Upload Avatar (500 x 500)
Zhuohao He
Life Science
University of Chinese Academy of Sciences
Shanghai
Language: Chinese, English
Neurodegenerative Diseases
Pathogenesis
Model Construction
Alzheimer'S Disease
Neurodegeneration
Tau Protein
Neuronal Signaling
Protein Aggregation
Brain Injury
Cell Biology
Areas of Focus
- Pathogenesis and model construction of neurodegenerative diseases
Work Experience
- 2019-09~Present - Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences - Researcher
- 2018-03~2019-08 - University of Pennsylvania - Associate Researcher
- 2013-03~2018-02 - University of Pennsylvania - Postdoctoral Researcher
- 2012-01~2012-11 - Institute of Neuroscience, Chinese Academy of Sciences - Assistant Researcher
Academic Background & Achievements
- 2005-09--2012-01 Ph.D. in Science: Institute of Neuroscience, Chinese Academy of Sciences
- 2001-09--2005-07 Bachelor's in Science: Wuhan University
Publications
- MSUT2 regulates tau spreading via adenosinergic signaling mediated ASAP1 pathway in neurons, 3rd Author, 2024
- A microtubule stabilizer ameliorates protein pathogenesis and neurodegeneration in mouse models of repetitive traumatic brain injury, Corresponding Author, 2023
- Editorial: Multimodal interventions in Alzheimer's disease: from basic research to clinical practice, Corresponding Author, 2023
- Concomitant protein pathogenesis in Parkinson's disease and perspective mechanisms, Corresponding Author, 2023
- Specific binding of Hsp27 and phosphorylated Tau mitigates abnormal Tau aggregation- induced pathology, 13th Author, 2022
- SARS-CoV-2 promotes RIPK1 activation to facilitate viral propagation, 8th Author, 2021
- Insoluble Tau From Human FTDP-17 Cases Exhibit Unique Transmission Properties In Vivo, 3rd Author, 2020
- Modulating TRADD to restore cellular homeostasis and inhibit apoptosis, 21st Author, 2020
- Autosomal dominant VCP hypomorph mutation impairs disaggregation of PHF-tau, 9th Author, 2020
- Transmission of tauopathy strains is independent of their isoform composition, Corresponding Author, 2020
- Abeta Plaques Enhance Alzheimer Brain Tau Seeded Pathologies Via Facilitating Neuritic Plaque Tau Aggregation., 1st Author, 2018
- TRPC Channel Downstream Signaling Cascades, Corresponding Author, 2017
- Unique pathological tau conformers from Alzheimer’s brains transmit tau pathology in nontransgenic mice, 4th Author, 2016
- Ca2+ signaling initiated by canonical transient receptor potential channels in dendritic development, 2nd Author, 2015
- TRPC6 specifically interacts with APP to inhibit its cleavage by γ-secretase and reduce Aβ production, 5th Author, 2015
- TRPC5 Channel Is the Mediator of Neurotrophin-3 in Regulating Dendritic Growth via CaMKIIα in Rat Hippocampal Neurons, 1st Author, 2012
- Essential Role of TRPC6 Channels in G2/M Phase Transition and Development of Human Glioma, 2nd Author, 2010
- Targeting TRPC6 channels in oesophageal carcinoma growth. Expert opinion on therapeutic targets, 1st Author, 2010
- Critical role of TRPC6 channels in G2 phase transition and the development of human oesophageal cancer, Not mentioned, 2009
- TRPC6 channels promote dendritic growth via the CaMKIV-CREB pathway, 6th Author, 2008
- Pathological Tau Strains from Human Brains Recapitulate the Diversity of Tauopathies in Nontransgenic Mouse Brain, 7th Author
Awards
- Youth Neuroscientist Paper Award, 2nd Prize, Chinese Neuroscience Society, 2021
- AAIC2019, 2019
- Cold Spring Harbor Asia, 1st Prize, 2012
