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Jiamin Zhang
Life Science
Tongji University
Shanghai
Language: Chinese, English
Genomic Stability
Epigenetics
Cancer Therapy
Chromatin
Molecular Mechanisms
Telomere Maintenance
Dna Damage Repair
Deep Learning
Multi-Omics
Gene Regulation Networks
Areas of Focus
- Genomic stability mechanisms and epigenetic testing new technologies
- Development of new strategies for targeted cancer therapy
Work Experience
- 2015-2020 - Massachusetts General Hospital Cancer Center/Harvard Medical School, Postdoctoral Work
- 2021 - Tongji University Affiliated Tongji Hospital, Employed
- 2021 - School of Life Sciences and Technology, Tongji University, Employed
Academic Background & Achievements
- 2008 - Bachelor of Agriculture: China Agricultural University
- 2013 - PhD in Science: Peking Union Medical College/Beijing Institute of Life Sciences
- 2021 - National Natural Science Foundation of China Outstanding Youth Science Fund Project (Overseas)
Publications
- Protocol to Stimulate and Delineate Alternative Lengthening of Telomeres (ALT) in Human U2OS Cells, Zhang, J.M., Zou, L., 2022
- RNA transcripts stimulate homologous recombination by forming DR-loops, Ouyang, J., Yadav, T., Zhang, J.M., Yang, H., Rheinbay, E., Guo, H., Haber, D.A., Lan, L., Zou, L., 2021
- Alternative lengthening of telomeres is a self-perpetuating process in ALT-associated PML bodies, Zhang, J.M., Genois, M.M., Ouyang, J., Lan, L., Zou, L., 2021
- Alternative Lengthening of Telomeres through Two Distinct Break-Induced Replication Pathways, Zhang, J.M., Yadav, T., Ouyang, J., Lan, L., Zou, L., 2019
- cGAS suppresses genomic instability as a decelerator of replication forks, Chen, H., Chen, H., Zhang, J.M., Wang, Y., Simoneau, A., Yang, H., Levine, A.S., Zou, L., Chen, Z., Lan L., 2020
- Synthetic lethality by targeting the RUVBL1/2-TTT complex in mTORC1-hyperactive cancer cells, Shin, S.H., Lee, J.S., Zhang, J.M., Choi, S., Boskovic, Z.V., Zhao, R., Song, M., Wang, R., Tian, J., Lee, M.H., et al., 2020
- CRL4Cdt2 ubiquitin ligase regulates Dna2 and Rad16 (XPF) nucleases by targeting Pxd1 for degradation, Zhang, J.M., Zheng, J.X., Ding, Y.H., Zhang, X.R., Suo, F., Ren, J.Y., Dong, M.Q., Du, L.L., 2020
- Alternative lengthening of telomeres: from molecular mechanisms to therapeutic outlooks, Zhang, J.M., and Zou, L., 2020
- ATR protects the genome against R loops through a MUS81-triggered feedback loop, Matos, D.A., Zhang, J.M., Ouyang, J., Nguyen, H.D., Genois, M.M. and Zou, L., 2020
- Fission yeast Pxd1 promotes proper DNA repair by activating Rad16XPF and inhibiting Dna2, Zhang, J.M., Liu, X.M., Ding, Y.H., Xiong, L.Y., Ren, J.Y., Zhou, Z.X., Wang, H.T., Zhang, M.J., Yu, Y., Dong, M.Q., et al., 2014
