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Qian Liu
Life Science
Shanghai Jiao Tong University
Shanghai
Language: Chinese, English
Enzymes
Molecular Design
Biosynthesis
Microbial
Natural Products
Nucleases
Gene Detection
Secondary Metabolites
Metabolic Pathways
Protein Engineering
Areas of Focus
- Enzymatic mechanisms and molecular design of microbial natural product biosynthesis
- Enzymatic mechanisms and gene detection development of microbial nucleases
- Biosynthesis and targeted modification of microbial secondary metabolites
Work Experience
- 2020 - Present - Shanghai Jiao Tong University, School of Life Sciences and Biotechnology, Associate Researcher
- 2015-2019 - Shanghai Jiao Tong University, School of Life Sciences and Biotechnology, Assistant Researcher
- 2013-2015 - Wuhan University, School of Pharmacy, Postdoctoral Researcher/Assistant Researcher
Academic Background & Achievements
- 2010-2011 Exchange at UCLA, Department of Chemistry and Biomolecular Engineering
- 2007-2012 PhD in Microbiology, Shanghai Jiao Tong University
- 2003-2007 Bachelor in Biotechnology, Shanghai Jiao Tong University
- Hosted national natural science funds, key R&D plan sub-projects
Publications
- Mesophilic Argonaute-based isothermal detection of SARS-CoV-2, Qian Liu, 2022
- Argonaute-integrated isothermal amplification for rapid, portable, multiplex detection of SARS-CoV-2 and influenza viruses, Qian Liu, 2022
- Loosely-packed dynamical structures with partially-melted surface being the key for thermophilic argonaute proteins achieving high DNA-cleavage activity, Qian Liu, 2022
- Argonaute integrated single-tube PCR system enables supersensitive detection of rare mutations, Qian Liu, 2021
- Utility of B‑Factors in Protein Science: Interpreting Rigidity, Flexibility, and Internal Motion and Engineering Thermostability, Qian Liu, 2018
- The state-of-the-art strategies of protein engineering for enzyme stabilization, Qian Liu, 2018
- Argonaute with stepwise endonuclease activity promotes specific and multiplex nucleic acid detection, Qian Liu, 2021
- Probing and Engineering the Fatty Acyl Substrate Selectivity of Starter Condensation Domains of Nonribosomal Peptide Synthetases in Lipopeptide Biosynthesis, Qian Liu, 2019
- A hyperthermophilic Argonaute from Ferroglobus placidus with specificity on guide binding pattern, Qian Liu, 2021
- Characterization of protein interaction surface on fatty acyl selectivity of starter condensation domain in lipopeptide biosynthesis, Qian Liu, 2019
Awards
- 2016 Shanghai Science and Technology Young Talent Sail Plan
- 2016 Shanghai Jiao Tong University Morning Star Young Scholar Award
