Professor | Hongwei Wang | Asia Growth Partners

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Name	Hongwei Wang
Contact Information	hongweiwang@tsinghua.edu.cn
Language ability	English, Chinese
Province	Beijing

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Name

Hongwei Wang

Contact Information

hongweiwang@tsinghua.edu.cn

Language ability

English, Chinese

Province

Beijing

University/Lab Affiliation and Title	Tsinghua University
Faculty	Life Sciences
Academic Background & Achievements	1992-1996 Bachelor: Department of Biological Sciences and Technology, Tsinghua University 1996-2001 PhD: Department of Biological Sciences and Technology, Tsinghua University Dean of the School of Life Sciences, Tsinghua University (2016.04-2021.04)
Work Experience	2001-2006 - Lawrence Berkeley National Laboratory, Life Sciences Division - Postdoctoral Researcher 2006-2008 - Lawrence Berkeley National Laboratory, Life Sciences Division - Research Scientist 2009-2011 - Yale University, Department of Molecular Biophysics and Biochemistry - Tenure-Track Assistant Professor 2010.12-present - Tsinghua University, School of Life Sciences - Professor, Doctoral Supervisor

University/Lab Affiliation and Title

Tsinghua University

Faculty

Life Sciences

Academic Background & Achievements

1992-1996 Bachelor: Department of Biological Sciences and Technology, Tsinghua University
1996-2001 PhD: Department of Biological Sciences and Technology, Tsinghua University
Dean of the School of Life Sciences, Tsinghua University (2016.04-2021.04)

Work Experience

2001-2006 - Lawrence Berkeley National Laboratory, Life Sciences Division - Postdoctoral Researcher
2006-2008 - Lawrence Berkeley National Laboratory, Life Sciences Division - Research Scientist
2009-2011 - Yale University, Department of Molecular Biophysics and Biochemistry - Tenure-Track Assistant Professor
2010.12-present - Tsinghua University, School of Life Sciences - Professor, Doctoral Supervisor

Areas of Focus	Development of more efficient and higher resolution cryo-EM methodologies Molecular mechanisms and regulation of nucleic acid quality control Coordination mechanisms of cytoskeleton and biomembrane systems
Publications	Structural insights into the mechanism of GTP initiation of microtubule assembly, Zhou J, Wang A, Song Y, Liu N, Wang J, Li Y, Liang X, Li GH, Chu HY, Wang HW, 2023 Dual-Affinity Graphene Sheets for High-Resolution Cryo-Electron Microscopy, Cheng H, Zheng LM, Liu N, Huang CY, Xu J, Lu Y, Cui XY, Xu K, Hou Y, Tang JC, Zhang Z, Li J, Ni XD, Chen YN, Peng HL, Wang HW, 2023 In situ structure of the red algal phycobilisome–PSII–PSI–LHC megacomplex, You X, Zhang X, Cheng J, Xiao YN, Ma JF, Sun S, Zhang XZ, Wang HW, Sui SF, 2023 Uniform thin ice on ultraflat graphene for high-resolution cryo-EM, Zheng LM, Liu N, Gao XY, Zhu WQ, Liu K, Wu C, Yan R, Zhang JC, Gao X, Yao YT, Deng B, Xu J, Lu Y, Liu, ZM, Li MS, Wei XD, Wang HW, Peng HL, 2023 Functionalized graphene grids with various charges for single-particle cryo-EM, Lu Y, Liu N, Liu Y, Zheng LM, Yang JH, Wang J, Jia X, Zi QR, Peng HL, Rao Y, Wang HW, 2022 Structural insights into dsRNA processing by Drosophila Dicer-2-Loqs-PD, Su S, Wang J, Deng T, Yuan X, He J, Liu N, Li XM, Huang Y, Wang HW, Ma JB, 2022 Atomically Thin Bilayer Janus Membranes for Cryo-electron Microscopy, Zheng L, Liu N, Liu Y, Li N, Zhang J, Wang C, Zhu W, Chen Y, Ying D, Xu J, Yang Z, Gao X, Tang J, Wang X, Liang Z, Zou R, Li Y, Gao P, Wei X, Wang HW, Peng HL, 2021 Reduced graphene oxide membrane as supporting film for high-resolution cryo-EM, Liu N, Zheng LM, Xu J, Wang J, Hu CX, Lan J, Zhang X, Zhang J, Xu K, Cheng H, Yang Z, Gao X, Wang X, Peng HL, Chen YN, Wang HW, 2021 Structural Basis for pri-miRNA Recognition by Drosha, Jin W, Wang J, Liu CP, Wang HW, Xu RM, 2020 Robust ultraclean atomically thin membranes for atomic-resolution electron microscopy, Zheng L, Chen Y, Li N, Zhang J, Liu N, Liu J, Dang W, Deng B, Li Y, Gao X, Tan C, Yang Z, Xu S, Wang M, Yang H, Sun L, Cui Y, Wei X, Gao P, Wang HW, Peng H, 2020 Single particle cryo-EM reconstruction of 52 kDa streptavidin at 3.2 Angstrom resolution, Fan X, Wang J, Zhang X, Yang Z, Zhang JC, Zhao L, Peng HL, Lei J, Wang HW, 2019 Bioactive Functionalized Monolayer Graphene for High-Resolution Cryo-Electron Microscopy, Liu N, Zhang J, Chen Y, Liu C, Zhang X, Xu K, Wen J, Luo Z, Chen S, Gao P, Jia K, Liu Z, Peng H, Wang HW, 2019 Ligand-triggered allosteric ADP release primes a plant NLR complex, Wang J, Wang J, Hu M, Wu S, Qi J, Wang G, Han Z, Qi Y, Gao N, Wang HW, Zhou JM, Chai J, 2019 Reconstitution and structure of a plant NLR resistosome conferring immunity, Wang J, Hu M, Wang J, Qi J, Han Z, Wang G, Qi Y, Wang HW, Zhou JM, Chai J, 2019 Cryo-EM Structure of Human Dicer and Its Complexes with a Pre-miRNA Substrate, Liu Z, Wang J, Cheng H, Ke X, Sun L, Zhang Q, Wang HW, 2018

Areas of Focus

Development of more efficient and higher resolution cryo-EM methodologies
Molecular mechanisms and regulation of nucleic acid quality control
Coordination mechanisms of cytoskeleton and biomembrane systems

Publications

Structural insights into the mechanism of GTP initiation of microtubule assembly, Zhou J, Wang A, Song Y, Liu N, Wang J, Li Y, Liang X, Li GH, Chu HY, Wang HW*, 2023
Dual-Affinity Graphene Sheets for High-Resolution Cryo-Electron Microscopy, Cheng H, Zheng LM, Liu N, Huang CY, Xu J, Lu Y, Cui XY, Xu K, Hou Y, Tang JC, Zhang Z, Li J, Ni XD, Chen YN*, Peng HL*, Wang HW*, 2023
In situ structure of the red algal phycobilisome–PSII–PSI–LHC megacomplex, You X, Zhang X, Cheng J, Xiao YN, Ma JF, Sun S, Zhang XZ*, Wang HW*, Sui SF*, 2023
Uniform thin ice on ultraflat graphene for high-resolution cryo-EM, Zheng LM, Liu N*, Gao XY, Zhu WQ, Liu K, Wu C, Yan R, Zhang JC, Gao X, Yao YT, Deng B, Xu J, Lu Y, Liu, ZM, Li MS, Wei XD*, Wang HW*, Peng HL*, 2023
Functionalized graphene grids with various charges for single-particle cryo-EM, Lu Y, Liu N*, Liu Y, Zheng LM, Yang JH, Wang J, Jia X, Zi QR, Peng HL*, Rao Y*, Wang HW*, 2022
Structural insights into dsRNA processing by Drosophila Dicer-2-Loqs-PD, Su S, Wang J, Deng T, Yuan X, He J, Liu N, Li XM, Huang Y, Wang HW*, Ma JB*, 2022
Atomically Thin Bilayer Janus Membranes for Cryo-electron Microscopy, Zheng L, Liu N, Liu Y, Li N, Zhang J, Wang C, Zhu W, Chen Y, Ying D, Xu J, Yang Z, Gao X, Tang J, Wang X, Liang Z, Zou R, Li Y, Gao P, Wei X*, Wang HW*, Peng HL*, 2021
Reduced graphene oxide membrane as supporting film for high-resolution cryo-EM, Liu N, Zheng LM, Xu J, Wang J, Hu CX, Lan J, Zhang X, Zhang J, Xu K, Cheng H, Yang Z, Gao X, Wang X, Peng HL*, Chen YN*, Wang HW*, 2021
Structural Basis for pri-miRNA Recognition by Drosha, Jin W, Wang J, Liu CP, Wang HW*, Xu RM*, 2020
Robust ultraclean atomically thin membranes for atomic-resolution electron microscopy, Zheng L, Chen Y, Li N, Zhang J, Liu N, Liu J, Dang W, Deng B, Li Y, Gao X, Tan C, Yang Z, Xu S, Wang M, Yang H, Sun L, Cui Y, Wei X, Gao P*, Wang HW*, Peng H*, 2020
Single particle cryo-EM reconstruction of 52 kDa streptavidin at 3.2 Angstrom resolution, Fan X, Wang J, Zhang X, Yang Z, Zhang JC, Zhao L, Peng HL, Lei J*, Wang HW*, 2019
Bioactive Functionalized Monolayer Graphene for High-Resolution Cryo-Electron Microscopy, Liu N, Zhang J, Chen Y*, Liu C, Zhang X, Xu K, Wen J, Luo Z, Chen S, Gao P, Jia K, Liu Z, Peng H*, Wang HW*, 2019
Ligand-triggered allosteric ADP release primes a plant NLR complex, Wang J, Wang J, Hu M, Wu S, Qi J, Wang G, Han Z, Qi Y, Gao N, Wang HW*, Zhou JM*, Chai J*, 2019
Reconstitution and structure of a plant NLR resistosome conferring immunity, Wang J, Hu M, Wang J, Qi J, Han Z, Wang G, Qi Y, Wang HW*, Zhou JM*, Chai J*, 2019
Cryo-EM Structure of Human Dicer and Its Complexes with a Pre-miRNA Substrate, Liu Z, Wang J, Cheng H, Ke X, Sun L, Zhang Q, Wang HW*, 2018

Cryo-Em Methodology Efficiency Resolution Nucleic Acids Quality Control Molecular Mechanisms Regulation Cytoskeleton Biomembranes

Hongwei Wang - Tsinghua University

Mao-Fu Liao - Southern University of Science and Technology

Fengfeng Niu - Southern University of Science and Technology

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