Professor | 蓝贤江 | 数字化转型顾问

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Name	蓝贤江
Contact Information	xianjiang_lan@fudan.edu.cn
Language ability	英语, 中文
Province	上海

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Name

蓝贤江

Contact Information

xianjiang_lan@fudan.edu.cn

Language ability

英语, 中文

Province

上海

University/Lab Affiliation and Title	复旦大学
Faculty	Basic Medical Sciences
Academic Background & Achievements	2011.09—2016.07 表观遗传学和分子肿瘤发生博士: 美国德克萨斯大学休斯敦健康科学中心&MD安德森癌症中心 2008.09—2011.07 遗传学硕士: 中山大学 2004.09—2008.07 生物技术学士: 中南民族大学
Work Experience	2021.08—至今 - 复旦大学 - 青年研究员 2016.10—2021.08 - 美国费城儿童医院 - 博士后
Awards	2020: 杰出摘要成就奖, 美国血液学年会 2018: 优秀摘要成就奖, 美国血液学年会

University/Lab Affiliation and Title

复旦大学

Faculty

Basic Medical Sciences

Academic Background & Achievements

2011.09—2016.07 表观遗传学和分子肿瘤发生博士: 美国德克萨斯大学休斯敦健康科学中心&MD安德森癌症中心
2008.09—2011.07 遗传学硕士: 中山大学
2004.09—2008.07 生物技术学士: 中南民族大学

Work Experience

2021.08—至今 - 复旦大学 - 青年研究员
2016.10—2021.08 - 美国费城儿童医院 - 博士后

Awards

2020: 杰出摘要成就奖, 美国血液学年会
2018: 优秀摘要成就奖, 美国血液学年会

Areas of Focus	结合高通量CRISPR文库筛选技术，生物化学，多组学，高通量测序，生物信息学等全面解析血红蛋白基因表达调控机制，鉴定具有治疗地中海贫血症潜能的新靶点，合作开发和测试具有治疗地中海贫血症潜能的小分子抑制剂。解析极端特异转录因子ZNF410在发育和疾病中的功能。推广高通量分类CRISPR文库筛选技术在肝癌耐药等疾病模型中的应用，寻找新靶点。
Publications	ZNF410 Uniquely Activates the NuRD Component CHD4 to Silence Fetal Hemoglobin Expression, Lan, X., Ren, R., Feng, R., Ly, L.C., Lan, Y., Zhang, Z., Aboreden, N., Qin, K., Horton, J.R., Grevet, J.D., et al., 2021 HRI depletion cooperates with pharmacologic inducers to elevate fetal hemoglobin and reduce sickle cell formation, Peslak SA, Khandros E, Huang P, Lan X, Geronimo CL, Grevet JD, Abdulmalik O, Zhang Z, Giardine BM, Keller CA, Shi J, Hardison RC, Blobel GA., 2020 The HRI-regulated transcription factor ATF4 activates BCL11A transcription to silence fetal hemoglobin expression, Huang P, Peslak SA, Lan X, Khandros E, Yano JA, Sharma M, Keller CA, Giardine B, Qin K, Abdulmalik O, Hardison RC, Shi J, Blobel GA., 2020 The E3 ligase adaptor molecule SPOP regulates fetal hemoglobin levels in adult erythroid cells, Lan X, Khandros E, Huang P, Peslak SA, Bhardwaj SK, Grevet JD, Abdulmalik O, Wang H, Keller CA, Giardine B, Baeza J, Duffner ER, El Demerdash O, Wu XS, Vakoc CR, Garcia BA, Hardison RC, Shi J, Blobel GA., 2019 Domain-focused CRISPR screen identifies HRI as a fetal hemoglobin regulator in human erythroid cells, Grevet JD, Lan X Hamagami N, Edwards CR, Sankaranarayanan L, Ji X, Bhardwaj SK, Face CJ, Posocco DF, Abdulmalik O, Keller CA, Giardine B, Sidoli S, Garcia BA, Chou ST, Liebhaber SA, Hardison RC, Shi J, Blobel GA., 2018 USP44 Is an Integral Component of N-CoR that Contributes to Gene Repression by Deubiquitinating Histone H2B, Lan X, Atanassov BS, Li W, Zhang Y, Florens L, Mohan RD, Galardy PJ, Washburn MP, Workman JL, Dent SYR., 2016 Cytoplasmic ATXN7L3B Interferes with Nuclear Functions of the SAGA Deubiquitinase Module, Li W, Atanassov BS, Lan X, Mohan RD, Swanson SK, Farria AT, Florens L, Washburn MP, Workman JL, Dent SY., 2016 ATXN7L3 and ENY2 Coordinate Activity of Multiple H2B Deubiquitinases Important for Cellular Proliferation and Tumor Growth, Atanassov BS, Mohan RD, Lan X, Kuang X, Lu Y, Lin K, McIvor E, Li W, Zhang Y, Florens L, Byrum SD, Mackintosh SG, Calhoun-Davis T, Koutelou E, Wang L, Tang DG, Tackett AJ, Washburn MP, Workman JL, Dent SY., 2016 Poly(Q) Expansions in ATXN7 Affect Solubility but Not Activity of the SAGA Deubiquitinating Module, Lan X, Koutelou E, Schibler AC, Chen YC, Grant PA, Dent SY., 2015

Areas of Focus

结合高通量CRISPR文库筛选技术，生物化学，多组学，高通量测序，生物信息学等全面解析血红蛋白基因表达调控机制，鉴定具有治疗地中海贫血症潜能的新靶点，合作开发和测试具有治疗地中海贫血症潜能的小分子抑制剂。
解析极端特异转录因子ZNF410在发育和疾病中的功能。
推广高通量分类CRISPR文库筛选技术在肝癌耐药等疾病模型中的应用，寻找新靶点。

Publications

ZNF410 Uniquely Activates the NuRD Component CHD4 to Silence Fetal Hemoglobin Expression, Lan, X., Ren, R., Feng, R., Ly, L.C., Lan, Y., Zhang, Z., Aboreden, N., Qin, K., Horton, J.R., Grevet, J.D., et al., 2021
HRI depletion cooperates with pharmacologic inducers to elevate fetal hemoglobin and reduce sickle cell formation, Peslak SA, Khandros E, Huang P, Lan X, Geronimo CL, Grevet JD, Abdulmalik O, Zhang Z, Giardine BM, Keller CA, Shi J, Hardison RC, Blobel GA., 2020
The HRI-regulated transcription factor ATF4 activates BCL11A transcription to silence fetal hemoglobin expression, Huang P, Peslak SA, Lan X, Khandros E, Yano JA, Sharma M, Keller CA, Giardine B, Qin K, Abdulmalik O, Hardison RC, Shi J, Blobel GA., 2020
The E3 ligase adaptor molecule SPOP regulates fetal hemoglobin levels in adult erythroid cells, Lan X, Khandros E, Huang P, Peslak SA, Bhardwaj SK, Grevet JD, Abdulmalik O, Wang H, Keller CA, Giardine B, Baeza J, Duffner ER, El Demerdash O, Wu XS, Vakoc CR, Garcia BA, Hardison RC, Shi J, Blobel GA., 2019
Domain-focused CRISPR screen identifies HRI as a fetal hemoglobin regulator in human erythroid cells, Grevet JD*, Lan X* Hamagami N, Edwards CR, Sankaranarayanan L, Ji X, Bhardwaj SK, Face CJ, Posocco DF, Abdulmalik O, Keller CA, Giardine B, Sidoli S, Garcia BA, Chou ST, Liebhaber SA, Hardison RC, Shi J, Blobel GA., 2018
USP44 Is an Integral Component of N-CoR that Contributes to Gene Repression by Deubiquitinating Histone H2B, Lan X, Atanassov BS, Li W, Zhang Y, Florens L, Mohan RD, Galardy PJ, Washburn MP, Workman JL, Dent SYR., 2016
Cytoplasmic ATXN7L3B Interferes with Nuclear Functions of the SAGA Deubiquitinase Module, Li W, Atanassov BS, Lan X, Mohan RD, Swanson SK, Farria AT, Florens L, Washburn MP, Workman JL, Dent SY., 2016
ATXN7L3 and ENY2 Coordinate Activity of Multiple H2B Deubiquitinases Important for Cellular Proliferation and Tumor Growth, Atanassov BS, Mohan RD, Lan X, Kuang X, Lu Y, Lin K, McIvor E, Li W, Zhang Y, Florens L, Byrum SD, Mackintosh SG, Calhoun-Davis T, Koutelou E, Wang L, Tang DG, Tackett AJ, Washburn MP, Workman JL, Dent SY., 2016
Poly(Q) Expansions in ATXN7 Affect Solubility but Not Activity of the SAGA Deubiquitinating Module, Lan X*, Koutelou E*, Schibler AC, Chen YC, Grant PA, Dent SY., 2015

Crispr 生物化学多组学高通量测序生物信息学血红蛋白地中海贫血症转录因子 Znf410 肝癌

赵东宇 - 北京大学

吴华君 - 北京大学

Area of Focus
多组学 | 统计 | 数据分析 | 癌症 | 基因组学 | 生物信息学 | 计算生物学 | 研究 | 开发 | 应用

王勇波 - 复旦大学

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