Professor | Yu Chen | Asia Growth Partners

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Name	Yu Chen
Contact Information	y_chen@tongji.edu.cn
Language ability	Chinese, English
Province	Shanghai

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Name

Yu Chen

Contact Information

y_chen@tongji.edu.cn

Language ability

Chinese, English

Province

Shanghai

University/Lab Affiliation and Title	Tongji University
Faculty	Life Sciences
Academic Background & Achievements	PhD Degree Hosts national youth projects and Shanghai science and technology projects Published as first and corresponding author in high-impact journals
Work Experience	2023-Present - Tongji University - Assistant Professor, Master's Supervisor 2022-2023 - Tongji University Affiliated Hospital - Assistant Researcher 2021-2022 - Tongji University Affiliated Hospital - Research Intern
Awards	2023 - Best Expression Award at National Youth Excellent Physiology Academic Report 2022 - Shanghai Medical Science and Technology Award 2021 - Tongji University Excellence Award 2022 - Tongji University Outstanding Doctoral Thesis

University/Lab Affiliation and Title

Tongji University

Faculty

Life Sciences

Academic Background & Achievements

PhD Degree
Hosts national youth projects and Shanghai science and technology projects
Published as first and corresponding author in high-impact journals

Work Experience

2023-Present - Tongji University - Assistant Professor, Master's Supervisor
2022-2023 - Tongji University Affiliated Hospital - Assistant Researcher
2021-2022 - Tongji University Affiliated Hospital - Research Intern

Awards

2023 - Best Expression Award at National Youth Excellent Physiology Academic Report
2022 - Shanghai Medical Science and Technology Award
2021 - Tongji University Excellence Award
2022 - Tongji University Outstanding Doctoral Thesis

Areas of Focus	Regulation of aging and genomic stability Mechanisms of DNA repair and aging Development of anti-aging and related disease strategies
Publications	Impaired end joining induces cardiac atrophy in a Hutchinson-Gilford progeria mouse model, Chen Y, Huang S, Cui Z, Sun X, Tang Y, Zhang H, Chen Z, Jiang R, Zhang W, Li X, Chen J, Liu B, Jiang Y, Wei K, Mao Z, 2023 Androgen signaling stabilizes genomes to counteract senescence by promoting XRCC4 transcription, Chen Y, Zhen Z, Chen L, Wang H, Wang X, Sun X, Song Z, Wang H, Lin Y, Zhang W, Wu G, Jiang Y, Mao Z, 2023 Nuclear cGAS restricts L1 retrotransposition by promoting TRIM41-mediated ORF2p ubiquitination and degradation, Zhen Z, Chen Y, Wang H, Tang H, Zhang H, Liu H, Jiang Y, Mao Z, 2023 Circadian factors CLOCK and BMAL1 promote nonhomologous end joining and antagonize cellular senescence, Chen Y, Xu X, Chen Z, Chen L, Jiang Y, Mao Z, 2024 A PARP1-BRG1-SIRT1 axis promotes HR repair by reducing nucleosome density at DNA damage sites, Chen Y, Zhang H, Xu Z, Tang H, Geng A, Cai B, Su T, Shi J, Jiang C, Tian X, Seluanov A, Huang J, Wan X, Jiang Y, Gorbunova V, Mao Z, 2019 IDDoR: a novel reporter mouse system for simultaneous and quantitative in vivo analysis of both DNA double-strand break repair pathways, Chen Y, Cui Z, Chen Z, Jiang Y, Mao Z, 2023 The SIRT6 activator MDL-800 improves genomic stability and pluripotency of old murine-derived iPS cells, Chen Y, Chen J, Sun X, Yu J, Qian Z, Wu L, Xu X, Wan X, Jiang Y, Zhang J, Gao S, Mao Z, 2020 A high-throughput small molecule screen identifies farrerol as a potentiator of CRISPR/Cas9-mediated genome editing, Zhang W, Chen Y, Yang J, Zhang J, Yu J, Wang M, Zhao X, Wei K, Wan X, Xu X, Jiang Y, Chen J, Gao S, Mao Z, 2020 Fight to the bitter end: DNA repair and aging, Chen Y, Geng A, Zhang W, Qian Z, Wan X, Jiang Y, Mao Z, 2020 Use of the XRCC2 promoter for in vivo cancer diagnosis and therapy, Chen Y, Li Z, Xu Z, Tang H, Guo W, Sun X, Zhang W, Zhang J, Wan X, Jiang Y, Mao Z, 2018 DNA double-strand break repair and nucleic acid-related immunity, Zhang H, Chen Y, Jiang Y, Mao Z, 2022 The landscape of aging, Cai Y, Song W, Li J, Jing Y, Liang C, Zhang L, Zhang X, Zhang W, Liu B, An Y, Li J, Tang B, Pei S, Wu X, Liu Y, Zhuang C, Ying Y, Dou X, Chen Y, Xiao F, Li D, Yang R, Zhao Y, Wang Y, Wang L, Li Y, Ma S, Wang S, Song X, Ren J, Zhang L, Wang J, Zhang W, Xie Z, Qu J, Wang J, Xiao Y, Tian Y, Wang G, Hu P, Ye J, Sun Y, Mao Z, Kong Q, Liu Q, Zou W, Tian X, Xiao Z, Liu Y, Liu J, Song M, Han J, Liu GH, 2022 Biomarkers of aging, Aging Biomarker Consortium; Bao H, Cao J, Chen M, Chen M, Chen W, Chen X, Chen Y, Chen Y, Chen Y, Chen Z, Chhetri JK, Ding Y, Feng J, Guo J, Guo M, He C, Jia Y, Jiang H, Jing Y, Li D, Li J, Li J, Liang Q, Liang R, Liu F, Liu X, Liu Z, Luo O, Lv J, Ma J, Mao K, Nie J, Qiao X, Sun X, Tang X, Wang J, Wang Q, Wang S, Wang X, Wang Y, Wang Y, Wu R, Xia K, Xiao F, Xu L, Xu Y, Yan H, Yang L, Yang R, Yang Y, Ying Y, Zhang L, Zhang W, Zhang W, Zhang X, Zhang Z, Zhou M, Zhou R, Zhu Q, Zhu Z, Cao F, Cao Z, Chan P, Chen C, Chen G, Chen H, Chen J, Ci W, Ding B, Ding Q, Gao F, Han J, Huang K, Ju Z, Kong Q, Li J, Li J, Li X, Liu B, Liu F, Liu L, Liu Q, Liu Q, Liu X, Liu Y, Luo X, Ma S, Ma X, Mao Z, Nie J, Peng Y, Qu J, Ren J, Ren R, Song M, Songyang Z, Sun Y, Sun Y, Tian M, Wang S, Wang S, Wang X, Wang X, Wang Y, Wang Y, Wong CCL, Xiang AP, Xiao Y, Xie Z, Xu D, Ye J, Yue R, Zhang C, Zhang H, Zhang L, Zhang W, Zhang Y, Zhang Y, Zhang Z, Zhao T, Zhao Y, Zhu D, Zou W, Pei G, Liu GH, 2023 Research advances in targeting DNA damage repair to delay aging, Zhang Weina, Chen Yu, Mao Zhiyong, 2023

Areas of Focus

Regulation of aging and genomic stability
Mechanisms of DNA repair and aging
Development of anti-aging and related disease strategies

Publications

Impaired end joining induces cardiac atrophy in a Hutchinson-Gilford progeria mouse model, Chen Y, Huang S, Cui Z, Sun X, Tang Y, Zhang H, Chen Z, Jiang R, Zhang W, Li X, Chen J, Liu B, Jiang Y, Wei K, Mao Z, 2023
Androgen signaling stabilizes genomes to counteract senescence by promoting XRCC4 transcription, Chen Y, Zhen Z, Chen L, Wang H, Wang X, Sun X, Song Z, Wang H, Lin Y, Zhang W, Wu G, Jiang Y, Mao Z, 2023
Nuclear cGAS restricts L1 retrotransposition by promoting TRIM41-mediated ORF2p ubiquitination and degradation, Zhen Z, Chen Y, Wang H, Tang H, Zhang H, Liu H, Jiang Y, Mao Z, 2023
Circadian factors CLOCK and BMAL1 promote nonhomologous end joining and antagonize cellular senescence, Chen Y, Xu X, Chen Z, Chen L, Jiang Y, Mao Z, 2024
A PARP1-BRG1-SIRT1 axis promotes HR repair by reducing nucleosome density at DNA damage sites, Chen Y, Zhang H, Xu Z, Tang H, Geng A, Cai B, Su T, Shi J, Jiang C, Tian X, Seluanov A, Huang J, Wan X, Jiang Y, Gorbunova V, Mao Z, 2019
IDDoR: a novel reporter mouse system for simultaneous and quantitative in vivo analysis of both DNA double-strand break repair pathways, Chen Y, Cui Z, Chen Z, Jiang Y, Mao Z, 2023
The SIRT6 activator MDL-800 improves genomic stability and pluripotency of old murine-derived iPS cells, Chen Y, Chen J, Sun X, Yu J, Qian Z, Wu L, Xu X, Wan X, Jiang Y, Zhang J, Gao S, Mao Z, 2020
A high-throughput small molecule screen identifies farrerol as a potentiator of CRISPR/Cas9-mediated genome editing, Zhang W, Chen Y, Yang J, Zhang J, Yu J, Wang M, Zhao X, Wei K, Wan X, Xu X, Jiang Y, Chen J, Gao S, Mao Z, 2020
Fight to the bitter end: DNA repair and aging, Chen Y, Geng A, Zhang W, Qian Z, Wan X, Jiang Y, Mao Z, 2020
Use of the XRCC2 promoter for in vivo cancer diagnosis and therapy, Chen Y, Li Z, Xu Z, Tang H, Guo W, Sun X, Zhang W, Zhang J, Wan X, Jiang Y, Mao Z, 2018
DNA double-strand break repair and nucleic acid-related immunity, Zhang H, Chen Y, Jiang Y, Mao Z, 2022
The landscape of aging, Cai Y, Song W, Li J, Jing Y, Liang C, Zhang L, Zhang X, Zhang W, Liu B, An Y, Li J, Tang B, Pei S, Wu X, Liu Y, Zhuang C, Ying Y, Dou X, Chen Y, Xiao F, Li D, Yang R, Zhao Y, Wang Y, Wang L, Li Y, Ma S, Wang S, Song X, Ren J, Zhang L, Wang J, Zhang W, Xie Z, Qu J, Wang J, Xiao Y, Tian Y, Wang G, Hu P, Ye J, Sun Y, Mao Z, Kong Q, Liu Q, Zou W, Tian X, Xiao Z, Liu Y, Liu J, Song M, Han J, Liu GH, 2022
Biomarkers of aging, Aging Biomarker Consortium; Bao H, Cao J, Chen M, Chen M, Chen W, Chen X, Chen Y, Chen Y, Chen Y, Chen Z, Chhetri JK, Ding Y, Feng J, Guo J, Guo M, He C, Jia Y, Jiang H, Jing Y, Li D, Li J, Li J, Liang Q, Liang R, Liu F, Liu X, Liu Z, Luo O, Lv J, Ma J, Mao K, Nie J, Qiao X, Sun X, Tang X, Wang J, Wang Q, Wang S, Wang X, Wang Y, Wang Y, Wu R, Xia K, Xiao F, Xu L, Xu Y, Yan H, Yang L, Yang R, Yang Y, Ying Y, Zhang L, Zhang W, Zhang W, Zhang X, Zhang Z, Zhou M, Zhou R, Zhu Q, Zhu Z, Cao F, Cao Z, Chan P, Chen C, Chen G, Chen H, Chen J, Ci W, Ding B, Ding Q, Gao F, Han J, Huang K, Ju Z, Kong Q, Li J, Li J, Li X, Liu B, Liu F, Liu L, Liu Q, Liu Q, Liu X, Liu Y, Luo X, Ma S, Ma X, Mao Z, Nie J, Peng Y, Qu J, Ren J, Ren R, Song M, Songyang Z, Sun Y, Sun Y, Tian M, Wang S, Wang S, Wang X, Wang X, Wang Y, Wang Y, Wong CCL, Xiang AP, Xiao Y, Xie Z, Xu D, Ye J, Yue R, Zhang C, Zhang H, Zhang L, Zhang W, Zhang Y, Zhang Y, Zhang Z, Zhao T, Zhao Y, Zhu D, Zou W, Pei G, Liu GH, 2023
Research advances in targeting DNA damage repair to delay aging, Zhang Weina, Chen Yu, Mao Zhiyong, 2023

Aging Genomic Stability Dna Repair Longevity Gene Regulation Epigenetics Health Span Anti-Aging Disease Intervention Biomedical Research

Yujun Hou - Tongji University

Zhiyong Mao - Tongji University

Fanglin Sun - Tongji University

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