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Xinjian Li
Life Science
University of Chinese Academy of Sciences
Beijing
Language: Chinese, English
Metabolism
Tumor
Reprogramming
Glycolysis
Tca Cycle
Urea Cycle
Nucleotide Metabolism
Fatty Acid Metabolism
Cholesterol Metabolism
Glutamine Metabolism
Areas of Focus
- Metabolic Reprogramming in Tumor Cells
- Metabolic Reprogramming in Vascular Endothelial Cells
Work Experience
- 2019-01~Present - Institute of Biophysics, Chinese Academy of Sciences - Researcher
- 2016-11~2019-01 - MD Anderson Cancer Center, USA - Lecturer
- 2011-11~2016-10 - MD Anderson Cancer Center, USA - Postdoctoral Fellow
Academic Background & Achievements
- 2007-09--2011-07 PhD: Sun Yat-sen University
- 2004-09--2007-07 Master's: South China University of Technology
- 2000-09--2004-07 Bachelor's: South China Agricultural University
Publications
- Programmable Base Editing of Mutated TERT Promoter Inhibits Brain Tumor Growth, Nature Cell Biology, 2020
- KDM3A Senses Oxygen Availability to Regulate PGC-1α-Mediated Mitochondrial Biogenesis, Molecular Cell, 2019
- PTEN Suppresses Glycolysis by Dephosphorylating and Inhibiting Autophosphorylated PGK1, Molecular Cell, 2019
- Nuclear PGK1 alleviates ADP-dependent inhibition of CDC7 to promote DNA replication, Molecular Cell, 2018
- Regulation of chromatin and gene expression by metabolic enzymes and metabolites, Nature Reviews Molecular Cell Biology, 2018
- Conversion of PRPS hexamer to monomer by AMPK-mediated phosphorylation inhibits nucleotide synthesis in response to energy stress, Cancer Discovery, 2018
- Nucleus-translocated ACSS2 promotes the gene transcription for lysosomal biogenesis and autophagy, Molecular Cell, 2017
- A splicing switch from ketohexokinase-C to ketohexokinase-A drives hepatocellular carcinoma formation, Nature Cell Biology, 2016
- Mitochondria-Translocated PGK1 Functions as a Protein Kinase to Coordinate Glycolysis and the TCA Cycle in Tumorigenesis, Molecular Cell, 2016
Awards
- USCACA-AFCR Scholarship (2018): Other
- Caroline Ross Endowed Fellowship (2016): MD Anderson Cancer Center
- The Harold C. and Mary L. Daily Endowment Fund Fellowship (2016): MD Anderson Cancer Center
- The Anne Eastland Spears Fellowship (2015): MD Anderson Cancer Center
- Odyssey Fellowship (2013): MD Anderson Cancer Center
