Professor | Xinjian Li | Asia Growth Partners

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Name	Xinjian Li
Contact Information	lixinjian@ibp.ac.cn
Language ability	Chinese, English
Province	Beijing

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Name

Xinjian Li

Contact Information

lixinjian@ibp.ac.cn

Language ability

Chinese, English

Province

Beijing

University/Lab Affiliation and Title	University of Chinese Academy of Sciences
Faculty	Life Sciences
Academic Background & Achievements	2007-09--2011-07 PhD: Sun Yat-sen University 2004-09--2007-07 Master's: South China University of Technology 2000-09--2004-07 Bachelor's: South China Agricultural University
Work Experience	2019-01~Present - Institute of Biophysics, Chinese Academy of Sciences - Researcher 2016-11~2019-01 - MD Anderson Cancer Center, USA - Lecturer 2011-11~2016-10 - MD Anderson Cancer Center, USA - Postdoctoral Fellow
Awards	USCACA-AFCR Scholarship (2018): Other Caroline Ross Endowed Fellowship (2016): MD Anderson Cancer Center The Harold C. and Mary L. Daily Endowment Fund Fellowship (2016): MD Anderson Cancer Center The Anne Eastland Spears Fellowship (2015): MD Anderson Cancer Center Odyssey Fellowship (2013): MD Anderson Cancer Center

University/Lab Affiliation and Title

University of Chinese Academy of Sciences

Faculty

Life Sciences

Academic Background & Achievements

2007-09--2011-07 PhD: Sun Yat-sen University
2004-09--2007-07 Master's: South China University of Technology
2000-09--2004-07 Bachelor's: South China Agricultural University

Work Experience

2019-01~Present - Institute of Biophysics, Chinese Academy of Sciences - Researcher
2016-11~2019-01 - MD Anderson Cancer Center, USA - Lecturer
2011-11~2016-10 - MD Anderson Cancer Center, USA - Postdoctoral Fellow

Awards

USCACA-AFCR Scholarship (2018): Other
Caroline Ross Endowed Fellowship (2016): MD Anderson Cancer Center
The Harold C. and Mary L. Daily Endowment Fund Fellowship (2016): MD Anderson Cancer Center
The Anne Eastland Spears Fellowship (2015): MD Anderson Cancer Center
Odyssey Fellowship (2013): MD Anderson Cancer Center

Areas of Focus	Metabolic Reprogramming in Tumor Cells Metabolic Reprogramming in Vascular Endothelial Cells
Publications	Programmable Base Editing of Mutated TERT Promoter Inhibits Brain Tumor Growth, Nature Cell Biology, 2020 KDM3A Senses Oxygen Availability to Regulate PGC-1α-Mediated Mitochondrial Biogenesis, Molecular Cell, 2019 PTEN Suppresses Glycolysis by Dephosphorylating and Inhibiting Autophosphorylated PGK1, Molecular Cell, 2019 Nuclear PGK1 alleviates ADP-dependent inhibition of CDC7 to promote DNA replication, Molecular Cell, 2018 Regulation of chromatin and gene expression by metabolic enzymes and metabolites, Nature Reviews Molecular Cell Biology, 2018 Conversion of PRPS hexamer to monomer by AMPK-mediated phosphorylation inhibits nucleotide synthesis in response to energy stress, Cancer Discovery, 2018 Nucleus-translocated ACSS2 promotes the gene transcription for lysosomal biogenesis and autophagy, Molecular Cell, 2017 A splicing switch from ketohexokinase-C to ketohexokinase-A drives hepatocellular carcinoma formation, Nature Cell Biology, 2016 Mitochondria-Translocated PGK1 Functions as a Protein Kinase to Coordinate Glycolysis and the TCA Cycle in Tumorigenesis, Molecular Cell, 2016

Areas of Focus

Metabolic Reprogramming in Tumor Cells
Metabolic Reprogramming in Vascular Endothelial Cells

Publications

Programmable Base Editing of Mutated TERT Promoter Inhibits Brain Tumor Growth, Nature Cell Biology, 2020
KDM3A Senses Oxygen Availability to Regulate PGC-1α-Mediated Mitochondrial Biogenesis, Molecular Cell, 2019
PTEN Suppresses Glycolysis by Dephosphorylating and Inhibiting Autophosphorylated PGK1, Molecular Cell, 2019
Nuclear PGK1 alleviates ADP-dependent inhibition of CDC7 to promote DNA replication, Molecular Cell, 2018
Regulation of chromatin and gene expression by metabolic enzymes and metabolites, Nature Reviews Molecular Cell Biology, 2018
Conversion of PRPS hexamer to monomer by AMPK-mediated phosphorylation inhibits nucleotide synthesis in response to energy stress, Cancer Discovery, 2018
Nucleus-translocated ACSS2 promotes the gene transcription for lysosomal biogenesis and autophagy, Molecular Cell, 2017
A splicing switch from ketohexokinase-C to ketohexokinase-A drives hepatocellular carcinoma formation, Nature Cell Biology, 2016
Mitochondria-Translocated PGK1 Functions as a Protein Kinase to Coordinate Glycolysis and the TCA Cycle in Tumorigenesis, Molecular Cell, 2016

Metabolism Tumor Reprogramming Glycolysis Tca Cycle Urea Cycle Nucleotide Metabolism Fatty Acid Metabolism Cholesterol Metabolism Glutamine Metabolism

Ning Yan - Tsinghua University

Jiang Peng - Tsinghua University

Dan Huang - Southern University of Science and Technology

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