Professor | 曹骎 | 数字化转型顾问

	Upload Avatar (500 x 500)
Name	曹骎
Contact Information	caoqin@sjtu.edu.cn
Language ability	英语, 中文
Province	上海

Upload Avatar (500 x 500)

Name

曹骎

Contact Information

caoqin@sjtu.edu.cn

Language ability

英语, 中文

Province

上海

University/Lab Affiliation and Title	上海交通大学
Faculty	Bio-X Research Institute
Academic Background & Achievements	2004-2008 学士: 上海交通大学 2008-2013 博士: 北京大学入选上海市海外高层次人才引进计划国家级海外青年人才项目科技创新2030重大项目青年首席科学家
Work Experience	2013-2019 - 加州大学洛杉矶分校 - 博士后 2019-2021 - 加州大学洛杉矶分校 - 助理研究员

University/Lab Affiliation and Title

上海交通大学

Faculty

Bio-X Research Institute

Academic Background & Achievements

2004-2008 学士: 上海交通大学
2008-2013 博士: 北京大学
入选上海市海外高层次人才引进计划
国家级海外青年人才项目
科技创新2030重大项目青年首席科学家

Work Experience

2013-2019 - 加州大学洛杉矶分校 - 博士后
2019-2021 - 加州大学洛杉矶分校 - 助理研究员

Areas of Focus	基于冷冻电镜的病理性或功能性蛋白纤维结构解析基于结构的抑制剂设计阿尔兹海默症早期诊断方案开发
Publications	Molecular architecture of the assembly of Bacillus spore coat protein GerQ revealed by cryo-EM, Cheng, Y., Kreutzberger, M., Han, J., Egelman, E., and Cao, Q., 2024 Serine peptidase Vpr forms enzymatically active fibrils outside Bacillus bacteria revealed by cryo-EM, Cheng, Y., Han, J., Song, M., Zhang S., Cao, Q., 2023 Amyloid fibrils in disease FTLD-TDP are composed of TMEM106B not TDP-43, Jiang, Y. X., Cao, Q., Sawaya, M. R., Abskharon, R., Ge, P., DeTure, M., Dickson, D. W., Fu, J. Y., Loo, R. R. O., Loo, J. A., and Eisenberg, D. S., 2022 Cryo-EM structures of hIAPP fibrils seeded by patient-extracted fibrils reveal new polymorphs and conserved fibril cores, Cao, Q., Boyer, D. R., Sawaya, M. R., Abskharon, R., Saelices, L., Nguyen, B.A., Lu J., Murry, K.A., Kandeel, F., and Eisenberg, D.S., 2021 The inhibition of cellular toxicity of amyloid-beta by dissociated transthyretin., Cao, Q., Anderson, D.H., Liang, W., Chou, J., and Saelices, L., 2020 Cryo-EM structure and inhibitor design of human IAPP (amylin) fibrils., Cao, Q., Boyer, D. R., Sawaya, M. R., Ge, P., and Eisenberg, D.S., 2020 Cryo-EM structures of four polymorphic TDP-43 amyloid cores., Cao, Q., Boyer, D. R., Sawaya, M. R., Ge, P., and Eisenberg, D.S., 2019 Inhibiting amyloid-β cytotoxicity through its interaction with the cell surface receptor LilrB2 by structure-based design., Cao, Q., Shin, W. S., Chan, H., Vuong, C. K., Dubois, B., Li, B., Murray, K. A., Sawaya, M. R., Feigon, J., Black, D. L., Eisenberg, D. S., and Jiang, L., 2018 Atomic structures of TDP-43 LCD segments and insights into reversible or pathogenic aggregation., Guenther, E. L., Cao, Q., Trinh, H., Lu, J., Sawaya, M. R., Cascio, D., Boyer, D. R., Rodriguez, J. A., Hughes, M. P., and Eisenberg, D. S., 2018 The regulatory mechanism of the caspase 6 pro-domain revealed by crystal structure and biochemical assays., Cao, Q., Wang, X.-J., Li, L.-F., and Su, X.-D., 2014 Inhibitory mechanism of caspase-6 phosphorylation revealed by crystal structures, molecular dynamics simulations, and biochemical assays., Cao, Q., Wang, X.-J., Liu, C.-W., Liu, D.-F., Li, L.-F., Gao, Y.-Q., and Su, X.-D., 2012 Molecular structure of an amyloid fibril formed by FUS low-complexity domain, Sun, Y., Zhang, S., Hu, J., Tao, Y., Xia, W., Gu, J., Li, Y., Cao, Q., Li, D., and Liu, C., 2022 The hereditary mutation G51D unlocks a distinct fibril strain transmissible to wild-type α-synuclein, Sun, Y., Long, H., Xia, W., Wang, K., Zhang, X., Sun, B., Cao, Q., Zhang, Y., Dai, B., Li, D., and Liu, C., 2021 The cryo-EM structure of the fibril-forming low-complexity domain of hnRNPA2 reveals distinct differences from pathogenic amyloid and shows how mutation converts it to the pathogenic form., Lu, J., Cao, Q., Hughes, M.P., Sawaya, M.R., Boyer, D.R., Cascio, D., and Eisenberg., D.S., 2020 Amyloid β-protein oligomers promote the uptake of tau fibril seeds potentiating intracellular tau aggregation., Shin, W.S., Di, J., Cao, Q., Li, B., Seidler, P.M., Murray, K.M., Bitan, G., and Jiang, L., 2019 Structure-based peptide inhibitor design of amyloid-aggregation., Lu J., Cao, Q., Wang, C., Zheng, J., Luo, F., Xie, J., Li, Y., Ma, X., He, L., Eisenberg, D. S., Nowick, J., Jiang, L., and Li, D., 2019 Activation and Regulation of Caspase-6 and Its Role in Neurodegenerative Diseases., Wang, X.-J., Cao, Q., Zhang, Y., and Su, X.-D., 2015 Crystal structures of human caspase 6 reveal a new mechanism for intramolecular cleavage self-activation., Wang, X.-J., Cao, Q., Liu, X., Wang, K.-T., Mi, W., Zhang, Y, Li, L.-F., LeBlanc A. C., and Su, X.-D., 2010

Areas of Focus

基于冷冻电镜的病理性或功能性蛋白纤维结构解析
基于结构的抑制剂设计
阿尔兹海默症早期诊断方案开发

Publications

Molecular architecture of the assembly of Bacillus spore coat protein GerQ revealed by cryo-EM, Cheng, Y., Kreutzberger, M., Han, J., Egelman, E., and Cao, Q., 2024
Serine peptidase Vpr forms enzymatically active fibrils outside Bacillus bacteria revealed by cryo-EM, Cheng, Y., Han, J., Song, M., Zhang S., Cao, Q., 2023
Amyloid fibrils in disease FTLD-TDP are composed of TMEM106B not TDP-43, Jiang, Y. X., Cao, Q., Sawaya, M. R., Abskharon, R., Ge, P., DeTure, M., Dickson, D. W., Fu, J. Y., Loo, R. R. O., Loo, J. A., and Eisenberg, D. S., 2022
Cryo-EM structures of hIAPP fibrils seeded by patient-extracted fibrils reveal new polymorphs and conserved fibril cores, Cao, Q., Boyer, D. R., Sawaya, M. R., Abskharon, R., Saelices, L., Nguyen, B.A., Lu J., Murry, K.A., Kandeel, F., and Eisenberg, D.S., 2021
The inhibition of cellular toxicity of amyloid-beta by dissociated transthyretin., Cao, Q., Anderson, D.H., Liang, W., Chou, J., and Saelices, L., 2020
Cryo-EM structure and inhibitor design of human IAPP (amylin) fibrils., Cao, Q., Boyer, D. R., Sawaya, M. R., Ge, P., and Eisenberg, D.S., 2020
Cryo-EM structures of four polymorphic TDP-43 amyloid cores., Cao, Q., Boyer, D. R., Sawaya, M. R., Ge, P., and Eisenberg, D.S., 2019
Inhibiting amyloid-β cytotoxicity through its interaction with the cell surface receptor LilrB2 by structure-based design., Cao, Q., Shin, W. S., Chan, H., Vuong, C. K., Dubois, B., Li, B., Murray, K. A., Sawaya, M. R., Feigon, J., Black, D. L., Eisenberg, D. S., and Jiang, L., 2018
Atomic structures of TDP-43 LCD segments and insights into reversible or pathogenic aggregation., Guenther, E. L., Cao, Q., Trinh, H., Lu, J., Sawaya, M. R., Cascio, D., Boyer, D. R., Rodriguez, J. A., Hughes, M. P., and Eisenberg, D. S., 2018
The regulatory mechanism of the caspase 6 pro-domain revealed by crystal structure and biochemical assays., Cao, Q., Wang, X.-J., Li, L.-F., and Su, X.-D., 2014
Inhibitory mechanism of caspase-6 phosphorylation revealed by crystal structures, molecular dynamics simulations, and biochemical assays., Cao, Q., Wang, X.-J., Liu, C.-W., Liu, D.-F., Li, L.-F., Gao, Y.-Q., and Su, X.-D., 2012
Molecular structure of an amyloid fibril formed by FUS low-complexity domain, Sun, Y., Zhang, S., Hu, J., Tao, Y., Xia, W., Gu, J., Li, Y., Cao, Q., Li, D., and Liu, C., 2022
The hereditary mutation G51D unlocks a distinct fibril strain transmissible to wild-type α-synuclein, Sun, Y., Long, H., Xia, W., Wang, K., Zhang, X., Sun, B., Cao, Q., Zhang, Y., Dai, B., Li, D., and Liu, C., 2021
The cryo-EM structure of the fibril-forming low-complexity domain of hnRNPA2 reveals distinct differences from pathogenic amyloid and shows how mutation converts it to the pathogenic form., Lu, J., Cao, Q., Hughes, M.P., Sawaya, M.R., Boyer, D.R., Cascio, D., and Eisenberg., D.S., 2020
Amyloid β-protein oligomers promote the uptake of tau fibril seeds potentiating intracellular tau aggregation., Shin, W.S., Di, J., Cao, Q., Li, B., Seidler, P.M., Murray, K.M., Bitan, G., and Jiang, L., 2019
Structure-based peptide inhibitor design of amyloid-aggregation., Lu J., Cao, Q., Wang, C., Zheng, J., Luo, F., Xie, J., Li, Y., Ma, X., He, L., Eisenberg, D. S., Nowick, J., Jiang, L., and Li, D., 2019
Activation and Regulation of Caspase-6 and Its Role in Neurodegenerative Diseases., Wang, X.-J., Cao, Q., Zhang, Y., and Su, X.-D., 2015
Crystal structures of human caspase 6 reveal a new mechanism for intramolecular cleavage self-activation., Wang, X.-J., Cao, Q., Liu, X., Wang, K.-T., Mi, W., Zhang, Y, Li, L.-F., LeBlanc A. C., and Su, X.-D., 2010

冷冻电镜蛋白纤维病理性功能性结构解析抑制剂设计阿尔兹海默症诊断生物化学分子生物学

万春玲 - 上海交通大学

View All

Personal Information

Academic Information

Research

联系我们

还未创建账户?

Personal Information

Academic Information

Research

联系我们