Professor | Xuechuan Hong | Asia Growth Partners

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Name	Xuechuan Hong
Contact Information	Xhy78@whu.edu.cn
Language ability	English, Chinese
Province	Hubei

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Name

Xuechuan Hong

Contact Information

Xhy78@whu.edu.cn

Language ability

English, Chinese

Province

Hubei

University/Lab Affiliation and Title	Wuhan University
Faculty	Medical School
Academic Background & Achievements	2001.01–2005.07 PhD in Chemistry, University of Missouri, Columbia 1997.09–1999.11 Master's in Chemical Engineering, Tianjin University 1993.09–1997.07 Bachelor's in Applied Chemistry, Tianjin University 1993.09–1997.07 Bachelor's in Technical Economics, Tianjin University
Work Experience	2017.12 – Present Professor and Doctoral Supervisor, Medical School, Tibet University 2010.10 – Present Professor and Doctoral Supervisor, School of Pharmaceutical Sciences, Wuhan University 2007.10–2010.10 Senior Researcher, AMRI, USA 2005.09–2007.09 Postdoctoral Research Fellow, Department of Chemistry, Emory University, USA 1999.12–2000.07 Research Trainee, School of Pharmacy, Hokkaido University, Japan
Awards	2018 Outstanding Worker of Tibet University 2017-2018 Outstanding Paper Contribution Award, Medical School, Tibet University 2016 Zhu Yubi Medical Award, Wuhan University 2016 Luojia Scholar Distinguished Professor, Wuhan University 2016 Medical Outstanding Contribution Award, Medical Department, Wuhan University 2015 Medical Outstanding Contribution Award, Medical Department, Wuhan University 2014 Third Batch 'Yellow Crane Talent' Plan, Wuhan 2014 Best Presentation Award, 9th World Chinese Pharmaceutical Conference, American Chemical Society

University/Lab Affiliation and Title

Wuhan University

Faculty

Medical School

Academic Background & Achievements

2001.01–2005.07 PhD in Chemistry, University of Missouri, Columbia
1997.09–1999.11 Master's in Chemical Engineering, Tianjin University
1993.09–1997.07 Bachelor's in Applied Chemistry, Tianjin University
1993.09–1997.07 Bachelor's in Technical Economics, Tianjin University

Work Experience

2017.12 – Present Professor and Doctoral Supervisor, Medical School, Tibet University
2010.10 – Present Professor and Doctoral Supervisor, School of Pharmaceutical Sciences, Wuhan University
2007.10–2010.10 Senior Researcher, AMRI, USA
2005.09–2007.09 Postdoctoral Research Fellow, Department of Chemistry, Emory University, USA
1999.12–2000.07 Research Trainee, School of Pharmacy, Hokkaido University, Japan

Awards

2018 Outstanding Worker of Tibet University
2017-2018 Outstanding Paper Contribution Award, Medical School, Tibet University
2016 Zhu Yubi Medical Award, Wuhan University
2016 Luojia Scholar Distinguished Professor, Wuhan University
2016 Medical Outstanding Contribution Award, Medical Department, Wuhan University
2015 Medical Outstanding Contribution Award, Medical Department, Wuhan University
2014 Third Batch 'Yellow Crane Talent' Plan, Wuhan
2014 Best Presentation Award, 9th World Chinese Pharmaceutical Conference, American Chemical Society

Areas of Focus	Manufacture of organic small molecule probes in the second near-infrared region, visualization of tumor and viral infection mechanisms, and drug development
Publications	Polymethine thiopyrylium fluorophores with absorption beyond 1000 nm for biological imaging in the second near-infrared sub-window, Xuechuan Hong, 2019 Pyrazolopyrimidines as potent stimulators for transient receptor potential canonical 3/6/7 channels, Xuechuan Hong, 2017 A small molecule dye for NIR II imaging, Xuechuan Hong, 2016 Strained Cyclooctyne as a Molecular Platform for Construction of Multimodal Imaging Probes, Xuechuan Hong, 2015 A high quantum yield molecule-protein complex fluorophore for near-infrared II imaging, Xuechuan Hong, 2017 Dual-function near-infrared II fluorescence and PET probe for tumor delineation and image-guided surgery, Xuechuan Hong, 2018 Novel near-Infrared II aggregation-induced emission dots for in vivo bioimaging, Xuechuan Hong, 2019 Novel bright-emission small-molecule NIR-II fluorophores for in vivo tumor imaging and image-guided surgery, Xuechuan Hong, 2017 Novel benzo-bis(1,2,5-thiadiazole) fluorophores for in vivo NIR-II imaging of cancer, Xuechuan Hong, 2016 Recyclable Cu(I)/Melanin dots for cycloadditions, bioconjugation and cell labeling, Xuechuan Hong, 2016 Metal-free direct amidation of peptidyl thiol esters with amino acid esters, Xuechuan Hong, 2011 Quaternary ammonium salt based NIR-II probes for In vivo imaging, Xuechuan Hong, 2019 Mn-loaded apolactoferrin dots for in vivo MRI and NIR-II cancer imaging, Xuechuan Hong, 2019 Identification and optimization of 2-aminobenzimidazole derivatives as novel inhibitors of TRPC4 and TRPC5 channels, Xuechuan Hong, 2015 Pyrazolo[1,5-a]pyrimidine TRPC6 antagonists for the treatment of gastric cancer, Xuechuan Hong, 2018 Near-Infrared II dye-protein complex for biomedical imaging and imaging-guided photothermal therapy, Xuechuan Hong, 2018 A novel near-infrared fluorescent light-up probe for tumor imaging and drug-induced liver injury detection, Xuechuan Hong, 2019 New glowing dyes in vivo imaging with wavelengths beyond 1500 nm, Xuechuan Hong, 2019 Design, synthesis and pharmacological evaluation of novel N-(2-(1,1-dimethyl-5, 7-dioxo-4, 6-diazaspiro[2.4]heptan-6-yl)ethyl) sulfonamide derivatives as potential anticonvulsant agents, Xuechuan Hong, 2015 Design and synthesis of 6-oxo-1,4,5,6-tetrahydropyrimidine-5-carboxylate derivatives as neuraminidase inhibitors, Xuechuan Hong, 2014

Areas of Focus

Manufacture of organic small molecule probes in the second near-infrared region, visualization of tumor and viral infection mechanisms, and drug development

Publications

Polymethine thiopyrylium fluorophores with absorption beyond 1000 nm for biological imaging in the second near-infrared sub-window, Xuechuan Hong*, 2019
Pyrazolopyrimidines as potent stimulators for transient receptor potential canonical 3/6/7 channels, Xuechuan Hong*, 2017
A small molecule dye for NIR II imaging, Xuechuan Hong*, 2016
Strained Cyclooctyne as a Molecular Platform for Construction of Multimodal Imaging Probes, Xuechuan Hong*, 2015
A high quantum yield molecule-protein complex fluorophore for near-infrared II imaging, Xuechuan Hong*, 2017
Dual-function near-infrared II fluorescence and PET probe for tumor delineation and image-guided surgery, Xuechuan Hong*, 2018
Novel near-Infrared II aggregation-induced emission dots for in vivo bioimaging, Xuechuan Hong*, 2019
Novel bright-emission small-molecule NIR-II fluorophores for in vivo tumor imaging and image-guided surgery, Xuechuan Hong*, 2017
Novel benzo-bis(1,2,5-thiadiazole) fluorophores for in vivo NIR-II imaging of cancer, Xuechuan Hong*, 2016
Recyclable Cu(I)/Melanin dots for cycloadditions, bioconjugation and cell labeling, Xuechuan Hong*, 2016
Metal-free direct amidation of peptidyl thiol esters with amino acid esters, Xuechuan Hong*, 2011
Quaternary ammonium salt based NIR-II probes for In vivo imaging, Xuechuan Hong*, 2019
Mn-loaded apolactoferrin dots for in vivo MRI and NIR-II cancer imaging, Xuechuan Hong*, 2019
Identification and optimization of 2-aminobenzimidazole derivatives as novel inhibitors of TRPC4 and TRPC5 channels, Xuechuan Hong*, 2015
Pyrazolo[1,5-a]pyrimidine TRPC6 antagonists for the treatment of gastric cancer, Xuechuan Hong*, 2018
Near-Infrared II dye-protein complex for biomedical imaging and imaging-guided photothermal therapy, Xuechuan Hong*, 2018
A novel near-infrared fluorescent light-up probe for tumor imaging and drug-induced liver injury detection, Xuechuan Hong*, 2019
New glowing dyes in vivo imaging with wavelengths beyond 1500 nm, Xuechuan Hong*, 2019
Design, synthesis and pharmacological evaluation of novel N-(2-(1,1-dimethyl-5, 7-dioxo-4, 6-diazaspiro[2.4]heptan-6-yl)ethyl) sulfonamide derivatives as potential anticonvulsant agents, Xuechuan Hong*, 2015
Design and synthesis of 6-oxo-1,4,5,6-tetrahydropyrimidine-5-carboxylate derivatives as neuraminidase inhibitors, Xuechuan Hong*, 2014

Nir-Ii Probes Organic Molecules Small Molecules Tumor Visualization Viral Mechanisms Drug Development Molecular Imaging Biomedical Imaging Cancer Research Therapeutic Agents

Lihong Bu - Wuhan University

Hao Chen - University of Chinese Academy of Sciences

Rui-Min Huang - University of Chinese Academy of Sciences

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