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王金勇
wangjinyong@ioz.ac.cn
英语, 中文
北京
中国科学院
Institute of Zoology
  • 2001-2006 博士:浙江大学
  • 成就:国家重点研发计划项目首席科学家
  • 2021年至今 - 中国科学院动物研究所 - 研究员
  • 2012-2021 - 中国科学院广州生物医药与健康研究院 - 研究员
  • 2007-2012 - 美国威斯康星医学院、威斯康星大学麦迪逊医学与公共卫生学院 - 博士后
  • 2006-2007 - 中国农业科学院上海兽医研究所 - 博士后
  • 国家自然科学基金委医学部杰出青年科学基金资助
血液与免疫细胞再生
诱导多能干细胞和基因编辑
  • Mesothelin CAR-engineered NK cells derived from human embryonic stem cells suppress the progression of human ovarian cancer in animals., Liu, Y., M. Zhang, X. Shen, C. Xia, F. Hu, D. Huang, Q. Weng, Q. Zhang, L. Liu, Y. Zhu, L. Wang, J. Hao, M. Zhang, T. Wang and J. Wang, 2024
  • Comparison of seven CD19 CAR designs in engineering NK cells for enhancing anti-tumour activity., Wang, Y., J. Li, Z. Wang, Y. Liu, T. Wang, M. Zhang, C. Xia, F. Zhang, D. Huang, L. Zhang, Y. Zhao, L. Liu, Y. Zhu, H. Qi, X. Zhu, W. Qian, F. Hu and J. Wang, 2024
  • Prolonged generation of multi-lineage blood cells in wild-type animals from pluripotent stem cells., Peng, H., Y. Lin, F. Hu, C. Lv, B. Wu, Q. Weng, L. Liu, C. Xia, X. Liu, Y. Zhao, Q. Zhang, Y. Geng, M. Zhang and J. Wang, 2023
  • Antigen-specific TCR-T cells from Rag2 gene-deleted pluripotent stem cells impede solid tumour growth in a mouse model., Wu, B., Q. Zhang, P. Hong, L. Liu, H. Peng, C. Xia, T. Wang, Y. Wang, Q. Weng, X. Liu, Y. Geng, J. Wang and H. Wu, 2023
  • Identification and characterization of innate lymphoid cells generated from pluripotent stem cells., Xiong, J., Y. Zhao, Y. Lin, L. Chen, Q. Weng, C. Shi, X. Liu, Y. Geng, L. Liu, J. Wang and M. Zhang, 2022
  • Lateral plate mesoderm cell-based organoid system for NK cell regeneration from human pluripotent stem cells., Huang, D., J. Li, F. Hu, C. Xia, Q. Weng, T. Wang, H. Peng, B. Wu, H. Wu, J. Xiong, Y. Lin, Y. Wang, Q. Zhang, X. Liu, L. Liu, X. Zheng, Y. Geng, X. Du, X. Zhu, L. Wang, J. Hao and J. Wang, 2022
  • Hoxb5 reprogrammes murine multipotent blood progenitors into haematopoietic stem cell-like cells., Huang, D., Q. Zhao, M. Zhang, Q. Weng, Q. Zhang, K. Wang, F. Dong, H. Cheng, F. Hu and J. Wang, 2022
  • Co-Expression of Runx1, Hoxa9, Hlf, and Hoxa7 Confers Multi-Lineage Potential on Hematopoietic Progenitors Derived From Pluripotent Stem Cells., Yu, B., B. Wu, P. Hong, H. Peng, M. Zhang, Q. Zhang, L. Liu, X. Liu, Y. Geng, J. Wang and Y. Lan, 2022
  • Regeneration of immunocompetent B lymphopoiesis from pluripotent stem cells guided by transcription factors., Zhang, Q., B. Wu, Q. Weng, F. Hu, Y. Lin, C. Xia, H. Peng, Y. Wang, X. Liu, L. Liu, J. Xiong, Y. Geng, Y. Zhao, M. Zhang, J. Du and J. Wang, 2022
  • Loss of Nupr1 promotes engraftment by tuning the quiescence threshold of hematopoietic stem cell repository via regulating p53-checkpoint pathway., Wang, T., C. Xia, Q. Weng, K. Wang, Y. Dong, S. Hao, F. Dong, X. Liu, L. Liu, Y. Geng, Y. Guan, J. Du, T. Cheng, H. Cheng and J. Wang, 2022
  • Senescent bone marrow microenvironment promotes Nras-mutant leukemia., Zhou, P., C. Xia, T. Wang, Y. Dong, Q. Weng, X. Liu, Y. Geng, J. Wang and J. Du, 2021
  • Pluripotent stem cell-derived CD19-CAR iT cells effectively eradicate B-cell lymphoma in vivo., Lv, C., S. Chen, F. Hu, D. Huang, T. Wang, J. Du, J. Wang and H. Wu, 2021
  • Mesenchymal stem cells suppress leukemia via macrophage-mediated functional restoration of bone marrow microenvironment., Xia, C., T. Wang, H. Cheng, Y. Dong, Q. Weng, G. Sun, P. Zhou, K. Wang, X. Liu, Y. Geng, S. Ma, S. Hao, L. Xu, Y. Guan, J. Du, X. Du, Y. Li, X. Zhu, Y. Shi, S. Xu, D. Wang, T. Cheng and J. Wang, 2020
  • Guiding T lymphopoiesis from pluripotent stem cells by defined transcription factors., Guo, R., F. Hu, Q. Weng, C. Lv, H. Wu, L. Liu, Z. Li, Y. Zeng, Z. Bai, M. Zhang, Y. Liu, X. Liu, C. Xia, T. Wang, P. Zhou, K. Wang, Y. Dong, Y. Luo, X. Zhang, Y. Guan, Y. Geng, J. Du, Y. Li, Y. Lan, J. Chen, B. Liu and J. Wang, 2020
  • T cell regeneration: an update on progress and challenges., Guo, R., H. Wu, J. Du and J. Wang, 2020
  • Hematopoietic lineage-converted T cells carrying tumor-associated antigen-recognizing TCRs effectively kill tumor cells., Hu, F., D. Huang, Y. Luo, P. Zhou, C. Lv, K. Wang, Q. Weng, X. Liu, Y. Guan, Y. Geng, J. Du, J. Chen, J. Wang and H. Wu, 2020
  • Two-step protocol for regeneration of immunocompetent T cells from mouse pluripotent stem cells., Wang, T., C. Lv, F. Hu, L. Liu and J. Wang, 2020
  • NUP98-HOXA10hd fusion protein sustains multi-lineage haematopoiesis of lineage-committed progenitors in transplant setting., Dong, Y., K. Wang, Q. Weng, T. Wang, P. Zhou, X. Liu, Y. Geng, L. Liu, H. Wu, J. Wang and J. Du, 2020
  • Transcription factor Hoxb5 reprograms B cells into functional T lymphocytes., Zhang, M., Y. Dong, F. Hu, D. Yang, Q. Zhao, C. Lv, Y. Wang, C. Xia, Q. Weng, X. Liu, C. Li, P. Zhou, T. Wang, Y. Guan, R. Guo, L. Liu, Y. Geng, H. Wu, J. Du, Z. Hu, S. Xu, J. Chen, A. He, B. Liu, D. Wang, Y. G. Yang and J. Wang, 2018
  • A protocol for generating induced T cells by reprogramming B cells in vivo., Weng, Q., F. Hu, M. Zhang, Y. Dong, C. Lv, Y. Wang, X. Liu and J. Wang, 2018
  • Trim27 confers myeloid hematopoiesis competitiveness by up-regulating myeloid master genes., Wang, T., C. Xia, Y. Dong, X. Chen, J. Wang and J. Du, 2018
  • Pyrimidoindole derivative UM171 enhances derivation of hematopoietic progenitor cells from human pluripotent stem cells., Li, X., C. Xia, T. Wang, L. Liu, Q. Zhao, D. Yang, F. Hu, M. Zhang, K. Huang, Y. Geng, Y. Zheng, Y. Guan, H. Wu, X. Chen, G. Pan, J. Chen, J. Du and J. Wang, 2017
  • Oncogenic NRAS hyper-activates multiple pathways in human cord blood stem/progenitor cells and promotes myelomonocytic proliferation in vivo., Wang, T., C. Li, C. Xia, Y. Dong, D. Yang, Y. Geng, J. Cai, J. Zhang, X. Zhang and J. Wang, 2015
  • OP9-Lhx2 stromal cells facilitate derivation of hematopoietic progenitors both in vitro and in vivo., Chen, X., Q. Zhao, C. Li, Y. Geng, K. Huang, J. Zhang, X. Wang, J. Yang, T. Wang, C. Xia, X. Liu, M. Meng, D. Yang, Y. Zheng, J. Du, X. Zhang, J. Chen, G. Pan and J. Wang, 2015
  • Enforced expression of Hoxa5 in haematopoietic stem cells leads to aberrant erythropoiesis in vivo., Yang, D., X. Zhang, Y. Dong, X. Liu, T. Wang, X. Wang, Y. Geng, S. Fang, Y. Zheng, X. Chen, J. Chen, G. Pan and J. Wang, 2015
  • Nras(G12D/+) promotes leukemogenesis by aberrantly regulating hematopoietic stem cell functions., Wang, J., G. Kong, Y. Liu, J. Du, Y. I. Chang, S. R. Tey, X. Zhang, E. A. Ranheim, M. K. Saba-El-Leil, S. Meloche, A. Damnernsawad, J. Zhang and J. Zhang, 2013
  • Endogenous oncogenic Nras mutation initiates hematopoietic malignancies in a dose- and cell type-dependent manner., Wang, J., Y. Liu, Z. Li, Z. Wang, L. X. Tan, M. J. Ryu, B. Meline, J. Du, K. H. Young, E. Ranheim, Q. Chang and J. Zhang, 2011
  • Endogenous oncogenic Nras mutation promotes aberrant GM-CSF signaling in granulocytic/monocytic precursors in a murine model of chronic myelomonocytic leukemia., Wang, J., Y. Liu, Z. Li, J. Du, M. J. Ryu, P. R. Taylor, M. D. Fleming, K. H. Young, H. Pitot and J. Zhang, 2010
干细胞 造血 免疫细胞 再生 基因编辑 多能性 转录因子 临床转化 细胞疗法 肿瘤治疗

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