Professor | 王文涛 | 数字化转型顾问

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Name	王文涛
Contact Information	wangwt8@mail.sysu.edu.cn
Language ability	中文, 英文
Province	广东

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Name

王文涛

Contact Information

wangwt8@mail.sysu.edu.cn

Language ability

中文, 英文

Province

广东

University/Lab Affiliation and Title	中山大学
Faculty	Life Sciences
Academic Background & Achievements	2014-2017: 中山大学生物化学与分子生物学博士 2011-2014: 中山大学生物化学与分子生物学硕士 2006-2010: 湖北大学双学位成就: 在非编码RNA的疾病发生发展研究中取得重要进展，获得同行认可
Work Experience	2021-至今: 中山大学生命科学学院副教授 2017-2021: 中山大学生命科学学院特聘副研究员

University/Lab Affiliation and Title

中山大学

Faculty

Life Sciences

Academic Background & Achievements

2014-2017: 中山大学生物化学与分子生物学博士
2011-2014: 中山大学生物化学与分子生物学硕士
2006-2010: 湖北大学双学位
成就: 在非编码RNA的疾病发生发展研究中取得重要进展，获得同行认可

Work Experience

2021-至今: 中山大学生命科学学院副教授
2017-2021: 中山大学生命科学学院特聘副研究员

Areas of Focus	RNA功能生物学非编码RNA与疾病
Publications	METTL3 protects METTL14 from STUB1-mediated degradation to maintain m6A homeostasis., Zeng ZC, Pan Q, Sun YM, Huang HJ, Chen XT, Chen TQ, He B, Ye H, Zhu SX, Pu KJ, Fang K, Huang W, Chen YQ, Wang WT., 2023 The snoRNA-like lncRNA LNC-SNO49AB drives leukemia by activating the RNA-editing enzyme ADAR1., Huang W, Sun YM, Pan Q, Fang K, Chen XT, Zeng ZC, Chen TQ, Zhu SX, Huang LB, Luo XQ, Wang WT, Chen YQ., 2022 Chromatin-associated orphan snoRNA regulates DNA damage-mediated differentiation via a non-canonical complex., Han, C, Sun LY, Luo XQ, Pan Q, Sun YM, Zeng ZC, Chen TQ, Huang W, Fang K, Wang WT, Chen YQ., 2022 The oncomicropeptide APPLE promotes hematopoietic malignancy by enhancing translation initiation., Sun LY #, Wang WT #, Han C #, Huang W, Sun YM, Fang K, Zeng ZC, Yang QQ, Pan Q, Chen TQ, Luo XQ, Chen YQ., 2021 The m6A writers regulated by the IL-6/STAT3 inflammatory pathway facilitate cancer cell stemness in cholangiocarcinoma., Ye H#, Chen TQ#, Zeng ZC#, He B, Yang QQ, Pan Q, Chen YQ, Wang WT., 2022 Small nucleolar RNA is potential as a novel player in leukemogenesis and clinical application., Lin LM, Pan Q, Sun YM, Wang WT., 2021 Cis-acting lnc-eRNA SEELA directly binds histone H4 to promote histone recognition and leukemia progression., Fang K#, Huang W#, Sun YM, Chen TQ, Zeng ZC, Yang QQ, Pan Q, Han C, Sun LY, Luo XQ, Wang WT, Chen YQ., 2020 The lncRNA LAMP5-AS1 drives leukemia cell stemness by directly modulating DOT1L methyltransferase activity in MLL leukemia., Wang WT, Chen TQ, Zeng ZC, Pan Q, Huang W, Han C, Fang K, Sun LY, Yang QQ, Wang D, Luo XQ, Sun YM, Chen YQ., 2020 Nuclear export of chimeric mRNAs depends on an lncRNA-triggered autoregulatory loop in blood malignancies., Chen ZH#, Chen TQ#, Zeng ZC, Wang D, Han C, Sun YM, Huang W, Sun LY, Fang K, Chen YQ, Luo XQ, Wang WT., 2020 CircMYBL2, a circRNA from MYBL2, Regulates FLT3 Translation by Recruiting PTBP1 to Promote FLT3-ITD AML Progression., Sun YM#, Wang WT#, Zeng ZC, Chen TQ, Han C, Pan Q, Huang W, Fang K, Sun LY, Zhou YF, Luo XQ, Luo C, Du X, Chen YQ., 2019 Activation of the lysosome-associated membrane protein LAMP5 by DOT1L serves as a bodyguard for MLL fusion oncoproteins to evade degradation in leukemia., Wang WT#, Han C#, Sun YM#, Chen ZH, Fang K, Huang W, Sun LY, Zeng ZC, Luo XQ, Chen YQ., 2019 Noncoding RNAs in cancer therapy resistance and targeted drug development., Wang WT#, Han C#, Sun YM, Chen TQ, Chen YQ., 2019 circRNA circAF4 functions as an oncogene to regulate MLL-AF4 fusion protein expression and inhibit MLL leukemia progression., Huang W#, Fang K#, Chen TQ, Zeng ZC, Sun YM, Han C, Sun LY, Chen ZH, Yang QQ, Pan Q, Luo XQ, Wang WT, Chen YQ., 2019 LncRNA ANRIL regulates AML development through modulating the glucose metabolism pathway of AdipoR1/AMPK/SIRT1., Sun LY#, Li XJ#, Sun YM, Huang W, Fang K, Han C, Chen ZH, Luo XQ, Chen YQ, Wang WT., 2018 Global identification and characterization of lncRNAs that control inflammation in malignant cholangiocytes., Han BW#, Ye H#, Wei PP, He B, Han C, Chen ZH, Chen YQ, Wang WT., 2018

Areas of Focus

RNA功能生物学
非编码RNA与疾病

Publications

METTL3 protects METTL14 from STUB1-mediated degradation to maintain m6A homeostasis., Zeng ZC, Pan Q, Sun YM, Huang HJ, Chen XT, Chen TQ, He B, Ye H, Zhu SX, Pu KJ, Fang K, Huang W, Chen YQ, Wang WT*., 2023
The snoRNA-like lncRNA LNC-SNO49AB drives leukemia by activating the RNA-editing enzyme ADAR1., Huang W, Sun YM, Pan Q, Fang K, Chen XT, Zeng ZC, Chen TQ, Zhu SX, Huang LB, Luo XQ, Wang WT*, Chen YQ*., 2022
Chromatin-associated orphan snoRNA regulates DNA damage-mediated differentiation via a non-canonical complex., Han, C, Sun LY, Luo XQ, Pan Q, Sun YM, Zeng ZC, Chen TQ, Huang W, Fang K, Wang WT*, Chen YQ*., 2022
The oncomicropeptide APPLE promotes hematopoietic malignancy by enhancing translation initiation., Sun LY #, Wang WT #, Han C #, Huang W, Sun YM, Fang K, Zeng ZC, Yang QQ, Pan Q, Chen TQ, Luo XQ, Chen YQ*., 2021
The m6A writers regulated by the IL-6/STAT3 inflammatory pathway facilitate cancer cell stemness in cholangiocarcinoma., Ye H#, Chen TQ#, Zeng ZC#, He B, Yang QQ, Pan Q, Chen YQ, Wang WT*., 2022
Small nucleolar RNA is potential as a novel player in leukemogenesis and clinical application., Lin LM, Pan Q, Sun YM, Wang WT*., 2021
Cis-acting lnc-eRNA SEELA directly binds histone H4 to promote histone recognition and leukemia progression., Fang K#, Huang W#, Sun YM, Chen TQ, Zeng ZC, Yang QQ, Pan Q, Han C, Sun LY, Luo XQ, Wang WT*, Chen YQ*., 2020
The lncRNA LAMP5-AS1 drives leukemia cell stemness by directly modulating DOT1L methyltransferase activity in MLL leukemia., Wang WT, Chen TQ, Zeng ZC, Pan Q, Huang W, Han C, Fang K, Sun LY, Yang QQ, Wang D, Luo XQ, Sun YM*, Chen YQ*., 2020
Nuclear export of chimeric mRNAs depends on an lncRNA-triggered autoregulatory loop in blood malignancies., Chen ZH#, Chen TQ#, Zeng ZC, Wang D, Han C, Sun YM, Huang W, Sun LY, Fang K, Chen YQ, Luo XQ, Wang WT*., 2020
CircMYBL2, a circRNA from MYBL2, Regulates FLT3 Translation by Recruiting PTBP1 to Promote FLT3-ITD AML Progression., Sun YM#, Wang WT#, Zeng ZC, Chen TQ, Han C, Pan Q, Huang W, Fang K, Sun LY, Zhou YF, Luo XQ, Luo C, Du X, Chen YQ*., 2019
Activation of the lysosome-associated membrane protein LAMP5 by DOT1L serves as a bodyguard for MLL fusion oncoproteins to evade degradation in leukemia., Wang WT#, Han C#, Sun YM#, Chen ZH, Fang K, Huang W, Sun LY, Zeng ZC, Luo XQ, Chen YQ*., 2019
Noncoding RNAs in cancer therapy resistance and targeted drug development., Wang WT#, Han C#, Sun YM, Chen TQ, Chen YQ*., 2019
circRNA circAF4 functions as an oncogene to regulate MLL-AF4 fusion protein expression and inhibit MLL leukemia progression., Huang W#, Fang K#, Chen TQ, Zeng ZC, Sun YM, Han C, Sun LY, Chen ZH, Yang QQ, Pan Q, Luo XQ, Wang WT*, Chen YQ*., 2019
LncRNA ANRIL regulates AML development through modulating the glucose metabolism pathway of AdipoR1/AMPK/SIRT1., Sun LY#, Li XJ#, Sun YM, Huang W, Fang K, Han C, Chen ZH, Luo XQ, Chen YQ*, Wang WT*., 2018
Global identification and characterization of lncRNAs that control inflammation in malignant cholangiocytes., Han BW#, Ye H#, Wei PP, He B, Han C, Chen ZH, Chen YQ*, Wang WT*., 2018

Rna 生物学功能非编码疾病白血病 Ncrna 研究生物化学分子

戚正武 - 同济大学

钱洁 - 同济大学

孙方霖 - 同济大学

Area of Focus
表观遗传学 | 分子机制 | 调控 | 异染色质 | 结构 | 功能 | 干细胞 | 衰老 | 网络 | 研究

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