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Yong Chu
Pharmaceutical Sciences
Fudan University
Shanghai
Language: Chinese, English
Drug Discovery
Small Molecules
Neurodegenerative Diseases
Imaging Probes
Gsk-3Β Inhibitors
Pet Tracers
Protein Modulators
Nmr Imaging Agents
Fluorescent Probes
Molecular Design
Areas of Focus
- Target-based original small molecule drug discovery
- Research on therapeutic drugs for neurodegenerative diseases and development of imaging diagnostic probes
Work Experience
- 2014/12-Present - Fudan University, School of Pharmacy, Department of Medicinal Chemistry - Associate Professor
- 2019 - Shanghai Drug Evaluation and Inspection Center - External Expert
- 2015-2017 - National Medical Products Administration, Center for Drug Evaluation - Drug Reviewer (Secondment)
- 2006/03-2014/12 - Fudan University, School of Pharmacy, Department of Medicinal Chemistry - Lecturer
- 2008/01-2009/02 - Georgia State University, Department of Chemistry - Postdoctoral Researcher
- 2004/08-2006/02 - Basilea Pharmaceutica (China) Ltd., Chemistry Department - R&D Team Leader
- 2002/06-2004/07 - Fudan University, Department of Chemistry - Postdoctoral Researcher
Academic Background & Achievements
- 1998/09-2001/12 Ph.D.: Sichuan University, West China School of Pharmacy
- 1995/09-1998/08 Master's: Kunming Institute of Precious Metals
- 1991/09-1995/07 Bachelor's: Xihua Normal University, Department of Chemistry
- Published over 30 papers in domestic and international academic journals
- Applied for over 20 Chinese invention patents, 8 authorized, 1 US patent application
- Co-authored 2 textbooks
Publications
- Discovery and anti-inflammatory evaluation of benzothiazepinones (BTZs) as novel non-ATP competitive inhibitors of glycogen synthase kinase-3β (GSK-3β), Yang Gao, Peng Zhang, Anfeng Cui, De-Yong Ye, Meng Xiang, Yong Chu, 2018
- The discovery of novel benzothiazinones as highly selective non-ATP competitive glycogen synthase kinase 3β inhibitors for the treatment of ovarian cancer, Yang Gao, Deyong Ye, Wei-cheng Zhou, Yong Chu, 2017
- An efficient one-pot procedure for the synthesis of 1,5-benzothiazepinones catalyzed by tetrabutylammonium fluoride (TBAF), Zhang, Peng, Ye, Deyong, Chu, Yong, 2016
- Novel Benzothiazinones (BTOs) as Allosteric Modulator or Substrate Competitive Inhibitor of Glycogen Synthase Kinase 3β (GSK-3β) with Cellular Activity of Promoting Glucose Uptake, Peng Zhang, Shufen Li, Yang Gao, Wenbo Lu, Ke Huang, De-Yong Ye, Xi Li, Yong Chu, 2014
- Design, Synthesis and Biological Evaluation of Benzothiazepinones (BTZs) as Novel Non-ATP Competitive Inhibitors of Glycogen Synthase Kinase-3β (GSK-3β), Peng Zhang, Hai-Rong Hu, Shi-Hui Bian, Zhao-Hui Huang, Yong Chu, De-Yong Ye, 2013
- Fluorescent conjugate of sLex-selective bisboronic acid for imaging application, Yong Chu, Danzhu Wang, Ke Wang, Zhiren (Luis) Liu, Brent Weston, Binghe Wang, 2013
- Identification of Novel Scaffold of Benzothiazepinones as Non-ATP Competitive Glycogen Synthase Kinase-3β Inhibitors through Virtual Screening, Peng Zhang, Hai-Rong Hu, Zhao-Hui Huang, Jia-Yi Lei, Yong Chu, De-Yong Ye, 2012
- Rational design of 2-pyrrolinones as inhibitors of HIV-1 integrase, Kaiqing Ma, Penghui Wang, Wei Fu, Xiaolong Wan, Yong Chu, Deyong Ye, 2011
- Using boronolectin in MALDI-MS imaging for the histological analysis of cancer tissue expressing the sialyl Lewis X antigen, Chaofeng Dai, Lisa H. Cazares, Lifang Wang, Yong Chu, Siming L. Wang, Dean A. Troyer, O. John Semmes, Richard R. Drake, Binghe Wang, 2011
