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张家民
Life Science
同济大学
上海
Language: 中文, 英语
基因组稳定性
表观遗传学
癌症治疗
染色质
分子机制
端粒维护
Dna损伤修复
深度学习
多组学
基因调控网络
Areas of Focus
- 基因组稳定性机制和表观遗传检测新技术
- 开发针对癌症的靶向治疗新策略
Work Experience
- 2015-2020年 - 麻省总医院癌症中心/哈佛医学院，博士后工作
- 2021年 - 同济大学附属同济医院，受聘
- 2021年 - 同济大学生命科学与技术学院，受聘
Academic Background & Achievements
- 2008年 - 农学学士：中国农业大学
- 2013年 - 理学博士：北京协和医学院/北京生命科学研究所
- 2021年 - 国家自然科学基金优秀青年科学基金项目（海外）
Publications
- Protocol to Stimulate and Delineate Alternative Lengthening of Telomeres (ALT) in Human U2OS Cells, Zhang, J.M., Zou, L., 2022
- RNA transcripts stimulate homologous recombination by forming DR-loops, Ouyang, J., Yadav, T., Zhang, J.M., Yang, H., Rheinbay, E., Guo, H., Haber, D.A., Lan, L., Zou, L., 2021
- Alternative lengthening of telomeres is a self-perpetuating process in ALT-associated PML bodies, Zhang, J.M., Genois, M.M., Ouyang, J., Lan, L., Zou, L., 2021
- Alternative Lengthening of Telomeres through Two Distinct Break-Induced Replication Pathways, Zhang, J.M., Yadav, T., Ouyang, J., Lan, L., Zou, L., 2019
- cGAS suppresses genomic instability as a decelerator of replication forks, Chen, H., Chen, H., Zhang, J.M., Wang, Y., Simoneau, A., Yang, H., Levine, A.S., Zou, L., Chen, Z., Lan L., 2020
- Synthetic lethality by targeting the RUVBL1/2-TTT complex in mTORC1-hyperactive cancer cells, Shin, S.H., Lee, J.S., Zhang, J.M., Choi, S., Boskovic, Z.V., Zhao, R., Song, M., Wang, R., Tian, J., Lee, M.H., et al., 2020
- CRL4Cdt2 ubiquitin ligase regulates Dna2 and Rad16 (XPF) nucleases by targeting Pxd1 for degradation, Zhang, J.M., Zheng, J.X., Ding, Y.H., Zhang, X.R., Suo, F., Ren, J.Y., Dong, M.Q., Du, L.L., 2020
- Alternative lengthening of telomeres: from molecular mechanisms to therapeutic outlooks, Zhang, J.M., and Zou, L., 2020
- ATR protects the genome against R loops through a MUS81-triggered feedback loop, Matos, D.A., Zhang, J.M., Ouyang, J., Nguyen, H.D., Genois, M.M. and Zou, L., 2020
- Fission yeast Pxd1 promotes proper DNA repair by activating Rad16XPF and inhibiting Dna2, Zhang, J.M., Liu, X.M., Ding, Y.H., Xiong, L.Y., Ren, J.Y., Zhou, Z.X., Wang, H.T., Zhang, M.J., Yu, Y., Dong, M.Q., et al., 2014
