Professor | 王大成 | 数字化转型顾问

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Name	王大成
Contact Information	dcwang@ibp.ac.cn
Language ability	中文, 英语, 德语
Province	北京

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Name

王大成

Contact Information

dcwang@ibp.ac.cn

Language ability

中文, 英语, 德语

Province

北京

University/Lab Affiliation and Title	中国科学院大学
Faculty	Life Sciences
Academic Background & Achievements	1958-09--1963-08 学士学位: 中国科学技术大学, 生物物理专业
Work Experience	1988-06~1988-12 - 英国约克大学化学系 - Wellcome Trust 研究员 1986-10~现在 - 中国科学院生物物理研究所 - 研究员 1986-06~1990-10 - 中国科学院生物物理研究所 - 副所长 1982-06~1986-10 - 中国科学院生物物理研究所 - 副研究员 1982-04~1984-03 - 德国马克斯-普朗克生物化学研究所 - 洪堡研究员 1978-03~1982-05 - 中国科学院生物物理研究所 - 助理研究员 1963-08~1978-02 - 中国科学院生物物理研究所 - 研究实习员
Awards	高分辨率高精度胰岛素及其去五肽胰岛素晶体结构研究 (1990): 二等奖, 国家级 1.8埃分辨率猪胰岛素晶体结构测定 (1982): 二等奖, 国家级

University/Lab Affiliation and Title

中国科学院大学

Faculty

Life Sciences

Academic Background & Achievements

1958-09--1963-08 学士学位: 中国科学技术大学, 生物物理专业

Work Experience

1988-06~1988-12 - 英国约克大学化学系 - Wellcome Trust 研究员
1986-10~现在 - 中国科学院生物物理研究所 - 研究员
1986-06~1990-10 - 中国科学院生物物理研究所 - 副所长
1982-06~1986-10 - 中国科学院生物物理研究所 - 副研究员
1982-04~1984-03 - 德国马克斯-普朗克生物化学研究所 - 洪堡研究员
1978-03~1982-05 - 中国科学院生物物理研究所 - 助理研究员
1963-08~1978-02 - 中国科学院生物物理研究所 - 研究实习员

Awards

高分辨率高精度胰岛素及其去五肽胰岛素晶体结构研究 (1990): 二等奖, 国家级
1.8埃分辨率猪胰岛素晶体结构测定 (1982): 二等奖, 国家级

Areas of Focus	病原结构生物学蛋白质的结构、功能与分子改造（蛋白质工程）
Publications	Pore-forming activity and structural, 王大成, 2016 Structural Insights into the Molecular Recognition, 王大成, 2015 Structural and Mechanistic Insights into NDM-1 Catalyzed Hydrolysis, 王大成, 2014 Crystal structure of L,D-transpeptidase LdtMt2 in complex, 王大成, 2013 Crystal structures of aprataxin ortholog Hnt3 reveal the structural mechanism for reversal of 5-adenylated DNA, 王大成, 2011 Crystal Structure of HugZ, a Novel Heme Oxygenase from Helicobacter pylori, 王大成, 2011 Crystal Structures of a Populus tomentosa 4-Coumarate:CoA Ligase Shed Light on Its Enzymatic Mechanisms, 王大成, 2010 Structural insights into the recognition mechanism between an antitumor galectin AAL and the Thomsen-Friedenreich antigen, 王大成, 2010 Crystal structures of a novel anti-HIV mannose-binding lectin from Polygonatum cyrtonema Hua with unique ligand-binding property and super-structure, 王大成, 2010 Crystal structure of human programmed cell death 10 complexed with inositol-(1,3,4,5)-tetrakisphosphate: a novel adaptor protein involved in human cerebral cavernous malformation, 王大成, 2010 Structural basis for the tumor cell apoptosis-inducing activity of an antitumor lectin from the edible mushroom Agrocybe aegerita, 王大成, 2009 Crystal structure of DNA gyrase B domain sheds lights on the mechanism for T-segment navigation, 王大成, 2009 Crystal structure of Mabinlin II: a novel structural type of sweet proteins and the main structural basis for its sweetness, 王大成, 2008 Crystal structure of a glutamate/aspartate binding protein complexed with a glutamate molecule: structural basis of ligand specificity at atomic resolution, 王大成, 2008 Structural insights into the enzymatic mechanism of the pathogenic MAPK phosphothreonine lyase, 王大成, 2007

Areas of Focus

病原结构生物学
蛋白质的结构、功能与分子改造（蛋白质工程）

Publications

Pore-forming activity and structural, 王大成, 2016
Structural Insights into the Molecular Recognition, 王大成, 2015
Structural and Mechanistic Insights into NDM-1 Catalyzed Hydrolysis, 王大成, 2014
Crystal structure of L,D-transpeptidase LdtMt2 in complex, 王大成, 2013
Crystal structures of aprataxin ortholog Hnt3 reveal the structural mechanism for reversal of 5-adenylated DNA, 王大成, 2011
Crystal Structure of HugZ, a Novel Heme Oxygenase from Helicobacter pylori, 王大成, 2011
Crystal Structures of a Populus tomentosa 4-Coumarate:CoA Ligase Shed Light on Its Enzymatic Mechanisms, 王大成, 2010
Structural insights into the recognition mechanism between an antitumor galectin AAL and the Thomsen-Friedenreich antigen, 王大成, 2010
Crystal structures of a novel anti-HIV mannose-binding lectin from Polygonatum cyrtonema Hua with unique ligand-binding property and super-structure, 王大成, 2010
Crystal structure of human programmed cell death 10 complexed with inositol-(1,3,4,5)-tetrakisphosphate: a novel adaptor protein involved in human cerebral cavernous malformation, 王大成, 2010
Structural basis for the tumor cell apoptosis-inducing activity of an antitumor lectin from the edible mushroom Agrocybe aegerita, 王大成, 2009
Crystal structure of DNA gyrase B domain sheds lights on the mechanism for T-segment navigation, 王大成, 2009
Crystal structure of Mabinlin II: a novel structural type of sweet proteins and the main structural basis for its sweetness, 王大成, 2008
Crystal structure of a glutamate/aspartate binding protein complexed with a glutamate molecule: structural basis of ligand specificity at atomic resolution, 王大成, 2008
Structural insights into the enzymatic mechanism of the pathogenic MAPK phosphothreonine lyase, 王大成, 2007

病原体结构生物学蛋白质结构分子机制疾病防御蛋白质工程改造功能生物物理

孙方霖 - 同济大学

Area of Focus
表观遗传学 | 分子机制 | 调控 | 异染色质 | 结构 | 功能 | 干细胞 | 衰老 | 网络 | 研究

张梦欢 - 同济大学

俞芳 - 上海师范大学

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