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王大成
Life Science
中国科学院大学
北京
Language: 中文, 英语, 德语
病原体
结构生物学
蛋白质结构
分子机制
疾病
防御
蛋白质工程
改造
功能
生物物理
Areas of Focus
- 病原结构生物学
- 蛋白质的结构、功能与分子改造（蛋白质工程）
Work Experience
- 1988-06~1988-12 - 英国约克大学化学系 - Wellcome Trust 研究员
- 1986-10~现在 - 中国科学院生物物理研究所 - 研究员
- 1986-06~1990-10 - 中国科学院生物物理研究所 - 副所长
- 1982-06~1986-10 - 中国科学院生物物理研究所 - 副研究员
- 1982-04~1984-03 - 德国马克斯-普朗克生物化学研究所 - 洪堡研究员
- 1978-03~1982-05 - 中国科学院生物物理研究所 - 助理研究员
- 1963-08~1978-02 - 中国科学院生物物理研究所 - 研究实习员
Academic Background & Achievements
- 1958-09--1963-08 学士学位: 中国科学技术大学, 生物物理专业
Publications
- Pore-forming activity and structural, 王大成, 2016
- Structural Insights into the Molecular Recognition, 王大成, 2015
- Structural and Mechanistic Insights into NDM-1 Catalyzed Hydrolysis, 王大成, 2014
- Crystal structure of L,D-transpeptidase LdtMt2 in complex, 王大成, 2013
- Crystal structures of aprataxin ortholog Hnt3 reveal the structural mechanism for reversal of 5-adenylated DNA, 王大成, 2011
- Crystal Structure of HugZ, a Novel Heme Oxygenase from Helicobacter pylori, 王大成, 2011
- Crystal Structures of a Populus tomentosa 4-Coumarate:CoA Ligase Shed Light on Its Enzymatic Mechanisms, 王大成, 2010
- Structural insights into the recognition mechanism between an antitumor galectin AAL and the Thomsen-Friedenreich antigen, 王大成, 2010
- Crystal structures of a novel anti-HIV mannose-binding lectin from Polygonatum cyrtonema Hua with unique ligand-binding property and super-structure, 王大成, 2010
- Crystal structure of human programmed cell death 10 complexed with inositol-(1,3,4,5)-tetrakisphosphate: a novel adaptor protein involved in human cerebral cavernous malformation, 王大成, 2010
- Structural basis for the tumor cell apoptosis-inducing activity of an antitumor lectin from the edible mushroom Agrocybe aegerita, 王大成, 2009
- Crystal structure of DNA gyrase B domain sheds lights on the mechanism for T-segment navigation, 王大成, 2009
- Crystal structure of Mabinlin II: a novel structural type of sweet proteins and the main structural basis for its sweetness, 王大成, 2008
- Crystal structure of a glutamate/aspartate binding protein complexed with a glutamate molecule: structural basis of ligand specificity at atomic resolution, 王大成, 2008
- Structural insights into the enzymatic mechanism of the pathogenic MAPK phosphothreonine lyase, 王大成, 2007
Awards
- 高分辨率高精度胰岛素及其去五肽胰岛素晶体结构研究 (1990): 二等奖, 国家级
- 1.8埃分辨率猪胰岛素晶体结构测定 (1982): 二等奖, 国家级
