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陶美凤
Life Science
上海交通大学
上海
Language: 英语, 汉语
微生物
天然产物
药物发现
生物合成
代谢调控
功能基因组学
抗生素生产
基因簇
化合物分离
生物合成途径
Areas of Focus
- 微生物天然产物药物的挖掘、生物合成及代谢调控
- 微生物功能基因组及底盘细胞优化抗生素高产育种新技术及其生产应用
- 沉默的天然产物基因簇的高效激活；新结构、新活性化合物的分离鉴定；微生物天然产物生物合成途径的解析；化合物的组合生物合成等
Work Experience
- 1992-1994 - 广西桂林市第二制药厂 - 技术员
- 1999-2008 - 华中农业大学生命科技学院 - 讲师、副教授、博导、农业微生物学国家重点实验室PI
- 2005-2007 - 美国威斯康星大学药学院 - 研究助理
- 2009-2017 - 上海交通大学 - 特别研究员
- 2017至今 - 上海交通大学 - 教授
Academic Background & Achievements
- 1992 武汉大学生物化学专业获学士学位
- 1999 华中农业大学生命科技学院获博士学位
- 1999-2001年（每年6个月）在英国约翰.英纳斯中心做访问学者
Publications
- Genome-wide mutagenesis links multiple metabolic pathways with actinorhodin production in Streptomyces coelicolor, Xu Z, Li Y, Wang Y, Deng Z, Tao M, 2019
- Engineered Streptomyces lividans strains for optimal identification and expression of cryptic biosynthetic gene clusters, Peng Q, Gao G, Lü J, Long Q, Chen X, Zhang F, Xu M, Liu K, Wang Y, Deng Z, Li Z, Tao M, 2018
- Biosynthesis of tropolones in Streptomyces spp: interweaving biosynthesis and degradation of phenylacetic acid and hydroxylations on tropone ring, Chen X, Xu M, Lü J, Lin S, Deng Z, Tao M, 2018
- Formation of an angular aromatic polyketide from a linear anthrene precursor via oxidative rearrangement, Gao G, Liu X, Xu M, Jiang M, Lin S, Tao M, 2017
- Large-scale transposition mutagenesis of Streptomyces coelicolor identifies hundreds of genes influencing antibiotic biosynthesis, Xu Z, Wang Y, Chater K F, Ou HY, Xu HH, Deng Z, Tao M, 2017
- Iteratively improving natamycin production in Streptomyces gilvosporeus by a large operon-reporter based strategy, Wang Y, Tao Z, Zheng H, Zhang F, Long Q, Deng Z, Tao M, 2016
- Functional genome mining for metabolites encoded by large gene clusters through heterologous expression of a whole-genome bacterial artificial chromosome library in Streptomyces spp, Xu M, Wang Y, Zhao Z, Pang X, Deng Z, Tao M, 2016
- Hybrubins: bipyrrole tetramic acids obtained by crosstalk between a truncated undecylprodigiosin pathway and heterologous tetramic acid biosynthetic genes, Zhao Z, Shi T, Xu M, Pang X, Deng Z, Tao M, 2016
- A cellulose synthase-like protein involved in hyphal tip growth and morphological differentiation in Streptomyces, Xu H, Chater K F, Deng Z, Tao M, 2008
- A genetic and bioinformatic analysis of Streptomyces coelicolor genes containing TTA codons, possible targets for regulation by a developmentally significant tRNA, Li W, Wu J, Tao W, Zhao C, Wang Y, He X, Chandra G, Zhou X, Deng Z, Chater K F, Tao M, 2007
