Professor | 王译萱 | 数字化转型顾问

Name	王译萱
Contact Information	wangyixuan@tongji.edu.cn
Language ability	中文, 英语
Province	上海

Name

王译萱

Contact Information

wangyixuan@tongji.edu.cn

Language ability

中文, 英语

Province

上海

University/Lab Affiliation and Title	同济大学
Faculty	Life Sciences
Academic Background & Achievements	2006年 - 学士学位：北京大学生命科学学院 2011年 - 博士学位：清华大学北京协和医学院、北京生命科学研究所国家“优秀青年科学基金项目”获得者上海市“扬帆计划”和“晨光计划”项目获得者
Work Experience	现任 - 同济大学生命科学与技术学院，教授，博士生导师现任 - 青年百人计划特聘研究员现任 - 附属东方医院特聘研究员
Awards	国家“优秀青年科学基金项目”获得者上海市“扬帆计划”项目获得者上海市“晨光计划”项目获得者

University/Lab Affiliation and Title

同济大学

Faculty

Life Sciences

Academic Background & Achievements

2006年 - 学士学位：北京大学生命科学学院
2011年 - 博士学位：清华大学北京协和医学院、北京生命科学研究所
国家“优秀青年科学基金项目”获得者
上海市“扬帆计划”和“晨光计划”项目获得者

Work Experience

现任 - 同济大学生命科学与技术学院，教授，博士生导师
现任 - 青年百人计划特聘研究员
现任 - 附属东方医院特聘研究员

Awards

国家“优秀青年科学基金项目”获得者
上海市“扬帆计划”项目获得者
上海市“晨光计划”项目获得者

Areas of Focus	干细胞生物学发育生物学基于iPSC技术的体细胞重编程人干细胞全能性及多能性的分子机制
Publications	Cell fate roadmap of human primed-to-naive transition reveals preimplantation cell lineage signatures., Bi Y, Tu Z, Zhou J, Zhu X, Wang H, Gao S, Wang Y, 2022 Bilineage embryo-like structure from EPS cells can produce live mice with tetraploid trophectoderm., Liu K, Xu X, Bai D, Li Y, Zhang Y, Jia Y, Guo M, Han X, Liu Y, Sheng Y, Kou X, Zhao Y, Yin J, Liu S, Chen J, Wang H, Wang Y, Liu W, Gao S, 2022 Identification of ALPPL2 as a naïve pluripotent state-specific surface protein essential for human naïve pluripotency regulation., Bi Y, Tu Z, Zhang Y, Yang P, Guo M, Zhu X, Zhao C, Zhou J, Wang H, Wang Y, Gao S, 2020 Precise temporal regulation of Dux is important for embryo development., Guo M, Zhang Y, Zhou J, Bi Y, Xu J, Xu C, Kou X, Zhao Y, Li Y, Tu Z, Liu K, Lin J, Yang P, Gao S, Wang Y, 2019 Unique molecular events during reprogramming of human somatic cells to induced pluripotent stem cells (iPSCs) at naïve state., Wang Y, Zhao C, Hou Z, Yang Y, Bi Y, Wang H, Zhang Y, Gao S, 2018 Epigenetic regulation of somatic cell reprogramming., Wang Y, Bi Y, Gao S, 2017 Human Naive Embryonic Stem Cells: How Full Is the Glass?, Wang Y, Gao S, 2016 LSD1 corepressor Rcor2 orchestrates neurogenesis in the developing mouse brain., Wang Y, Wu Q, Yang P, Wang C, Liu J, Liu W, Bai Y, Yang Y, Wang H, Gao S, Wang X, 2016 Naïve iPSCs generated from β-thalassemia fibroblasts allow efficient gene correction with CRISPR/Cas9., Yang Y, Zhang X, Yi L, Hou Z, Chen J, Kou X, Zhao Y, Wang H, Sun X, Jiang C, Wang Y, Gao S, 2016 Enhanced rejuvenation in induced pluripotent stem cell-derived neurons compared with directly converted neurons from an aged mouse., Yang Y, Jiao J, Gao R, Le R, Kou X, Zhao Y, Wang H, Gao S, Wang Y, 2015 Genetic correction of β-thalassemia patient-specific iPS cells and its use in improving hemoglobin production in irradiated SCID mice, Wang Y, Zheng CG, Jiang Y, Zhang J, Chen J, Yao C, Zhao Q, Liu S, Chen K, Du J, Yang Z, Gao S, 2012 Rcor2 is a subunit of the LSD1 complex that regulates ES cell property and substitutes for Sox2 in reprogramming somatic cells to pluripotency., Yang P, Wang Y, Chen J, Li H, Kang L, Zhang Y, Chen S, Zhu B, Gao S, 2011 Generation of induced pluripotent stem cells from human beta-thalassemia fibroblast cells., Wang Y, Jiang Y, Liu S, Sun X, Gao S, 2009

Areas of Focus

干细胞生物学
发育生物学
基于iPSC技术的体细胞重编程
人干细胞全能性及多能性的分子机制

Publications

Cell fate roadmap of human primed-to-naive transition reveals preimplantation cell lineage signatures., Bi Y, Tu Z, Zhou J, Zhu X, Wang H, Gao S*, Wang Y*, 2022
Bilineage embryo-like structure from EPS cells can produce live mice with tetraploid trophectoderm., Liu K, Xu X, Bai D, Li Y, Zhang Y, Jia Y, Guo M, Han X, Liu Y, Sheng Y, Kou X, Zhao Y, Yin J, Liu S, Chen J, Wang H, Wang Y*, Liu W*, Gao S*, 2022
Identification of ALPPL2 as a naïve pluripotent state-specific surface protein essential for human naïve pluripotency regulation., Bi Y, Tu Z, Zhang Y, Yang P, Guo M, Zhu X, Zhao C, Zhou J, Wang H, Wang Y*, Gao S*, 2020
Precise temporal regulation of Dux is important for embryo development., Guo M, Zhang Y, Zhou J, Bi Y, Xu J, Xu C, Kou X, Zhao Y, Li Y, Tu Z, Liu K, Lin J, Yang P*, Gao S*, Wang Y*, 2019
Unique molecular events during reprogramming of human somatic cells to induced pluripotent stem cells (iPSCs) at naïve state., Wang Y*, Zhao C, Hou Z, Yang Y, Bi Y, Wang H, Zhang Y, Gao S*, 2018
Epigenetic regulation of somatic cell reprogramming., Wang Y*, Bi Y, Gao S*, 2017
Human Naive Embryonic Stem Cells: How Full Is the Glass?, Wang Y, Gao S, 2016
LSD1 corepressor Rcor2 orchestrates neurogenesis in the developing mouse brain., Wang Y, Wu Q, Yang P, Wang C, Liu J, Liu W, Bai Y, Yang Y, Wang H, Gao S, Wang X, 2016
Naïve iPSCs generated from β-thalassemia fibroblasts allow efficient gene correction with CRISPR/Cas9., Yang Y, Zhang X, Yi L, Hou Z, Chen J, Kou X, Zhao Y, Wang H, Sun X, Jiang C, Wang Y*, Gao S*, 2016
Enhanced rejuvenation in induced pluripotent stem cell-derived neurons compared with directly converted neurons from an aged mouse., Yang Y, Jiao J, Gao R, Le R, Kou X, Zhao Y, Wang H, Gao S*, Wang Y*, 2015
Genetic correction of β-thalassemia patient-specific iPS cells and its use in improving hemoglobin production in irradiated SCID mice, Wang Y, Zheng CG, Jiang Y, Zhang J, Chen J, Yao C, Zhao Q, Liu S, Chen K, Du J, Yang Z, Gao S, 2012
Rcor2 is a subunit of the LSD1 complex that regulates ES cell property and substitutes for Sox2 in reprogramming somatic cells to pluripotency., Yang P, Wang Y, Chen J, Li H, Kang L, Zhang Y, Chen S, Zhu B, Gao S, 2011
Generation of induced pluripotent stem cells from human beta-thalassemia fibroblast cells., Wang Y, Jiang Y, Liu S, Sun X, Gao S, 2009

干细胞发展 Ipsc 重编程全能性多能性分子生物学基因治疗表观遗传学转录因子

梁德生 - 中南大学

王译萱 - 同济大学

丁秋蓉 - 中国科学院大学

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