Xianjiang Lan

xianjiang_lan@fudan.edu.cn

English, Chinese

Shanghai

Fudan University

Basic Medical Sciences

• 2011.09—2016.07 Ph.D. in Epigenetics and Molecular Carcinogenesis: University of Texas Health Science Center at Houston & MD Anderson Cancer Center
• 2008.09—2011.07 Master's in Genetics: Sun Yat-sen University
• 2004.09—2008.07 Bachelor's in Biotechnology: South-Central University for Nationalities

• 2021.08—Present - Fudan University - Junior Researcher
• 2016.10—2021.08 - Children's Hospital of Philadelphia - Postdoctoral Researcher

• 2020: Outstanding Abstract Achievement Award, American Society of Hematology Annual Meeting
• 2018: Excellent Abstract Achievement Award, American Society of Hematology Annual Meeting

Comprehensive analysis of hemoglobin gene expression regulation mechanisms using high-throughput CRISPR library screening technology, biochemistry, multi-omics, high-throughput sequencing, and bioinformatics to identify new targets with therapeutic potential for thalassemia, and collaboration to develop and test small molecule inhibitors with therapeutic potential for thalassemia.
Analysis of the function of the extremely specific transcription factor ZNF410 in development and disease.
Promotion of the application of high-throughput CRISPR library screening technology in disease models such as liver cancer drug resistance to find new targets.

• ZNF410 Uniquely Activates the NuRD Component CHD4 to Silence Fetal Hemoglobin Expression, Lan, X., Ren, R., Feng, R., Ly, L.C., Lan, Y., Zhang, Z., Aboreden, N., Qin, K., Horton, J.R., Grevet, J.D., et al., 2021
• HRI depletion cooperates with pharmacologic inducers to elevate fetal hemoglobin and reduce sickle cell formation, Peslak SA, Khandros E, Huang P, Lan X, Geronimo CL, Grevet JD, Abdulmalik O, Zhang Z, Giardine BM, Keller CA, Shi J, Hardison RC, Blobel GA., 2020
• The HRI-regulated transcription factor ATF4 activates BCL11A transcription to silence fetal hemoglobin expression, Huang P, Peslak SA, Lan X, Khandros E, Yano JA, Sharma M, Keller CA, Giardine B, Qin K, Abdulmalik O, Hardison RC, Shi J, Blobel GA., 2020
• The E3 ligase adaptor molecule SPOP regulates fetal hemoglobin levels in adult erythroid cells, Lan X, Khandros E, Huang P, Peslak SA, Bhardwaj SK, Grevet JD, Abdulmalik O, Wang H, Keller CA, Giardine B, Baeza J, Duffner ER, El Demerdash O, Wu XS, Vakoc CR, Garcia BA, Hardison RC, Shi J, Blobel GA., 2019
• Domain-focused CRISPR screen identifies HRI as a fetal hemoglobin regulator in human erythroid cells, Grevet JD*, Lan X* Hamagami N, Edwards CR, Sankaranarayanan L, Ji X, Bhardwaj SK, Face CJ, Posocco DF, Abdulmalik O, Keller CA, Giardine B, Sidoli S, Garcia BA, Chou ST, Liebhaber SA, Hardison RC, Shi J, Blobel GA., 2018
• USP44 Is an Integral Component of N-CoR that Contributes to Gene Repression by Deubiquitinating Histone H2B, Lan X, Atanassov BS, Li W, Zhang Y, Florens L, Mohan RD, Galardy PJ, Washburn MP, Workman JL, Dent SYR., 2016
• Cytoplasmic ATXN7L3B Interferes with Nuclear Functions of the SAGA Deubiquitinase Module, Li W, Atanassov BS, Lan X, Mohan RD, Swanson SK, Farria AT, Florens L, Washburn MP, Workman JL, Dent SY., 2016
• ATXN7L3 and ENY2 Coordinate Activity of Multiple H2B Deubiquitinases Important for Cellular Proliferation and Tumor Growth, Atanassov BS, Mohan RD, Lan X, Kuang X, Lu Y, Lin K, McIvor E, Li W, Zhang Y, Florens L, Byrum SD, Mackintosh SG, Calhoun-Davis T, Koutelou E, Wang L, Tang DG, Tackett AJ, Washburn MP, Workman JL, Dent SY., 2016
• Poly(Q) Expansions in ATXN7 Affect Solubility but Not Activity of the SAGA Deubiquitinating Module, Lan X*, Koutelou E*, Schibler AC, Chen YC, Grant PA, Dent SY., 2015