Professor | Duanwu Zhang | Asia Growth Partners

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Name	Duanwu Zhang
Contact Information	duanwu@fudan.edu.cn
Language ability	Chinese, English
Province	Shanghai

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Name

Duanwu Zhang

Contact Information

duanwu@fudan.edu.cn

Language ability

Chinese, English

Province

Shanghai

University/Lab Affiliation and Title	Fudan University
Faculty	Biomedical Sciences
Academic Background & Achievements	2005.9-2009.9 Ph.D.: Xiamen University / The Scripps Research Institute 2001.9-2005.7 Bachelor's: Xiamen University, School of Life Sciences Published over 20 SCI papers with an average IF > 20 Cited over 3000 times Editorial board member of Front Immunol Committee member of the Shanghai Immunology Society's Infection Immunity Professional Committee
Work Experience	2019.9-Present - Fudan University - Young Researcher, PI at Biomedical Research Institute and Children's Hospital 2015.11-2019.8 - University of Texas Southwestern Medical Center - Instructor 2012.9-2015.10 - University of Texas Southwestern Medical Center - Postdoctoral Fellow 2009.10-2012.8 - Xiamen University - Postdoctoral Fellow
Awards	ELSEVIER Outstanding Reviewer Award (2016) Postdoctoral Research Award, University of Texas Southwestern Medical Center (2014) Second Prize, National Natural Science Award (2013) First Prize, Ministry of Education Natural Science Award (2010) National Excellent Doctoral Dissertation Award (2012) National Lu Jiaxi Excellent Graduate Student Award (2009)

University/Lab Affiliation and Title

Fudan University

Faculty

Biomedical Sciences

Academic Background & Achievements

2005.9-2009.9 Ph.D.: Xiamen University / The Scripps Research Institute
2001.9-2005.7 Bachelor's: Xiamen University, School of Life Sciences
Published over 20 SCI papers with an average IF > 20
Cited over 3000 times
Editorial board member of Front Immunol
Committee member of the Shanghai Immunology Society's Infection Immunity Professional Committee

Work Experience

2019.9-Present - Fudan University - Young Researcher, PI at Biomedical Research Institute and Children's Hospital
2015.11-2019.8 - University of Texas Southwestern Medical Center - Instructor
2012.9-2015.10 - University of Texas Southwestern Medical Center - Postdoctoral Fellow
2009.10-2012.8 - Xiamen University - Postdoctoral Fellow

Awards

ELSEVIER Outstanding Reviewer Award (2016)
Postdoctoral Research Award, University of Texas Southwestern Medical Center (2014)
Second Prize, National Natural Science Award (2013)
First Prize, Ministry of Education Natural Science Award (2010)
National Excellent Doctoral Dissertation Award (2012)
National Lu Jiaxi Excellent Graduate Student Award (2009)

Areas of Focus	Tumor Immunity Innate Immunity Immune Cell Development and Differentiation T Cell Function and Exhaustion
Publications	RIP3, an energy metabolism regulator that switches TNF-induced cell death from apoptosis to necrosis, Zhang D, Shao J, Lin J, Zhang N, Lu BJ, Lin SC, Dong MQ, Han J, 2009 Receptor-interacting protein (RIP) kinase family, Zhang D, Lin J, Han J, 2010 Programmed necrosis, backup to and competitor with apoptosis in the immune system, Han J, Zhong CQ, Zhang D, 2011 Multiple death pathways in TNF-treated fibroblasts: RIP3- and RIP1-dependent and independent routes, Zhang D, Zheng M, Zhao J, Li YY, Huang Z, Li Z, Han J, 2011 A role of RIP3-mediated macrophage necrosis in atherosclerosis development, Lin J, Li H, Yang M, Ren J, Huang Z, Han F, Huang J, Ma J, Zhang D, Zhang Z, Wu J, Huang D, Qiao M, Jin G, Wu Q, Huang Y, Du J, Han J, 2013 Regulator of G-protein signaling 19 (RGS19) and its partner Gα-inhibiting activity polypeptide 3 (GNAI3) are required for zVAD-induced autophagy and cell death in L929 cells, Wu T, Li Y, Huang D, Han F, Zhang YY, Zhang D, Han J, 2014 Real-time resolution of point mutations that cause phenovariance in mice, Wang T, Zhan X, Bu CH, Lyon S, Pratt D, Hildebrand S, Choi JH, Zhang Z, Zeng M, Wang KW, Turer E, Chen Z, Zhang D, Yue T,...Beutler B, 2015 Skin-specific regulation of SREBP processing and lipid biosynthesis by glycerol kinase 5, Zhang D, Tomisato W, Su L, Sun L, Choi JH, Zhang Z, Wang KW, Zhan X, Choi M, Li X, Tang M, Castro-Perez JM, Hildebrand S, Murray AR, Moresco EMY, Beutler B, 2017 IgD class switching is initiated by microbiota and limited to mucosa-associated lymphoid tissue in mice, Choi JH, Wang KW, Zhang D, Zhan X, Wang T, Bu CH, Behrendt CL, Zeng M, Wang Y, Misawa T, Li X, Tang M, Zhan X, Scott L, Hildebrand S, Murray AR, Moresco EM, Hooper LV, Beutler B, 2017 Syndromic immune disorder caused by a viable hypomorphic allele of spliceosome component Snrnp40, Zhang D, Yue T, Choi JH, Nair-Gill E, Zhong X, Wang KW, Zhan X, Li X, Choi M, Tang M, Quan J, Hildebrand S, Moresco EMY, Beutler B, 2019 Enhanced susceptibility to chemically induced colitis caused by excessive endosomal TLR signaling in LRBA-deficient mice, Wang KW, Zhan X, McAlpine W, Zhang Z, Choi JH, Shi H, Misawa T, Yue T, Zhang D, Wang Y, Ludwig S, Russell J, Tang M, Li X, Murray AR, Moresco EMY, Turer EE, Beutler B, 2019 LMBR1L regulates lymphopoiesis through Wnt/β-catenin signaling, Choi JH, Zhong X, McAlpine W, Liao TC, Zhang D, Fang B, Russell J, Ludwig S, Nair-Gill E, Zhang Z, Wang KW, Misawa T, Zhan X, Choi M, Wang T, Li X, Tang M, Sun Q, Yu L, Murray AR, Moresco EMY, Beutler B, 2019 SLFN2 protection of tRNAs from stress-induced cleavage is essential for T cell-mediated immunity, Yue T, Zhan X, Zhang D, Jain R, Wang KW, Choi JH, Misawa T, Su L, Quan J, Hildebrand S, Xu D, Li X, Turer E, Sun L, Moresco EMY, Beutler B, 2021 Emerging immune checkpoints in the tumor microenvironment: Implications for cancer immunotherapy, Wei G, Zhang H, Zhao H, Wang J, Wu N, Li L, Wu J, Zhang D, 2021 Emerging roles of spliceosome in cancer and immunity, Yang H, Beutler B, Zhang D, 2022 Understanding the immunosuppressive microenvironment of glioma: mechanistic insights and clinical perspectives, Lin H, Liu C, Hu A, Zhang D, Yang H, Mao Y, 2024

Areas of Focus

Tumor Immunity
Innate Immunity
Immune Cell Development and Differentiation
T Cell Function and Exhaustion

Publications

RIP3, an energy metabolism regulator that switches TNF-induced cell death from apoptosis to necrosis, Zhang D, Shao J, Lin J, Zhang N, Lu BJ, Lin SC, Dong MQ, Han J*, 2009
Receptor-interacting protein (RIP) kinase family, Zhang D, Lin J, Han J*, 2010
Programmed necrosis, backup to and competitor with apoptosis in the immune system, Han J, Zhong CQ, Zhang D, 2011
Multiple death pathways in TNF-treated fibroblasts: RIP3- and RIP1-dependent and independent routes, Zhang D, Zheng M, Zhao J, Li YY, Huang Z, Li Z, Han J*, 2011
A role of RIP3-mediated macrophage necrosis in atherosclerosis development, Lin J, Li H, Yang M, Ren J, Huang Z, Han F, Huang J, Ma J, Zhang D, Zhang Z, Wu J, Huang D, Qiao M, Jin G, Wu Q, Huang Y, Du J*, Han J*, 2013
Regulator of G-protein signaling 19 (RGS19) and its partner Gα-inhibiting activity polypeptide 3 (GNAI3) are required for zVAD-induced autophagy and cell death in L929 cells, Wu T, Li Y, Huang D, Han F, Zhang YY, Zhang D*, Han J*, 2014
Real-time resolution of point mutations that cause phenovariance in mice, Wang T, Zhan X, Bu CH, Lyon S, Pratt D, Hildebrand S, Choi JH, Zhang Z, Zeng M, Wang KW, Turer E, Chen Z, Zhang D, Yue T,...Beutler B*, 2015
Skin-specific regulation of SREBP processing and lipid biosynthesis by glycerol kinase 5, Zhang D, Tomisato W, Su L, Sun L, Choi JH, Zhang Z, Wang KW, Zhan X, Choi M, Li X, Tang M, Castro-Perez JM, Hildebrand S, Murray AR, Moresco EMY, Beutler B*, 2017
IgD class switching is initiated by microbiota and limited to mucosa-associated lymphoid tissue in mice, Choi JH, Wang KW, Zhang D, Zhan X, Wang T, Bu CH, Behrendt CL, Zeng M, Wang Y, Misawa T, Li X, Tang M, Zhan X, Scott L, Hildebrand S, Murray AR, Moresco EM, Hooper LV, Beutler B*, 2017
Syndromic immune disorder caused by a viable hypomorphic allele of spliceosome component Snrnp40, Zhang D, Yue T, Choi JH, Nair-Gill E, Zhong X, Wang KW, Zhan X, Li X, Choi M, Tang M, Quan J, Hildebrand S, Moresco EMY, Beutler B*, 2019
Enhanced susceptibility to chemically induced colitis caused by excessive endosomal TLR signaling in LRBA-deficient mice, Wang KW, Zhan X, McAlpine W, Zhang Z, Choi JH, Shi H, Misawa T, Yue T, Zhang D, Wang Y, Ludwig S, Russell J, Tang M, Li X, Murray AR, Moresco EMY, Turer EE, Beutler B*, 2019
LMBR1L regulates lymphopoiesis through Wnt/β-catenin signaling, Choi JH, Zhong X, McAlpine W, Liao TC, Zhang D, Fang B, Russell J, Ludwig S, Nair-Gill E, Zhang Z, Wang KW, Misawa T, Zhan X, Choi M, Wang T, Li X, Tang M, Sun Q, Yu L, Murray AR, Moresco EMY, Beutler B*, 2019
SLFN2 protection of tRNAs from stress-induced cleavage is essential for T cell-mediated immunity, Yue T, Zhan X, Zhang D, Jain R, Wang KW, Choi JH, Misawa T, Su L, Quan J, Hildebrand S, Xu D, Li X, Turer E, Sun L, Moresco EMY, Beutler B*, 2021
Emerging immune checkpoints in the tumor microenvironment: Implications for cancer immunotherapy, Wei G, Zhang H, Zhao H, Wang J, Wu N, Li L, Wu J, Zhang D*, 2021
Emerging roles of spliceosome in cancer and immunity, Yang H, Beutler B*, Zhang D*, 2022
Understanding the immunosuppressive microenvironment of glioma: mechanistic insights and clinical perspectives, Lin H, Liu C, Hu A, Zhang D*, Yang H*, Mao Y*, 2024

Tumor Immunity Cancer Inflammation Infectious Diseases Immune Signaling Biochemistry Molecular Biology Cell Biology Transcriptomics Proteomics

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