Professor | 贺焯皓 | 数字化转型顾问

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Name	贺焯皓
Contact Information	hezh@sioc.ac.cn
Language ability	中文, 英语
Province	上海

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Name

贺焯皓

Contact Information

hezh@sioc.ac.cn

Language ability

中文, 英语

Province

上海

University/Lab Affiliation and Title	中国科学院大学
Faculty	Life Sciences
Academic Background & Achievements	2005-09--2012-01 理学博士: 中国科学院神经科学研究所 2001-09--2005-07 理学学士: 武汉大学
Work Experience	2019-09~现在 - 中国科学院上海有机化学研究所 - 研究员 2018-03~2019-08 - 美国宾夕法尼亚大学 - 副研究员 2013-03~2018-02 - 美国宾夕法尼亚大学 - 博士后 2012-01~2012-11 - 中国科学院神经科学研究所 - 助理研究员
Awards	青年神经科学家论文报告奖, 二等奖, 中国神经科学学会, 2021 AAIC2019, 2019 冷泉港亚洲, 一等奖, 2012

University/Lab Affiliation and Title

中国科学院大学

Faculty

Life Sciences

Academic Background & Achievements

2005-09--2012-01 理学博士: 中国科学院神经科学研究所
2001-09--2005-07 理学学士: 武汉大学

Work Experience

2019-09~现在 - 中国科学院上海有机化学研究所 - 研究员
2018-03~2019-08 - 美国宾夕法尼亚大学 - 副研究员
2013-03~2018-02 - 美国宾夕法尼亚大学 - 博士后
2012-01~2012-11 - 中国科学院神经科学研究所 - 助理研究员

Awards

青年神经科学家论文报告奖, 二等奖, 中国神经科学学会, 2021
AAIC2019, 2019
冷泉港亚洲, 一等奖, 2012

Areas of Focus	神经退行性疾病病理发生机理及模型构建
Publications	MSUT2 regulates tau spreading via adenosinergic signaling mediated ASAP1 pathway in neurons, 第3作者, 2024 A microtubule stabilizer ameliorates protein pathogenesis and neurodegeneration in mouse models of repetitive traumatic brain injury, 通讯作者, 2023 Editorial: Multimodal interventions in Alzheimer's disease: from basic research to clinical practice, 通讯作者, 2023 Concomitant protein pathogenesis in Parkinson's disease and perspective mechanisms, 通讯作者, 2023 Specific binding of Hsp27 and phosphorylated Tau mitigates abnormal Tau aggregation- induced pathology, 第13作者, 2022 SARS-CoV-2 promotes RIPK1 activation to facilitate viral propagation, 第8作者, 2021 Insoluble Tau From Human FTDP-17 Cases Exhibit Unique Transmission Properties In Vivo, 第3作者, 2020 Modulating TRADD to restore cellular homeostasis and inhibit apoptosis, 第21作者, 2020 Autosomal dominant VCP hypomorph mutation impairs disaggregation of PHF-tau, 第9作者, 2020 Transmission of tauopathy strains is independent of their isoform composition, 通讯作者, 2020 Abeta Plaques Enhance Alzheimer Brain Tau Seeded Pathologies Via Facilitating Neuritic Plaque Tau Aggregation., 第1作者, 2018 TRPC Channel Downstream Signaling Cascades, 通讯作者, 2017 Unique pathological tau conformers from Alzheimer’s brains transmit tau pathology in nontransgenic mice, 第4作者, 2016 Ca2+ signaling initiated by canonical transient receptor potential channels in dendritic development, 第2作者, 2015 TRPC6 specifically interacts with APP to inhibit its cleavage by γ-secretase and reduce Aβ production, 第5作者, 2015 TRPC5 Channel Is the Mediator of Neurotrophin-3 in Regulating Dendritic Growth via CaMKIIα in Rat Hippocampal Neurons, 第1作者, 2012 Essential Role of TRPC6 Channels in G2/M Phase Transition and Development of Human Glioma, 第2作者, 2010 Targeting TRPC6 channels in oesophageal carcinoma growth. Expert opinion on therapeutic targets, 第1作者, 2010 Critical role of TRPC6 channels in G2 phase transition and the development of human oesophageal cancer, 未提及, 2009 TRPC6 channels promote dendritic growth via the CaMKIV-CREB pathway, 第6作者, 2008 Pathological Tau Strains from Human Brains Recapitulate the Diversity of Tauopathies in Nontransgenic Mouse Brain, 第7作者

Areas of Focus

神经退行性疾病病理发生机理及模型构建

Publications

MSUT2 regulates tau spreading via adenosinergic signaling mediated ASAP1 pathway in neurons, 第3作者, 2024
A microtubule stabilizer ameliorates protein pathogenesis and neurodegeneration in mouse models of repetitive traumatic brain injury, 通讯作者, 2023
Editorial: Multimodal interventions in Alzheimer's disease: from basic research to clinical practice, 通讯作者, 2023
Concomitant protein pathogenesis in Parkinson's disease and perspective mechanisms, 通讯作者, 2023
Specific binding of Hsp27 and phosphorylated Tau mitigates abnormal Tau aggregation- induced pathology, 第13作者, 2022
SARS-CoV-2 promotes RIPK1 activation to facilitate viral propagation, 第8作者, 2021
Insoluble Tau From Human FTDP-17 Cases Exhibit Unique Transmission Properties In Vivo, 第3作者, 2020
Modulating TRADD to restore cellular homeostasis and inhibit apoptosis, 第21作者, 2020
Autosomal dominant VCP hypomorph mutation impairs disaggregation of PHF-tau, 第9作者, 2020
Transmission of tauopathy strains is independent of their isoform composition, 通讯作者, 2020
Abeta Plaques Enhance Alzheimer Brain Tau Seeded Pathologies Via Facilitating Neuritic Plaque Tau Aggregation., 第1作者, 2018
TRPC Channel Downstream Signaling Cascades, 通讯作者, 2017
Unique pathological tau conformers from Alzheimer’s brains transmit tau pathology in nontransgenic mice, 第4作者, 2016
Ca2+ signaling initiated by canonical transient receptor potential channels in dendritic development, 第2作者, 2015
TRPC6 specifically interacts with APP to inhibit its cleavage by γ-secretase and reduce Aβ production, 第5作者, 2015
TRPC5 Channel Is the Mediator of Neurotrophin-3 in Regulating Dendritic Growth via CaMKIIα in Rat Hippocampal Neurons, 第1作者, 2012
Essential Role of TRPC6 Channels in G2/M Phase Transition and Development of Human Glioma, 第2作者, 2010
Targeting TRPC6 channels in oesophageal carcinoma growth. Expert opinion on therapeutic targets, 第1作者, 2010
Critical role of TRPC6 channels in G2 phase transition and the development of human oesophageal cancer, 未提及, 2009
TRPC6 channels promote dendritic growth via the CaMKIV-CREB pathway, 第6作者, 2008
Pathological Tau Strains from Human Brains Recapitulate the Diversity of Tauopathies in Nontransgenic Mouse Brain, 第7作者

神经退行性疾病病理发生模型构建阿兹海默症神经退行 Tau蛋白神经信号蛋白质聚集脑损伤细胞生物学

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