Areas of Focus
- 干细胞生物学
- 发育生物学
- 基于iPSC技术的体细胞重编程
- 人干细胞全能性及多能性的分子机制
Work Experience
- 现任 - 同济大学生命科学与技术学院，教授，博士生导师
- 现任 - 青年百人计划特聘研究员
- 现任 - 附属东方医院特聘研究员
Academic Background & Achievements
- 2006年 - 学士学位：北京大学生命科学学院
- 2011年 - 博士学位：清华大学北京协和医学院、北京生命科学研究所
- 国家“优秀青年科学基金项目”获得者
- 上海市“扬帆计划”和“晨光计划”项目获得者
Publications
- Cell fate roadmap of human primed-to-naive transition reveals preimplantation cell lineage signatures., Bi Y, Tu Z, Zhou J, Zhu X, Wang H, Gao S*, Wang Y*, 2022
- Bilineage embryo-like structure from EPS cells can produce live mice with tetraploid trophectoderm., Liu K, Xu X, Bai D, Li Y, Zhang Y, Jia Y, Guo M, Han X, Liu Y, Sheng Y, Kou X, Zhao Y, Yin J, Liu S, Chen J, Wang H, Wang Y*, Liu W*, Gao S*, 2022
- Identification of ALPPL2 as a naïve pluripotent state-specific surface protein essential for human naïve pluripotency regulation., Bi Y, Tu Z, Zhang Y, Yang P, Guo M, Zhu X, Zhao C, Zhou J, Wang H, Wang Y*, Gao S*, 2020
- Precise temporal regulation of Dux is important for embryo development., Guo M, Zhang Y, Zhou J, Bi Y, Xu J, Xu C, Kou X, Zhao Y, Li Y, Tu Z, Liu K, Lin J, Yang P*, Gao S*, Wang Y*, 2019
- Unique molecular events during reprogramming of human somatic cells to induced pluripotent stem cells (iPSCs) at naïve state., Wang Y*, Zhao C, Hou Z, Yang Y, Bi Y, Wang H, Zhang Y, Gao S*, 2018
- Epigenetic regulation of somatic cell reprogramming., Wang Y*, Bi Y, Gao S*, 2017
- Human Naive Embryonic Stem Cells: How Full Is the Glass?, Wang Y, Gao S, 2016
- LSD1 corepressor Rcor2 orchestrates neurogenesis in the developing mouse brain., Wang Y, Wu Q, Yang P, Wang C, Liu J, Liu W, Bai Y, Yang Y, Wang H, Gao S, Wang X, 2016
- Naïve iPSCs generated from β-thalassemia fibroblasts allow efficient gene correction with CRISPR/Cas9., Yang Y, Zhang X, Yi L, Hou Z, Chen J, Kou X, Zhao Y, Wang H, Sun X, Jiang C, Wang Y*, Gao S*, 2016
- Enhanced rejuvenation in induced pluripotent stem cell-derived neurons compared with directly converted neurons from an aged mouse., Yang Y, Jiao J, Gao R, Le R, Kou X, Zhao Y, Wang H, Gao S*, Wang Y*, 2015
- Genetic correction of β-thalassemia patient-specific iPS cells and its use in improving hemoglobin production in irradiated SCID mice, Wang Y, Zheng CG, Jiang Y, Zhang J, Chen J, Yao C, Zhao Q, Liu S, Chen K, Du J, Yang Z, Gao S, 2012
- Rcor2 is a subunit of the LSD1 complex that regulates ES cell property and substitutes for Sox2 in reprogramming somatic cells to pluripotency., Yang P, Wang Y, Chen J, Li H, Kang L, Zhang Y, Chen S, Zhu B, Gao S, 2011
- Generation of induced pluripotent stem cells from human beta-thalassemia fibroblast cells., Wang Y, Jiang Y, Liu S, Sun X, Gao S, 2009
Awards
- 国家“优秀青年科学基金项目”获得者
- 上海市“扬帆计划”项目获得者
- 上海市“晨光计划”项目获得者
