Professor | 沈宏杰 | 数字化转型顾问

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Name	沈宏杰
Contact Information	hongjieshen@fudan.edu.cn
Language ability	中文, 英语
Province	上海

Upload Avatar (500 x 500)

Name

沈宏杰

Contact Information

hongjieshen@fudan.edu.cn

Language ability

中文, 英语

Province

上海

University/Lab Affiliation and Title	复旦大学
Faculty	Biomedical Sciences
Academic Background & Achievements	2009.09-2015.07 博士：复旦大学，生物医学研究院 2005.09-2009.07 学士：四川大学，生物技术基地班
Work Experience	2021.01-至今 - 复旦大学，生物医学研究院 - 研究员 2018.08-2020.12 - 复旦大学，生物医学研究院 - 青年研究员 2015.12-2018.07 - 复旦大学，生物医学研究院 - 博士后
Awards	国家自然科学基金优秀青年基金 (2021) 上海市科委青年启明星 (2019)

University/Lab Affiliation and Title

复旦大学

Faculty

Biomedical Sciences

Academic Background & Achievements

2009.09-2015.07 博士：复旦大学，生物医学研究院
2005.09-2009.07 学士：四川大学，生物技术基地班

Work Experience

2021.01-至今 - 复旦大学，生物医学研究院 - 研究员
2018.08-2020.12 - 复旦大学，生物医学研究院 - 青年研究员
2015.12-2018.07 - 复旦大学，生物医学研究院 - 博士后

Awards

国家自然科学基金优秀青年基金 (2021)
上海市科委青年启明星 (2019)

Areas of Focus	RNA及RNA结合蛋白的染色质调控功能新型表观遗传修饰及调控因子的筛选鉴定
Publications	METTL14 regulates chromatin bivalent domains in mouse embryonic stem cells, Mandi Mu, Xinze Li, Li Dong, Jin Wang, Qingqing Cai, Yajun Hu, Duanduan Wang, Peng Zhao, Lei Zhang, Daixuan Zhang, Siyi Cheng, Li Tan, Feizhen Wu, Yujiang Geno Shi, Wenqi Xu, Yang Shi, and Hongjie Shen, 2023 Dynamic control of chromatin-associated m6A methylation regulates nascent RNA synthesis, Wenqi Xu, Chenxi He, Emily G. Kaye, Jiahui Li, Mandi Mu, Geoffrey M. Nelson, Li Dong, Jiahua Wang, Feizhen Wu, Yujiang Geno Shi, Karen Adelman, Fei Lan, Yang Shi and Hongjie Shen, 2022 METTL3 regulates heterochromatin in mouse embryonic stem cells, Wenqi Xu, Jiahui Li, Chenxi He, Jing Wen, Honghui Ma, Bowen Rong, Jianbo Diao, Liyong Wang, Jiahua Wang, Feizhen Wu, Li Tan, Yujiang Geno Shi, Yang Shi, Hongjie Shen, 2021 Binding to m6A RNA promotes YTHDF2-mediated phase separation, Jiahua Wang, Liyong Wang, Jianbo Diao, Yujiang Geno Shi, Yang Shi, Honghui Ma, Hongjie Shen, 2020 DNMT3A reads and connects histone H3K36me2 to DNA methylation, Wenqi Xu, Jiahui Li, Bowen Rong, Bin Zhao, Mei Wang, Ruofei Dai, Qilong Chen, Hang Liu, Zhongkai Gu, Shuxian Liu, Rui Guo, Hongjie Shen, Feizhen Wu, Fei Lan, 2020 When RNA methylation meets DNA methylation, Wenqi Xu, Hongjie Shen, 2022 Suppression of enhancer overactivation by a RACK7-Histone demethylase complex, Hongjie Shen, Wenqi Xu, Rui Guo, Bowen Rong, Lei Gu, Zhentian Wang, Chenxi He, Lijuan Zheng, Xin Hu, Zhen Hu, Zhi-Ming Shao, Pengyuan Yang, Feizhen Wu, Yujiang Geno Shi, Yang Shi, Fei Lan, 2016 Histone lysine demethylases in mammalian embryonic development, Hongjie Shen, Wenqi Xu, Fei Lan, 2017 RACK7 recognizes H3.3G34R mutation to suppress expression of MHC class II complex components and their delivery pathway in pediatric glioblastoma, Fangfang Jiao, Ze Li, Chen He, Wenqi Xu, Gensheng Yang, Tingting Liu, Hongjie Shen, Jiajun Cai, Jamie N Anastas, Ying Mao, Yongchun Yu, Fei Lan, Yujiang Geno Shi, Chris Jones, Yanhui Xu, Suzanne J Baker, Yang Shi, Rui Guo, 2020 The endogenous retrovirus-derived long noncoding RNA TROJAN promotes triple-negative breast cancer progression via ZMYND8 degradation, Xi Jin, Xiao-En Xu, Yi-Zhou Jiang, Yi-Rong Liu, Wei Sun, Ya-Jie Guo, Yi-Xing Ren, Wen-Jia Zuo, Xin Hu, Sheng-Lin Huang, Hong-Jie Shen, Fei Lan, Yun-Fei He, Guo-Hong Hu, Gen-Hong Di, Xiang-Huo He, Da-Qiang Li, Suling Liu, Ke-Da Yu, Zhi-Ming Shao, 2019 Repression of human and mouse brain inflammaging transcriptome by broad gene-body histone hyperacetylation, Hao Cheng, Hongwen Xuan, Christopher D Green, Yixing Han, Na Sun, Hongjie Shen, Joseph McDermott, David A Bennett, Fei Lan, Jing-Dong J Han, 2018 PHF5A Epigenetically Inhibits Apoptosis to Promote Breast Cancer Progression, Yi-Zi Zheng, Meng-Zhu Xue, Hong-Jie Shen, Xiao-Guang Li, Ding Ma, Yue Gong, Yi-Rong Liu, Feng Qiao, Hong-Yan Xie, Bi Lian, Wei-Li Sun, Hai-Yun Zhao, Ling Yao, Wen-Jia Zuo, Da-Qiang Li, Peng Wang, Xin Hu, Zhi-Ming Shao, 2018 Zc3h13 Regulates Nuclear RNA m6A Methylation and Mouse Embryonic Stem Cell Self-Renewal, Jing Wen, Ruitu Lv, Honghui Ma, Hongjie Shen, Chenxi He, Jiahua Wang, Fangfang Jiao, Hang Liu, Pengyuan Yang, Li Tan, Fei Lan, Yujiang Geno Shi, Chuan He, Yang Shi, Jianbo Diao, 2018 ZMYND8 Reads the Dual Histone Mark H3K4me1-H3K14ac to Antagonize the Expression of Metastasis-Linked Genes, Na Li, Yuanyuan Li, Jie Lv, Xiangdong Zheng, Hong Wen, Hongjie Shen, Guangjing Zhu, Tsai-Yu Chen, Shilpa S Dhar, Pu-Yeh Kan, Zhibin Wang, Ramin Shiekhattar

Areas of Focus

RNA及RNA结合蛋白的染色质调控功能
新型表观遗传修饰及调控因子的筛选鉴定

Publications

METTL14 regulates chromatin bivalent domains in mouse embryonic stem cells, Mandi Mu, Xinze Li, Li Dong, Jin Wang, Qingqing Cai, Yajun Hu, Duanduan Wang, Peng Zhao, Lei Zhang, Daixuan Zhang, Siyi Cheng, Li Tan, Feizhen Wu, Yujiang Geno Shi, Wenqi Xu, Yang Shi, and Hongjie Shen, 2023
Dynamic control of chromatin-associated m6A methylation regulates nascent RNA synthesis, Wenqi Xu, Chenxi He, Emily G. Kaye, Jiahui Li, Mandi Mu, Geoffrey M. Nelson, Li Dong, Jiahua Wang, Feizhen Wu, Yujiang Geno Shi, Karen Adelman, Fei Lan, Yang Shi and Hongjie Shen, 2022
METTL3 regulates heterochromatin in mouse embryonic stem cells, Wenqi Xu, Jiahui Li, Chenxi He, Jing Wen, Honghui Ma, Bowen Rong, Jianbo Diao, Liyong Wang, Jiahua Wang, Feizhen Wu, Li Tan, Yujiang Geno Shi, Yang Shi, Hongjie Shen, 2021
Binding to m6A RNA promotes YTHDF2-mediated phase separation, Jiahua Wang, Liyong Wang, Jianbo Diao, Yujiang Geno Shi, Yang Shi, Honghui Ma, Hongjie Shen, 2020
DNMT3A reads and connects histone H3K36me2 to DNA methylation, Wenqi Xu, Jiahui Li, Bowen Rong, Bin Zhao, Mei Wang, Ruofei Dai, Qilong Chen, Hang Liu, Zhongkai Gu, Shuxian Liu, Rui Guo, Hongjie Shen, Feizhen Wu, Fei Lan, 2020
When RNA methylation meets DNA methylation, Wenqi Xu, Hongjie Shen, 2022
Suppression of enhancer overactivation by a RACK7-Histone demethylase complex, Hongjie Shen, Wenqi Xu, Rui Guo, Bowen Rong, Lei Gu, Zhentian Wang, Chenxi He, Lijuan Zheng, Xin Hu, Zhen Hu, Zhi-Ming Shao, Pengyuan Yang, Feizhen Wu, Yujiang Geno Shi, Yang Shi, Fei Lan, 2016
Histone lysine demethylases in mammalian embryonic development, Hongjie Shen, Wenqi Xu, Fei Lan, 2017
RACK7 recognizes H3.3G34R mutation to suppress expression of MHC class II complex components and their delivery pathway in pediatric glioblastoma, Fangfang Jiao, Ze Li, Chen He, Wenqi Xu, Gensheng Yang, Tingting Liu, Hongjie Shen, Jiajun Cai, Jamie N Anastas, Ying Mao, Yongchun Yu, Fei Lan, Yujiang Geno Shi, Chris Jones, Yanhui Xu, Suzanne J Baker, Yang Shi, Rui Guo, 2020
The endogenous retrovirus-derived long noncoding RNA TROJAN promotes triple-negative breast cancer progression via ZMYND8 degradation, Xi Jin, Xiao-En Xu, Yi-Zhou Jiang, Yi-Rong Liu, Wei Sun, Ya-Jie Guo, Yi-Xing Ren, Wen-Jia Zuo, Xin Hu, Sheng-Lin Huang, Hong-Jie Shen, Fei Lan, Yun-Fei He, Guo-Hong Hu, Gen-Hong Di, Xiang-Huo He, Da-Qiang Li, Suling Liu, Ke-Da Yu, Zhi-Ming Shao, 2019
Repression of human and mouse brain inflammaging transcriptome by broad gene-body histone hyperacetylation, Hao Cheng, Hongwen Xuan, Christopher D Green, Yixing Han, Na Sun, Hongjie Shen, Joseph McDermott, David A Bennett, Fei Lan, Jing-Dong J Han, 2018
PHF5A Epigenetically Inhibits Apoptosis to Promote Breast Cancer Progression, Yi-Zi Zheng, Meng-Zhu Xue, Hong-Jie Shen, Xiao-Guang Li, Ding Ma, Yue Gong, Yi-Rong Liu, Feng Qiao, Hong-Yan Xie, Bi Lian, Wei-Li Sun, Hai-Yun Zhao, Ling Yao, Wen-Jia Zuo, Da-Qiang Li, Peng Wang, Xin Hu, Zhi-Ming Shao, 2018
Zc3h13 Regulates Nuclear RNA m6A Methylation and Mouse Embryonic Stem Cell Self-Renewal, Jing Wen, Ruitu Lv, Honghui Ma, Hongjie Shen, Chenxi He, Jiahua Wang, Fangfang Jiao, Hang Liu, Pengyuan Yang, Li Tan, Fei Lan, Yujiang Geno Shi, Chuan He, Yang Shi, Jianbo Diao, 2018
ZMYND8 Reads the Dual Histone Mark H3K4me1-H3K14ac to Antagonize the Expression of Metastasis-Linked Genes, Na Li, Yuanyuan Li, Jie Lv, Xiangdong Zheng, Hong Wen, Hongjie Shen, Guangjing Zhu, Tsai-Yu Chen, Shilpa S Dhar, Pu-Yeh Kan, Zhibin Wang, Ramin Shiekhattar

Rna Rna结合蛋白染色质调控表观遗传学修饰筛选鉴定调控因子生物化学

徐国良 - 复旦大学

蓝斐 - 复旦大学

徐国良 - 复旦大学

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