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Linquan Bai
Life Science
Shanghai Jiao Tong University
Shanghai
Language: English, Chinese, German
Biosynthesis
Jinggangmycin
Validamycin
Ansamycin
Antibiotics
Bioprospecting
Gene Resources
Secondary Metabolites
Rice Sheath Blight
Antibiotic Research
Areas of Focus
- Biosynthesis of Jinggangmycin/Validamycin
- Biosynthetic mechanisms and combinatorial biosynthesis of ansamycin antibiotics
- Bioprospecting of secondary metabolite biosynthetic gene resources
- Research on the rice sheath blight antibiotic Jinggangmycin
Work Experience
- 1999-2002 Postdoctoral Researcher, Department of Chemistry, University of Washington, USA
- 2006-2007 Research on biosynthetic regulation at the Microbiology Institute, University of Tuebingen, Germany
Academic Background & Achievements
- 1992 Bachelor of Science in Microbiology, Shandong University
- 1995 Master of Science in Microbiology, Huazhong Agricultural University
- 1998 Doctor of Science in Molecular Biology, Huazhong Agricultural University
Publications
- Structural and functional analysis of validoxylamine A 7'-phosphate synthase ValL involved in validamycin A biosynthesis, Zheng L, Zhou X, Zhang H, Ji X, Li L, Huang L, Bai L*, Zhang H*, 2012
- Unveiling the biosynthetic puzzle of destruxins in Metarhizium species, Wang B, Kang Q, Lu Y, Bai L, Wang C, 2012
- Dual carbamoylations on the polyketide and glycosyl moiety by asm21 result in extended ansamitocin biosynthesis, Li Y, Zhao P, Kang Q, Ma J, Bai L*, Deng Z, 2011
- Biosynthesis of 3,5-AHBA-derived natural products, Kang Q, Shen Y, Bai L*, 2012
- Cloning and characterization of the polyether salinomycin biosynthesis gene cluster of Streptomyces albus XM211, Jiang C, Wang H, Kang Q, Liu J, Bai L*, 2012
- Over-expression of UDP-glucose pyrophosphorylase increases validamycin A but decreases validoxylamine A production in Streptomyces hygroscopicus var. jinggangensis 5008, Zhou X, Wu H, Li Z, Zhou X, Bai L*, Deng Z, 2011
- Toward steadfast growth of antibiotic research in China: From natural products to engineered biosynthesis, Kang Q, Bai L*, Deng Z, 2011
- Overexpression of the ABC transporter AvtAB increases avermectin production in Streptomyces avermitilis, Qiu J, Zhuo Y, Zhu D, Zhou X, Zhang L, Bai L*, Deng Z, 2011
- N-methylation of the amide bond by methyltransferase asm10 in ansamitocin biosynthesis, Wu Y, Kang Q, Shen Y, Su W, Bai L*, Floss HG, 2011
- Cloning and functional analysis of the naphthomycin biosynthetic gene cluster in Streptomyces sp. CS, Wu Y, Kang Q, Shen Y, Su W, Bai L*, 2011
Awards
- 2006 Top Ten Scientific and Technological Progress in Chinese Universities
- 2007 Second Prize of Natural Science, Ministry of Education
- 2008 Second Prize of National Natural Science
