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Meifeng Tao
Life Science
Shanghai Jiao Tong University
Shanghai
Language: English, Chinese
Microbial
Natural Products
Drug Discovery
Biosynthesis
Metabolic Regulation
Functional Genomics
Antibiotic Production
Gene Clusters
Compound Isolation
Biosynthetic Pathways
Areas of Focus
- Microbial natural product drug discovery, biosynthesis, and metabolic regulation
- Microbial functional genomics and chassis cell optimization for high-yield antibiotic breeding and production applications
- Efficient activation of silent natural product gene clusters; isolation and identification of new structure and activity compounds; analysis of microbial natural product biosynthetic pathways; combinatorial biosynthesis of compounds
Work Experience
- 1992-1994 - Guilin City Second Pharmaceutical Factory - Technician
- 1999-2008 - Huazhong Agricultural University, Life Science Technology College - Lecturer, Associate Professor, Doctoral Supervisor, PI at National Key Laboratory of Agricultural Microbiology
- 2005-2007 - University of Wisconsin-Madison, School of Pharmacy - Research Assistant
- 2009-2017 - Shanghai Jiao Tong University - Special Research Fellow
- 2017-present - Shanghai Jiao Tong University - Professor
Academic Background & Achievements
- 1992 Bachelor in Biochemistry, Wuhan University
- 1999 PhD in Life Science Technology, Huazhong Agricultural University
- Visiting Scholar at John Innes Centre, UK (1999-2001, 6 months each year)
Publications
- Genome-wide mutagenesis links multiple metabolic pathways with actinorhodin production in Streptomyces coelicolor, Xu Z, Li Y, Wang Y, Deng Z, Tao M, 2019
- Engineered Streptomyces lividans strains for optimal identification and expression of cryptic biosynthetic gene clusters, Peng Q, Gao G, Lü J, Long Q, Chen X, Zhang F, Xu M, Liu K, Wang Y, Deng Z, Li Z, Tao M, 2018
- Biosynthesis of tropolones in Streptomyces spp: interweaving biosynthesis and degradation of phenylacetic acid and hydroxylations on tropone ring, Chen X, Xu M, Lü J, Lin S, Deng Z, Tao M, 2018
- Formation of an angular aromatic polyketide from a linear anthrene precursor via oxidative rearrangement, Gao G, Liu X, Xu M, Jiang M, Lin S, Tao M, 2017
- Large-scale transposition mutagenesis of Streptomyces coelicolor identifies hundreds of genes influencing antibiotic biosynthesis, Xu Z, Wang Y, Chater K F, Ou HY, Xu HH, Deng Z, Tao M, 2017
- Iteratively improving natamycin production in Streptomyces gilvosporeus by a large operon-reporter based strategy, Wang Y, Tao Z, Zheng H, Zhang F, Long Q, Deng Z, Tao M, 2016
- Functional genome mining for metabolites encoded by large gene clusters through heterologous expression of a whole-genome bacterial artificial chromosome library in Streptomyces spp, Xu M, Wang Y, Zhao Z, Pang X, Deng Z, Tao M, 2016
- Hybrubins: bipyrrole tetramic acids obtained by crosstalk between a truncated undecylprodigiosin pathway and heterologous tetramic acid biosynthetic genes, Zhao Z, Shi T, Xu M, Pang X, Deng Z, Tao M, 2016
- A cellulose synthase-like protein involved in hyphal tip growth and morphological differentiation in Streptomyces, Xu H, Chater K F, Deng Z, Tao M, 2008
- A genetic and bioinformatic analysis of Streptomyces coelicolor genes containing TTA codons, possible targets for regulation by a developmentally significant tRNA, Li W, Wu J, Tao W, Zhao C, Wang Y, He X, Chandra G, Zhou X, Deng Z, Chater K F, Tao M, 2007
