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王海坤
Life Science
中国科学院大学
上海
Language: 中文, 英语
Tfh细胞
B细胞
分化
转录调节
Foxp1
Cxcr5
Pd-1
Icos
Bcl-6
Il-21
Areas of Focus
- TFH细胞分化的转录调节机制
- 成熟B细胞分化的转录调节研究
Work Experience
- 2014-12~现在 - 中国科学院上海巴斯德研究所 - 研究员
- 2013-08~2014-05 - Wistar研究所（美国） - 助理研究员
- 2009-01~2013-07 - Wistar研究所（美国） - 博士后
- 2007-12~2008-12 - 宾夕法尼亚大学 - 博士后
- 2003-08~2004-08 - 北京华大基因研究所 - 研究助理
Academic Background & Achievements
- 2004-09--2007-07 博士: 北京协和医学院
- 2000-09--2003-07 硕士: 北京大学
- 1996-09--2000-06 学士: 北京大学
Publications
- Foxp1 controls naive CD8+ T cell quiescence by simultaneously repressing key pathways in cellular metabolism and cell cycle progression., The Journal of Immunology, 2016
- The transcription factor Foxp1 is a critical negative regulator of T follicular helper cell differentiation, Nature Immunology, 2014
- Transcription factor Foxp1 exerts essential cell-intrinsic regulation of the quiescence of naive T cells, Nature Immunology, 2011
- Extracellular Calcium Controls Background Current and Neuronal Excitability via an UNC79-UNC80-NALCN Cation Channel Complex, Neuron, 2010
- UNC-80 functions as a scaffold for Src kinase in NALCN channel function, Channels, 2009
- A novel, single, transmembrane protein CATSPERG is associated with CATSPER1 channel protein, Biology of Reproduction, 2009
- Peptide neurotransmitters activate a cation channel complex of NALCN and UNC-80, Nature, 2009
- TAM receptors and the regulation of erythropoiesis in mice, Haematologica, 2009
- Expression patterns and functions of Toll-like receptors in mouse sertoli cells, Endocrinology, 2008
Awards
- The Ching Jer Chern Memorial Award (2012): 研究所
