Professor | 李新建 | 数字化转型顾问

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Name

李新建

Contact Information

lixinjian@ibp.ac.cn

Language ability

中文, 英语

Province

北京

University/Lab Affiliation and Title	中国科学院大学
Faculty	Life Sciences
Academic Background & Achievements	2007-09--2011-07 博士: 中山大学 2004-09--2007-07 硕士: 华南理工大学 2000-09--2004-07 学士: 华南农业大学
Work Experience	2019-01~现在 - 中国科学院生物物理研究所 - 研究员 2016-11~2019-01 - 美国MD安德森癌症中心 - 讲师 2011-11~2016-10 - 美国MD安德森癌症中心 - 博士后
Awards	美中抗癌协会和美国亚洲癌症研究基金会（USCACA-AFCR）奖学金 (2018): 其他 MD安德森癌症中心Caroline Ross Endowed Fellowship (2016): 研究所（学校） MD安德森癌症中心The Harold C. and Mary L. Daily Endowment Fund Fellowship (2016): 研究所（学校） MD安德森癌症中心The Anne Eastland Spears Fellowship (2015): 研究所（学校） MD安德森癌症中心Odyssey Fellowship (2013): 研究所（学校）

University/Lab Affiliation and Title

中国科学院大学

Faculty

Life Sciences

Academic Background & Achievements

Work Experience

Awards

美中抗癌协会和美国亚洲癌症研究基金会（USCACA-AFCR）奖学金 (2018): 其他
MD安德森癌症中心Caroline Ross Endowed Fellowship (2016): 研究所（学校）
MD安德森癌症中心The Harold C. and Mary L. Daily Endowment Fund Fellowship (2016): 研究所（学校）
MD安德森癌症中心The Anne Eastland Spears Fellowship (2015): 研究所（学校）
MD安德森癌症中心Odyssey Fellowship (2013): 研究所（学校）

Areas of Focus	肿瘤细胞的代谢重编程血管内皮细胞的代谢重编程
Publications	Programmable Base Editing of Mutated TERT Promoter Inhibits Brain Tumor Growth, Nature Cell Biology, 2020 KDM3A Senses Oxygen Availability to Regulate PGC-1α-Mediated Mitochondrial Biogenesis, Molecular Cell, 2019 PTEN Suppresses Glycolysis by Dephosphorylating and Inhibiting Autophosphorylated PGK1, Molecular Cell, 2019 Nuclear PGK1 alleviates ADP-dependent inhibition of CDC7 to promote DNA replication, Molecular Cell, 2018 Regulation of chromatin and gene expression by metabolic enzymes and metabolites, Nature Reviews Molecular Cell Biology, 2018 Conversion of PRPS hexamer to monomer by AMPK-mediated phosphorylation inhibits nucleotide synthesis in response to energy stress, Cancer Discovery, 2018 Nucleus-translocated ACSS2 promotes the gene transcription for lysosomal biogenesis and autophagy, Molecular Cell, 2017 A splicing switch from ketohexokinase-C to ketohexokinase-A drives hepatocellular carcinoma formation, Nature Cell Biology, 2016 Mitochondria-Translocated PGK1 Functions as a Protein Kinase to Coordinate Glycolysis and the TCA Cycle in Tumorigenesis, Molecular Cell, 2016

Areas of Focus

肿瘤细胞的代谢重编程
血管内皮细胞的代谢重编程

Publications

Programmable Base Editing of Mutated TERT Promoter Inhibits Brain Tumor Growth, Nature Cell Biology, 2020
KDM3A Senses Oxygen Availability to Regulate PGC-1α-Mediated Mitochondrial Biogenesis, Molecular Cell, 2019
PTEN Suppresses Glycolysis by Dephosphorylating and Inhibiting Autophosphorylated PGK1, Molecular Cell, 2019
Nuclear PGK1 alleviates ADP-dependent inhibition of CDC7 to promote DNA replication, Molecular Cell, 2018
Regulation of chromatin and gene expression by metabolic enzymes and metabolites, Nature Reviews Molecular Cell Biology, 2018
Conversion of PRPS hexamer to monomer by AMPK-mediated phosphorylation inhibits nucleotide synthesis in response to energy stress, Cancer Discovery, 2018
Nucleus-translocated ACSS2 promotes the gene transcription for lysosomal biogenesis and autophagy, Molecular Cell, 2017
A splicing switch from ketohexokinase-C to ketohexokinase-A drives hepatocellular carcinoma formation, Nature Cell Biology, 2016
Mitochondria-Translocated PGK1 Functions as a Protein Kinase to Coordinate Glycolysis and the TCA Cycle in Tumorigenesis, Molecular Cell, 2016

代谢肿瘤重编程糖酵解三羧酸循环尿素循环核苷酸代谢脂肪酸代谢胆固醇代谢谷氨酰胺代谢

江鹏 - 清华大学

黄丹 - 南方科技大学

Area of Focus
基因组学 | 进化 | 转录 | 调控 | 肿瘤 | 代谢 | 肿瘤学 | 生物信息学 | 数据分析 | 分子生物学

饶枫 - 南方科技大学

Area of Focus
细胞内 | 代谢 | 信使 | 调控 | 蛋白质 | 稳态 | 疾病 | 神经 | 肿瘤 | 互动

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