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Duanwu Zhang
Biomedical Sciences
Fudan University
Shanghai
Language: Chinese, English
Tumor Immunity
Cancer
Inflammation
Infectious Diseases
Immune Signaling
Biochemistry
Molecular Biology
Cell Biology
Transcriptomics
Proteomics
Areas of Focus
- Tumor Immunity
- Innate Immunity
- Immune Cell Development and Differentiation
- T Cell Function and Exhaustion
Work Experience
- 2019.9-Present - Fudan University - Young Researcher, PI at Biomedical Research Institute and Children's Hospital
- 2015.11-2019.8 - University of Texas Southwestern Medical Center - Instructor
- 2012.9-2015.10 - University of Texas Southwestern Medical Center - Postdoctoral Fellow
- 2009.10-2012.8 - Xiamen University - Postdoctoral Fellow
Academic Background & Achievements
- 2005.9-2009.9 Ph.D.: Xiamen University / The Scripps Research Institute
- 2001.9-2005.7 Bachelor's: Xiamen University, School of Life Sciences
- Published over 20 SCI papers with an average IF > 20
- Cited over 3000 times
- Editorial board member of Front Immunol
- Committee member of the Shanghai Immunology Society's Infection Immunity Professional Committee
Publications
- RIP3, an energy metabolism regulator that switches TNF-induced cell death from apoptosis to necrosis, Zhang D, Shao J, Lin J, Zhang N, Lu BJ, Lin SC, Dong MQ, Han J*, 2009
- Receptor-interacting protein (RIP) kinase family, Zhang D, Lin J, Han J*, 2010
- Programmed necrosis, backup to and competitor with apoptosis in the immune system, Han J, Zhong CQ, Zhang D, 2011
- Multiple death pathways in TNF-treated fibroblasts: RIP3- and RIP1-dependent and independent routes, Zhang D, Zheng M, Zhao J, Li YY, Huang Z, Li Z, Han J*, 2011
- A role of RIP3-mediated macrophage necrosis in atherosclerosis development, Lin J, Li H, Yang M, Ren J, Huang Z, Han F, Huang J, Ma J, Zhang D, Zhang Z, Wu J, Huang D, Qiao M, Jin G, Wu Q, Huang Y, Du J*, Han J*, 2013
- Regulator of G-protein signaling 19 (RGS19) and its partner Gα-inhibiting activity polypeptide 3 (GNAI3) are required for zVAD-induced autophagy and cell death in L929 cells, Wu T, Li Y, Huang D, Han F, Zhang YY, Zhang D*, Han J*, 2014
- Real-time resolution of point mutations that cause phenovariance in mice, Wang T, Zhan X, Bu CH, Lyon S, Pratt D, Hildebrand S, Choi JH, Zhang Z, Zeng M, Wang KW, Turer E, Chen Z, Zhang D, Yue T,...Beutler B*, 2015
- Skin-specific regulation of SREBP processing and lipid biosynthesis by glycerol kinase 5, Zhang D, Tomisato W, Su L, Sun L, Choi JH, Zhang Z, Wang KW, Zhan X, Choi M, Li X, Tang M, Castro-Perez JM, Hildebrand S, Murray AR, Moresco EMY, Beutler B*, 2017
- IgD class switching is initiated by microbiota and limited to mucosa-associated lymphoid tissue in mice, Choi JH, Wang KW, Zhang D, Zhan X, Wang T, Bu CH, Behrendt CL, Zeng M, Wang Y, Misawa T, Li X, Tang M, Zhan X, Scott L, Hildebrand S, Murray AR, Moresco EM, Hooper LV, Beutler B*, 2017
- Syndromic immune disorder caused by a viable hypomorphic allele of spliceosome component Snrnp40, Zhang D, Yue T, Choi JH, Nair-Gill E, Zhong X, Wang KW, Zhan X, Li X, Choi M, Tang M, Quan J, Hildebrand S, Moresco EMY, Beutler B*, 2019
- Enhanced susceptibility to chemically induced colitis caused by excessive endosomal TLR signaling in LRBA-deficient mice, Wang KW, Zhan X, McAlpine W, Zhang Z, Choi JH, Shi H, Misawa T, Yue T, Zhang D, Wang Y, Ludwig S, Russell J, Tang M, Li X, Murray AR, Moresco EMY, Turer EE, Beutler B*, 2019
- LMBR1L regulates lymphopoiesis through Wnt/β-catenin signaling, Choi JH, Zhong X, McAlpine W, Liao TC, Zhang D, Fang B, Russell J, Ludwig S, Nair-Gill E, Zhang Z, Wang KW, Misawa T, Zhan X, Choi M, Wang T, Li X, Tang M, Sun Q, Yu L, Murray AR, Moresco EMY, Beutler B*, 2019
- SLFN2 protection of tRNAs from stress-induced cleavage is essential for T cell-mediated immunity, Yue T, Zhan X, Zhang D, Jain R, Wang KW, Choi JH, Misawa T, Su L, Quan J, Hildebrand S, Xu D, Li X, Turer E, Sun L, Moresco EMY, Beutler B*, 2021
- Emerging immune checkpoints in the tumor microenvironment: Implications for cancer immunotherapy, Wei G, Zhang H, Zhao H, Wang J, Wu N, Li L, Wu J, Zhang D*, 2021
- Emerging roles of spliceosome in cancer and immunity, Yang H, Beutler B*, Zhang D*, 2022
- Understanding the immunosuppressive microenvironment of glioma: mechanistic insights and clinical perspectives, Lin H, Liu C, Hu A, Zhang D*, Yang H*, Mao Y*, 2024
Awards
- ELSEVIER Outstanding Reviewer Award (2016)
- Postdoctoral Research Award, University of Texas Southwestern Medical Center (2014)
- Second Prize, National Natural Science Award (2013)
- First Prize, Ministry of Education Natural Science Award (2010)
- National Excellent Doctoral Dissertation Award (2012)
- National Lu Jiaxi Excellent Graduate Student Award (2009)
