Professor | Yong Chu | Asia Growth Partners

	Upload Avatar (500 x 500)
Name	Yong Chu
Contact Information	cy110@fudan.edu.cn
Language ability	Chinese, English
Province	Shanghai

Upload Avatar (500 x 500)

Name

Yong Chu

Contact Information

cy110@fudan.edu.cn

Language ability

Chinese, English

Province

Shanghai

University/Lab Affiliation and Title	Fudan University
Faculty	Pharmaceutical Sciences
Academic Background & Achievements	1998/09-2001/12 Ph.D.: Sichuan University, West China School of Pharmacy 1995/09-1998/08 Master's: Kunming Institute of Precious Metals 1991/09-1995/07 Bachelor's: Xihua Normal University, Department of Chemistry Published over 30 papers in domestic and international academic journals Applied for over 20 Chinese invention patents, 8 authorized, 1 US patent application Co-authored 2 textbooks
Work Experience	2014/12-Present - Fudan University, School of Pharmacy, Department of Medicinal Chemistry - Associate Professor 2019 - Shanghai Drug Evaluation and Inspection Center - External Expert 2015-2017 - National Medical Products Administration, Center for Drug Evaluation - Drug Reviewer (Secondment) 2006/03-2014/12 - Fudan University, School of Pharmacy, Department of Medicinal Chemistry - Lecturer 2008/01-2009/02 - Georgia State University, Department of Chemistry - Postdoctoral Researcher 2004/08-2006/02 - Basilea Pharmaceutica (China) Ltd., Chemistry Department - R&D Team Leader 2002/06-2004/07 - Fudan University, Department of Chemistry - Postdoctoral Researcher

University/Lab Affiliation and Title

Fudan University

Faculty

Pharmaceutical Sciences

Academic Background & Achievements

1998/09-2001/12 Ph.D.: Sichuan University, West China School of Pharmacy
1995/09-1998/08 Master's: Kunming Institute of Precious Metals
1991/09-1995/07 Bachelor's: Xihua Normal University, Department of Chemistry
Published over 30 papers in domestic and international academic journals
Applied for over 20 Chinese invention patents, 8 authorized, 1 US patent application
Co-authored 2 textbooks

Work Experience

2014/12-Present - Fudan University, School of Pharmacy, Department of Medicinal Chemistry - Associate Professor
2019 - Shanghai Drug Evaluation and Inspection Center - External Expert
2015-2017 - National Medical Products Administration, Center for Drug Evaluation - Drug Reviewer (Secondment)
2006/03-2014/12 - Fudan University, School of Pharmacy, Department of Medicinal Chemistry - Lecturer
2008/01-2009/02 - Georgia State University, Department of Chemistry - Postdoctoral Researcher
2004/08-2006/02 - Basilea Pharmaceutica (China) Ltd., Chemistry Department - R&D Team Leader
2002/06-2004/07 - Fudan University, Department of Chemistry - Postdoctoral Researcher

Areas of Focus	Target-based original small molecule drug discovery Research on therapeutic drugs for neurodegenerative diseases and development of imaging diagnostic probes
Publications	Discovery and anti-inflammatory evaluation of benzothiazepinones (BTZs) as novel non-ATP competitive inhibitors of glycogen synthase kinase-3β (GSK-3β), Yang Gao, Peng Zhang, Anfeng Cui, De-Yong Ye, Meng Xiang, Yong Chu, 2018 The discovery of novel benzothiazinones as highly selective non-ATP competitive glycogen synthase kinase 3β inhibitors for the treatment of ovarian cancer, Yang Gao, Deyong Ye, Wei-cheng Zhou, Yong Chu, 2017 An efficient one-pot procedure for the synthesis of 1,5-benzothiazepinones catalyzed by tetrabutylammonium fluoride (TBAF), Zhang, Peng, Ye, Deyong, Chu, Yong, 2016 Novel Benzothiazinones (BTOs) as Allosteric Modulator or Substrate Competitive Inhibitor of Glycogen Synthase Kinase 3β (GSK-3β) with Cellular Activity of Promoting Glucose Uptake, Peng Zhang, Shufen Li, Yang Gao, Wenbo Lu, Ke Huang, De-Yong Ye, Xi Li, Yong Chu, 2014 Design, Synthesis and Biological Evaluation of Benzothiazepinones (BTZs) as Novel Non-ATP Competitive Inhibitors of Glycogen Synthase Kinase-3β (GSK-3β), Peng Zhang, Hai-Rong Hu, Shi-Hui Bian, Zhao-Hui Huang, Yong Chu, De-Yong Ye, 2013 Fluorescent conjugate of sLex-selective bisboronic acid for imaging application, Yong Chu, Danzhu Wang, Ke Wang, Zhiren (Luis) Liu, Brent Weston, Binghe Wang, 2013 Identification of Novel Scaffold of Benzothiazepinones as Non-ATP Competitive Glycogen Synthase Kinase-3β Inhibitors through Virtual Screening, Peng Zhang, Hai-Rong Hu, Zhao-Hui Huang, Jia-Yi Lei, Yong Chu, De-Yong Ye, 2012 Rational design of 2-pyrrolinones as inhibitors of HIV-1 integrase, Kaiqing Ma, Penghui Wang, Wei Fu, Xiaolong Wan, Yong Chu, Deyong Ye, 2011 Using boronolectin in MALDI-MS imaging for the histological analysis of cancer tissue expressing the sialyl Lewis X antigen, Chaofeng Dai, Lisa H. Cazares, Lifang Wang, Yong Chu, Siming L. Wang, Dean A. Troyer, O. John Semmes, Richard R. Drake, Binghe Wang, 2011

Areas of Focus

Target-based original small molecule drug discovery
Research on therapeutic drugs for neurodegenerative diseases and development of imaging diagnostic probes

Publications

Discovery and anti-inflammatory evaluation of benzothiazepinones (BTZs) as novel non-ATP competitive inhibitors of glycogen synthase kinase-3β (GSK-3β), Yang Gao, Peng Zhang, Anfeng Cui, De-Yong Ye, Meng Xiang, Yong Chu, 2018
The discovery of novel benzothiazinones as highly selective non-ATP competitive glycogen synthase kinase 3β inhibitors for the treatment of ovarian cancer, Yang Gao, Deyong Ye, Wei-cheng Zhou, Yong Chu, 2017
An efficient one-pot procedure for the synthesis of 1,5-benzothiazepinones catalyzed by tetrabutylammonium fluoride (TBAF), Zhang, Peng, Ye, Deyong, Chu, Yong, 2016
Novel Benzothiazinones (BTOs) as Allosteric Modulator or Substrate Competitive Inhibitor of Glycogen Synthase Kinase 3β (GSK-3β) with Cellular Activity of Promoting Glucose Uptake, Peng Zhang, Shufen Li, Yang Gao, Wenbo Lu, Ke Huang, De-Yong Ye, Xi Li, Yong Chu, 2014
Design, Synthesis and Biological Evaluation of Benzothiazepinones (BTZs) as Novel Non-ATP Competitive Inhibitors of Glycogen Synthase Kinase-3β (GSK-3β), Peng Zhang, Hai-Rong Hu, Shi-Hui Bian, Zhao-Hui Huang, Yong Chu, De-Yong Ye, 2013
Fluorescent conjugate of sLex-selective bisboronic acid for imaging application, Yong Chu, Danzhu Wang, Ke Wang, Zhiren (Luis) Liu, Brent Weston, Binghe Wang, 2013
Identification of Novel Scaffold of Benzothiazepinones as Non-ATP Competitive Glycogen Synthase Kinase-3β Inhibitors through Virtual Screening, Peng Zhang, Hai-Rong Hu, Zhao-Hui Huang, Jia-Yi Lei, Yong Chu, De-Yong Ye, 2012
Rational design of 2-pyrrolinones as inhibitors of HIV-1 integrase, Kaiqing Ma, Penghui Wang, Wei Fu, Xiaolong Wan, Yong Chu, Deyong Ye, 2011
Using boronolectin in MALDI-MS imaging for the histological analysis of cancer tissue expressing the sialyl Lewis X antigen, Chaofeng Dai, Lisa H. Cazares, Lifang Wang, Yong Chu, Siming L. Wang, Dean A. Troyer, O. John Semmes, Richard R. Drake, Binghe Wang, 2011

Drug Discovery Small Molecules Neurodegenerative Diseases Imaging Probes Gsk-3Β Inhibitors Pet Tracers Protein Modulators Nmr Imaging Agents Fluorescent Probes Molecular Design

Zhihong Cheng - Fudan University

Xiangbao Meng - Peking University

Xianfeng Gu - Fudan University

View All

Personal Information

Academic Information

Research

Contact us

No account yet?

Personal Information

Academic Information

Research

Contact us