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李丹
Bio-X Research Institute
上海交通大学
上海
Language: 中文, 英文
蛋白
相分离
相变
生物物理
生物化学
细胞生物学
神经退行性
疾病
淀粉样
聚集
Areas of Focus
- 蛋白相分离和相变
- 神经退行性疾病
Academic Background & Achievements
- 1998-2002 学士: 吉林大学
- 2002-2008 博士: 北京大学
- 2008-2013 博士后: 加州大学洛杉矶分校(UCLA)/霍华德休斯医学院
Publications
- Parkinson’s disease associated mutation E46K of α-synuclein triggers the formation of a distinct fibril structure., Zhao, K., Li, Y., Liu, Z., Long, H., Zhao, C., Luo, F., Sun, Y., Tao, Y., Su, X.-D., Li, D., Li, X., Liu, C., 2020
- Structural basis of the interplay between α-synuclein and Tau in regulating pathological amyloid aggregation., Lu J, Zhang S, Ma X, Jia C, Liu Z, Huang C, Liu C, Li D., 2020
- Nicotinamide mononucleotide adenylyltransferase uses its NAD+ substrate-binding site to chaperone phosphorylated Tau., Ma X, Zhu Y, Lu J, Xie J, Li C, Shin WS, Qiang J, Liu J, Dou S, Xiao Y, Wang C, Jia C, Long H, Yang J, Fang Y, Jiang L, Zhang Y, Zhang S, Zhai RG, Liu C, Li D., 2020
- Cryo-EM structure of full-length α-synuclein amyloid fibril with Parkinson’s disease familial A53T mutation., Sun, Y., Hou, S., Zhao, K., Long, H., Liu, Z., Gao, J., Zhang, Y., Su, X. D., Li, D., Liu, C., 2020
- Different regions of synaptic vesicle membrane regulate VAMP2 conformation for the SNARE assembly., Wang, C., Tu, J., Zhang, S., Cai, B., Liu, Z., Hou, S., Zhong, Q., Hu, X., Liu, W., Li, G., Liu, Z., He, L., Diao, J., Zhu, Z. J., Li, D., Liu, C., 2020
- Hsp27 chaperones FUS phase separation under the modulation of stress-induced phosphorylation., Liu, Z., Zhang S., Gu, J., Tong, Y., Li, Y., Gui, X., Long, H., Wang, C., Zhao, C., Lu, J., Lin, H., Li, Y., Liu, Z., Li, D., Liu, C., 2020
- Structural Diversity of Amyloid Fibrils and Advances in Their Structure Determination., Li, D., Liu, C., 2020
- Different heat shock proteins bind α-synuclein with distinct mechanisms and synergistically prevent its amyloid aggregation., Jia, C., Ma, X., Liu, Z., Gu, J., Zhang, X., Li, D., Zhang, S., 2019
- Structural basis for reversible amyloids of hnRNPA1 elucidates their role in stress granule assembly., Gui, X., Luo, F., Li, YC, Zhou, H., Qin,Z., Liu, ZY, Gu, JG, Xie, MY, Zhao, K., Dai, B., Shin, WS, He, JH, He, L., Jiang, L., Zhao, ML, Sun, B., Li, XM, Liu, C., Li, D., 2019
- Structure-Based Peptide Inhibitor Design of Amyloid-b Aggregation., Lu, J., Cao, Q., Wang, C., Zheng, J., Luo, F., Xie, J., Li, Y., Ma, X., He, L., Eisenberg, D., Nowick, J., Jiang, L., Li, D., 2019
- Amyloid fibril structure of alpha-synuclein determined by cryo-electron microscopy., Li, Y., Zhao, C., Luo, F., Liu, Z., Gui, X., Luo, Z., Zhang, X., Li, D., Liu, C., Li, X., 2018
- Better together: a hybrid amyloid signals necroptosis., Li, D., Liu, C., 2018
- Atomic structures of FUS LC domain segments reveal bases for reversible amyloid fibril formation., Luo, F., Gui, X., Zhou, H., Gu, J., Li, Y., Liu, X., Zhao, M., Li, D., Li, X., Liu, C., 2018
