Professor | 陈益华 | 数字化转型顾问

Name

陈益华

Contact Information

yhchen@bio.ecnu.edu.cn

Language ability

英语, 汉语

Province

上海

University/Lab Affiliation and Title	华东师范大学
Faculty	Life Sciences
Academic Background & Achievements	1997-2001年：南昌大学化学系，学士 2001-2006年：中国科学院上海药物研究所药物化学，博士，导师：南发俊 2006-2009年：芝加哥伊利诺伊大学药物化学博士后，合作导师：Alan P. Kozikowski
Work Experience	2022.12-至今：华东师范大学，上海市调控生物学重点实验室，教授，博士生导师 2015.12-2022.12：华东师范大学，上海市调控生物学重点实验室，研究员，博士生导师 2009.12-2015.12：华东师范大学，上海市调控生物学重点实验室，副教授
Awards	第十八届中国药学会-施维雅青年药物化学奖（2015年）第六届中国国际“互联网+”大学生创新创业大赛上海赛区优秀指导教师（2020年）

University/Lab Affiliation and Title

华东师范大学

Faculty

Life Sciences

Academic Background & Achievements

Work Experience

Awards

Areas of Focus	化学生物学药物化学靶向关键转录因子的抗肿瘤药学
Publications	Discovery of a Potent and Oral Complex I OXPHOS Inhibitor that Abrogates Tumor Growth and Circumvents MEKi Resistance, Yihua Chen et al., 2023 Discovery of Pyrimidinediamine Derivatives as Potent Methuosis Inducers for the Treatment of Triple-Negative Breast Cancer, Yihua Chen et al., 2023 Discovery of a Highly Potent and Selective MYOF Inhibitor with Improved Water Solubility for the Treatment of Gastric Cancer, Yihua Chen et al., 2023 Current Advances of Small Molecule E3 Ligands for Proteolysis-Targeting Chimeras Design, Yihua Chen et al., 2023 A novel methuosis inducer DZ-514 possesses antitumor activity via activation of ROS-MKK4-p38 axis in triple negative breast cancer, Yihua Chen et al., 2023 Selectively targeting STAT3

Areas of Focus

化学生物学
药物化学
靶向关键转录因子的抗肿瘤药学

Publications

Discovery of a Potent and Oral Complex I OXPHOS Inhibitor that Abrogates Tumor Growth and Circumvents MEKi Resistance, Yihua Chen et al., 2023
Discovery of Pyrimidinediamine Derivatives as Potent Methuosis Inducers for the Treatment of Triple-Negative Breast Cancer, Yihua Chen et al., 2023
Discovery of a Highly Potent and Selective MYOF Inhibitor with Improved Water Solubility for the Treatment of Gastric Cancer, Yihua Chen et al., 2023
Current Advances of Small Molecule E3 Ligands for Proteolysis-Targeting Chimeras Design, Yihua Chen et al., 2023
A novel methuosis inducer DZ-514 possesses antitumor activity via activation of ROS-MKK4-p38 axis in triple negative breast cancer, Yihua Chen et al., 2023
Selectively targeting STAT3

化学生物学药物化学转录因子抗肿瘤药理学药物设计癌症治疗分子抑制剂小分子靶向治疗

陈益华 - 华东师范大学

邓海腾 - 清华大学

李瑞熙 - 南方科技大学

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