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李新建
Life Science
中国科学院大学
北京
Language: 中文, 英语
代谢
肿瘤
重编程
糖酵解
三羧酸循环
尿素循环
核苷酸代谢
脂肪酸代谢
胆固醇代谢
谷氨酰胺代谢
Areas of Focus
- 肿瘤细胞的代谢重编程
- 血管内皮细胞的代谢重编程
Work Experience
- 2019-01~现在 - 中国科学院生物物理研究所 - 研究员
- 2016-11~2019-01 - 美国MD安德森癌症中心 - 讲师
- 2011-11~2016-10 - 美国MD安德森癌症中心 - 博士后
Academic Background & Achievements
- 2007-09--2011-07 博士: 中山大学
- 2004-09--2007-07 硕士: 华南理工大学
- 2000-09--2004-07 学士: 华南农业大学
Publications
- Programmable Base Editing of Mutated TERT Promoter Inhibits Brain Tumor Growth, Nature Cell Biology, 2020
- KDM3A Senses Oxygen Availability to Regulate PGC-1α-Mediated Mitochondrial Biogenesis, Molecular Cell, 2019
- PTEN Suppresses Glycolysis by Dephosphorylating and Inhibiting Autophosphorylated PGK1, Molecular Cell, 2019
- Nuclear PGK1 alleviates ADP-dependent inhibition of CDC7 to promote DNA replication, Molecular Cell, 2018
- Regulation of chromatin and gene expression by metabolic enzymes and metabolites, Nature Reviews Molecular Cell Biology, 2018
- Conversion of PRPS hexamer to monomer by AMPK-mediated phosphorylation inhibits nucleotide synthesis in response to energy stress, Cancer Discovery, 2018
- Nucleus-translocated ACSS2 promotes the gene transcription for lysosomal biogenesis and autophagy, Molecular Cell, 2017
- A splicing switch from ketohexokinase-C to ketohexokinase-A drives hepatocellular carcinoma formation, Nature Cell Biology, 2016
- Mitochondria-Translocated PGK1 Functions as a Protein Kinase to Coordinate Glycolysis and the TCA Cycle in Tumorigenesis, Molecular Cell, 2016
Awards
- 美中抗癌协会和美国亚洲癌症研究基金会（USCACA-AFCR）奖学金 (2018): 其他
- MD安德森癌症中心Caroline Ross Endowed Fellowship (2016): 研究所（学校）
- MD安德森癌症中心The Harold C. and Mary L. Daily Endowment Fund Fellowship (2016): 研究所（学校）
- MD安德森癌症中心The Anne Eastland Spears Fellowship (2015): 研究所（学校）
- MD安德森癌症中心Odyssey Fellowship (2013): 研究所（学校）
