Repair Tumor Metabolism Targeted Therapy Prostate Cancer Hormone Therapy Resistance Neuroendocrine Carcinoma Non-Coding Rna Tumor Migration Hipsc Neurodegenerative Diseases

Shuangli Mi - University of Chinese Academy of Sciences

Hongmei Liu - University of Chinese Academy of Sciences

Miguel Angel Esteban - University of Chinese Academy of Sciences

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