Upload Avatar (500 x 500)
陈御
Life Science
同济大学
上海
Language: 中文, 英语
衰老
基因组稳定性
Dna修复
长寿
基因调控
表观遗传学
健康寿命
抗衰老
疾病干预
生物医学研究
Areas of Focus
- 衰老与基因组稳定性的调控
- DNA修复及衰老机制
- 抗衰老及相关疾病策略的开发
Work Experience
- 2023年至今 - 同济大学 - 助理教授，硕士生导师
- 2022年至2023年 - 同济大学附属医院 - 助理研究员
- 2021年至2022年 - 同济大学附属医院 - 研究实习员
Academic Background & Achievements
- 博士学位
- 主持国家青年项目和上海市科技项目
- 在高影响力期刊上以第一作者和通讯作者发表
Publications
- Impaired end joining induces cardiac atrophy in a Hutchinson-Gilford progeria mouse model, Chen Y, Huang S, Cui Z, Sun X, Tang Y, Zhang H, Chen Z, Jiang R, Zhang W, Li X, Chen J, Liu B, Jiang Y, Wei K, Mao Z, 2023
- Androgen signaling stabilizes genomes to counteract senescence by promoting XRCC4 transcription, Chen Y, Zhen Z, Chen L, Wang H, Wang X, Sun X, Song Z, Wang H, Lin Y, Zhang W, Wu G, Jiang Y, Mao Z, 2023
- Nuclear cGAS restricts L1 retrotransposition by promoting TRIM41-mediated ORF2p ubiquitination and degradation, Zhen Z, Chen Y, Wang H, Tang H, Zhang H, Liu H, Jiang Y, Mao Z, 2023
- Circadian factors CLOCK and BMAL1 promote nonhomologous end joining and antagonize cellular senescence, Chen Y, Xu X, Chen Z, Chen L, Jiang Y, Mao Z, 2024
- A PARP1-BRG1-SIRT1 axis promotes HR repair by reducing nucleosome density at DNA damage sites, Chen Y, Zhang H, Xu Z, Tang H, Geng A, Cai B, Su T, Shi J, Jiang C, Tian X, Seluanov A, Huang J, Wan X, Jiang Y, Gorbunova V, Mao Z, 2019
- IDDoR: a novel reporter mouse system for simultaneous and quantitative in vivo analysis of both DNA double-strand break repair pathways, Chen Y, Cui Z, Chen Z, Jiang Y, Mao Z, 2023
- The SIRT6 activator MDL-800 improves genomic stability and pluripotency of old murine-derived iPS cells, Chen Y, Chen J, Sun X, Yu J, Qian Z, Wu L, Xu X, Wan X, Jiang Y, Zhang J, Gao S, Mao Z, 2020
- A high-throughput small molecule screen identifies farrerol as a potentiator of CRISPR/Cas9-mediated genome editing, Zhang W, Chen Y, Yang J, Zhang J, Yu J, Wang M, Zhao X, Wei K, Wan X, Xu X, Jiang Y, Chen J, Gao S, Mao Z, 2020
- Fight to the bitter end: DNA repair and aging, Chen Y, Geng A, Zhang W, Qian Z, Wan X, Jiang Y, Mao Z, 2020
- Use of the XRCC2 promoter for in vivo cancer diagnosis and therapy, Chen Y, Li Z, Xu Z, Tang H, Guo W, Sun X, Zhang W, Zhang J, Wan X, Jiang Y, Mao Z, 2018
- DNA double-strand break repair and nucleic acid-related immunity, Zhang H, Chen Y, Jiang Y, Mao Z, 2022
- The landscape of aging, Cai Y, Song W, Li J, Jing Y, Liang C, Zhang L, Zhang X, Zhang W, Liu B, An Y, Li J, Tang B, Pei S, Wu X, Liu Y, Zhuang C, Ying Y, Dou X, Chen Y, Xiao F, Li D, Yang R, Zhao Y, Wang Y, Wang L, Li Y, Ma S, Wang S, Song X, Ren J, Zhang L, Wang J, Zhang W, Xie Z, Qu J, Wang J, Xiao Y, Tian Y, Wang G, Hu P, Ye J, Sun Y, Mao Z, Kong Q, Liu Q, Zou W, Tian X, Xiao Z, Liu Y, Liu J, Song M, Han J, Liu GH, 2022
- Biomarkers of aging, Aging Biomarker Consortium; Bao H, Cao J, Chen M, Chen M, Chen W, Chen X, Chen Y, Chen Y, Chen Y, Chen Z, Chhetri JK, Ding Y, Feng J, Guo J, Guo M, He C, Jia Y, Jiang H, Jing Y, Li D, Li J, Li J, Liang Q, Liang R, Liu F, Liu X, Liu Z, Luo O, Lv J, Ma J, Mao K, Nie J, Qiao X, Sun X, Tang X
Awards
- 2023年 - 全国青年优秀生理学学术汇报最佳表达奖
- 2022年 - 上海市医学科技奖
- 2021年 - 同济大学追求卓越奖
- 2022年 - 同济大学优秀博士论文
