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贺焯皓
Life Science
中国科学院大学
上海
Language: 中文, 英语
神经退行性疾病
病理发生
模型构建
阿兹海默症
神经退行
Tau蛋白
神经信号
蛋白质聚集
脑损伤
细胞生物学
Areas of Focus
- 神经退行性疾病病理发生机理及模型构建
Work Experience
- 2019-09~现在 - 中国科学院上海有机化学研究所 - 研究员
- 2018-03~2019-08 - 美国宾夕法尼亚大学 - 副研究员
- 2013-03~2018-02 - 美国宾夕法尼亚大学 - 博士后
- 2012-01~2012-11 - 中国科学院神经科学研究所 - 助理研究员
Academic Background & Achievements
- 2005-09--2012-01 理学博士: 中国科学院神经科学研究所
- 2001-09--2005-07 理学学士: 武汉大学
Publications
- MSUT2 regulates tau spreading via adenosinergic signaling mediated ASAP1 pathway in neurons, 第3作者, 2024
- A microtubule stabilizer ameliorates protein pathogenesis and neurodegeneration in mouse models of repetitive traumatic brain injury, 通讯作者, 2023
- Editorial: Multimodal interventions in Alzheimer's disease: from basic research to clinical practice, 通讯作者, 2023
- Concomitant protein pathogenesis in Parkinson's disease and perspective mechanisms, 通讯作者, 2023
- Specific binding of Hsp27 and phosphorylated Tau mitigates abnormal Tau aggregation- induced pathology, 第13作者, 2022
- SARS-CoV-2 promotes RIPK1 activation to facilitate viral propagation, 第8作者, 2021
- Insoluble Tau From Human FTDP-17 Cases Exhibit Unique Transmission Properties In Vivo, 第3作者, 2020
- Modulating TRADD to restore cellular homeostasis and inhibit apoptosis, 第21作者, 2020
- Autosomal dominant VCP hypomorph mutation impairs disaggregation of PHF-tau, 第9作者, 2020
- Transmission of tauopathy strains is independent of their isoform composition, 通讯作者, 2020
- Abeta Plaques Enhance Alzheimer Brain Tau Seeded Pathologies Via Facilitating Neuritic Plaque Tau Aggregation., 第1作者, 2018
- TRPC Channel Downstream Signaling Cascades, 通讯作者, 2017
- Unique pathological tau conformers from Alzheimer’s brains transmit tau pathology in nontransgenic mice, 第4作者, 2016
- Ca2+ signaling initiated by canonical transient receptor potential channels in dendritic development, 第2作者, 2015
- TRPC6 specifically interacts with APP to inhibit its cleavage by γ-secretase and reduce Aβ production, 第5作者, 2015
- TRPC5 Channel Is the Mediator of Neurotrophin-3 in Regulating Dendritic Growth via CaMKIIα in Rat Hippocampal Neurons, 第1作者, 2012
- Essential Role of TRPC6 Channels in G2/M Phase Transition and Development of Human Glioma, 第2作者, 2010
- Targeting TRPC6 channels in oesophageal carcinoma growth. Expert opinion on therapeutic targets, 第1作者, 2010
- Critical role of TRPC6 channels in G2 phase transition and the development of human oesophageal cancer, 未提及, 2009
- TRPC6 channels promote dendritic growth via the CaMKIV-CREB pathway, 第6作者, 2008
- Pathological Tau Strains from Human Brains Recapitulate the Diversity of Tauopathies in Nontransgenic Mouse Brain, 第7作者
Awards
- 青年神经科学家论文报告奖, 二等奖, 中国神经科学学会, 2021
- AAIC2019, 2019
- 冷泉港亚洲, 一等奖, 2012
