Professor | 赵秀丽 | 数字化转型顾问

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Name	赵秀丽
Contact Information	xiulizhao@ibms.pumc.edu.cn
Language ability	中文, 英语
Province	北京

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Name

赵秀丽

Contact Information

xiulizhao@ibms.pumc.edu.cn

Language ability

中文, 英语

Province

北京

University/Lab Affiliation and Title	北京协和医学院
Faculty	Basic Medical Sciences
Academic Background & Achievements	1991 - 生物学学士学位：河北师范大学 2003 - 遗传学硕士学位：东南大学医学院 2006 - 医学遗传学博士学位：北京协和医学院 2008-2010 - 博士后研究：约翰霍普金斯大学医学院成就：发现HOXD13的Q50R致病突变与并指（趾）V型相关
Work Experience	1999-2000 - 讲师：河北北方学院医学院 2006至今 - 教授：北京协和医学院基础医学研究所 2008-2010 - 博士后研究员：约翰霍普金斯大学医学院
Awards	中华医学科学二等奖国家教育部高校自然科学一等奖

University/Lab Affiliation and Title

北京协和医学院

Faculty

Basic Medical Sciences

Academic Background & Achievements

1991 - 生物学学士学位：河北师范大学
2003 - 遗传学硕士学位：东南大学医学院
2006 - 医学遗传学博士学位：北京协和医学院
2008-2010 - 博士后研究：约翰霍普金斯大学医学院
成就：发现HOXD13的Q50R致病突变与并指（趾）V型相关

Work Experience

1999-2000 - 讲师：河北北方学院医学院
2006至今 - 教授：北京协和医学院基础医学研究所
2008-2010 - 博士后研究员：约翰霍普金斯大学医学院

Awards

中华医学科学二等奖
国家教育部高校自然科学一等奖

Areas of Focus	单基因遗传性骨病致病基因诊断技术和致病突变谱的研究利用人诱导干细胞和动物模型进行人类单基因遗传病的基因治疗研究
Publications	A long noncoding RNA contributes to neuropathic pain by silencing Kcna2 in primary afferent neurons, Zhao X#, Tang Z, Zhang H, Atianjoh FE, Zhao JY, Liang L, Wang W, Guan X, Kao SC, Tiwari V, Gao YJ, Hoffman PN, Cui H, Li M, Dong X, Tao YX, 2013 Morphine tolerance and hyperalgesia mediated through mu opioid receptor-triggered activation of the mammalian target of rapamycin complex 1 pathway in dorsal horn neurons, Xu J, Zhao J, Zhao X#, LigonsD, Tiwari V, Atianjoh FE, Liang L, Zang W, Njoku D, Raja SN, Yaster M, Tao YX, 2014 Mutations in HOXD13 underlie syndactyly type V and a novel brachydactyly-syndactyly syndrome, Zhao X#, Sun M, Zhao J, Leyva JA, Zhu H, Yang W, Zeng X, Ao Y, Liu Q, Liu G, Lo WH, Jabs EW, Amzel LM, Shan X, Zhang X, 2007 A novel deletion in TNNI2 causes distal arthrogryposis in a large Chinese family with marked variability of expression, Jiang M, Zhao X#, Han WT, Bian CY, Li XF, Wang G, Ao Y, Li YQ, Yi DX, Zhe Y, Lo HY Wilson, Zhang X, Li JX, 2006 Absence of μ opioid receptor mRNA expression in astrocytes and microglia of rat spinal cord, Kao SC, Zhao X, Lee CY, Atianjoh FE, Gauda EB, Yaster M, Tao YX, 2012 Screening for AIP gene mutations in a Han Chinese pituitary adenoma cohort followed by LOH analysis, Cai F, Zhang YD, Zhao X, et al., 2013 Spinal cord protein interacting with C kinase 1 is required for the maintenance of complete Freund's adjuvant-induced inflammatory pain but not for incision-induced post-operative pain, Atianjoh FE, Yaster M, Zhao X, Takamiya K, Xia J, Gauda EB, Huganir RL, Tao YX, 2010 Expression and distribution of mTOR, p70S6K, 4E-BP1, and their phosphorylated counterparts in rat dorsal root ganglion and spinal cord dorsal horn, Xu JT, Zhao X, Yaster M, Tao YX, 2010 Three novel mutations of the EDA gene in Chinese patients with X-linked hypohidrotic ectodermal dysplasia, Zhao J, Hua R, Zhao X, Meng Y, Ao Y, Liu Q, Shang D, Sun M, Lo WH, Zhang X, 2008 一个角膜-鱼鳞病-耳聋综合征家系的致病突变分析, 李璐璐，李媛，林蔚，赵秀丽, 2017 应用PCR-HRM技术进行FGFR3热点突变的快速诊断, 李闪，汪涵，苏华，高劲松，赵秀丽, 2017 成骨不全症家系COL1A1/2的大片段缺失突变分析, 汪涵, 赵秀丽, 任秀智, 肖继芳, 张学, 2016 遗传性乳光牙本质家系致病基因突变的鉴定, 刘彦山，黄颖之，赵秀丽，张学, 2016 成骨不全症的COL1A1/2突变谱和基因诊断研究, 赵秀丽#，肖继芳，汪涵，任秀智，高劲松，吴易阳，卢超霞，孙悦，张学, 2015

Areas of Focus

单基因遗传性骨病致病基因诊断技术和致病突变谱的研究
利用人诱导干细胞和动物模型进行人类单基因遗传病的基因治疗研究

Publications

A long noncoding RNA contributes to neuropathic pain by silencing Kcna2 in primary afferent neurons, Zhao X#, Tang Z, Zhang H, Atianjoh FE, Zhao JY, Liang L, Wang W, Guan X, Kao SC, Tiwari V, Gao YJ, Hoffman PN, Cui H, Li M, Dong X, Tao YX, 2013
Morphine tolerance and hyperalgesia mediated through mu opioid receptor-triggered activation of the mammalian target of rapamycin complex 1 pathway in dorsal horn neurons, Xu J, Zhao J, Zhao X#, LigonsD, Tiwari V, Atianjoh FE, Liang L, Zang W, Njoku D, Raja SN, Yaster M, Tao YX, 2014
Mutations in HOXD13 underlie syndactyly type V and a novel brachydactyly-syndactyly syndrome, Zhao X#, Sun M, Zhao J, Leyva JA, Zhu H, Yang W, Zeng X, Ao Y, Liu Q, Liu G, Lo WH, Jabs EW, Amzel LM, Shan X, Zhang X, 2007
A novel deletion in TNNI2 causes distal arthrogryposis in a large Chinese family with marked variability of expression, Jiang M, Zhao X#, Han WT, Bian CY, Li XF, Wang G, Ao Y, Li YQ, Yi DX, Zhe Y, Lo HY Wilson, Zhang X, Li JX, 2006
Absence of μ opioid receptor mRNA expression in astrocytes and microglia of rat spinal cord, Kao SC, Zhao X, Lee CY, Atianjoh FE, Gauda EB, Yaster M, Tao YX, 2012
Screening for AIP gene mutations in a Han Chinese pituitary adenoma cohort followed by LOH analysis, Cai F, Zhang YD, Zhao X, et al., 2013
Spinal cord protein interacting with C kinase 1 is required for the maintenance of complete Freund's adjuvant-induced inflammatory pain but not for incision-induced post-operative pain, Atianjoh FE, Yaster M, Zhao X, Takamiya K, Xia J, Gauda EB, Huganir RL, Tao YX, 2010
Expression and distribution of mTOR, p70S6K, 4E-BP1, and their phosphorylated counterparts in rat dorsal root ganglion and spinal cord dorsal horn, Xu JT, Zhao X, Yaster M, Tao YX, 2010
Three novel mutations of the EDA gene in Chinese patients with X-linked hypohidrotic ectodermal dysplasia, Zhao J, Hua R, Zhao X, Meng Y, Ao Y, Liu Q, Shang D, Sun M, Lo WH, Zhang X, 2008
一个角膜-鱼鳞病-耳聋综合征家系的致病突变分析, 李璐璐，李媛，林蔚，赵秀丽*, 2017
应用PCR-HRM技术进行FGFR3热点突变的快速诊断, 李闪，汪涵，苏华，高劲松，赵秀丽*, 2017
成骨不全症家系COL1A1/2的大片段缺失突变分析, 汪涵, 赵秀丽*, 任秀智, 肖继芳, 张学, 2016
遗传性乳光牙本质家系致病基因突变的鉴定, 刘彦山，黄颖之，赵秀丽*，张学, 2016
成骨不全症的COL1A1/2突变谱和基因诊断研究, 赵秀丽#，肖继芳，汪涵，任秀智，高劲松，吴易阳，卢超霞，孙悦，张学, 2015

遗传学骨病突变诊断基因治疗干细胞动物模型单基因遗传性研究

徐军 - 北京大学

孙祺 - 北京大学

毛泽斌 - 北京大学

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