Professor | 张杰 | 数字化转型顾问

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Name	张杰
Contact Information	njiezhang@xmu.edu.cn
Language ability	中文, 英语
Province	福建

Upload Avatar (500 x 500)

Name

张杰

Contact Information

njiezhang@xmu.edu.cn

Language ability

中文, 英语

Province

福建

University/Lab Affiliation and Title	厦门大学
Faculty	Medical
Academic Background & Achievements	1997-2001 学士：四川大学生命科学学院 2001-2006 博士：中科院生物物理研究所国家杰出青年科学基金获得者国家优秀青年科学基金获得者教育部新世纪优秀人才支持计划入选者
Work Experience	2006-2011 博士后研究助理：美国新泽西州立大学 2011-至今特聘教授：厦门大学医学院
Awards	国家杰出青年科学基金国家优秀青年科学基金福建省杰出青年基金

University/Lab Affiliation and Title

厦门大学

Faculty

Medical

Academic Background & Achievements

1997-2001 学士：四川大学生命科学学院
2001-2006 博士：中科院生物物理研究所
国家杰出青年科学基金获得者
国家优秀青年科学基金获得者
教育部新世纪优秀人才支持计划入选者

Work Experience

2006-2011 博士后研究助理：美国新泽西州立大学
2011-至今特聘教授：厦门大学医学院

Awards

国家杰出青年科学基金
国家优秀青年科学基金
福建省杰出青年基金

Areas of Focus	重大脑疾病如阿尔茨海默病、抑郁症、自闭症、术后认知功能障碍的致病机理和药物开发
Publications	年龄相关的高胰岛素血症导致神经元胰岛素抵抗和细胞周期诱导的衰老。, Chow HM, Shi Meng, Cheng A, Gao Y, Chen G, Song X, So RWL, Jie Zhang, Karl Herrup, 2019 Menin缺乏通过调节星形胶质细胞介导的神经炎症导致小鼠抑郁样行为。, Lige Leng, Kai Zhuang, Zeyue Liu, Changquan Huang, Yuehong Gao, Guimiao Chen, Hui Lin, Yu Hu, Di Wu, Meng Shi, Wenting Xie, Hao Sun, Zhicheng Shao, Huifang Li, Kunkun Zhang, Wei Mo, Timothy Y. Huang, Maoqiang Xue, Zengqiang Yuan, Xia Zhang, Guojun Bu, Huaxi Xu, Qi Xu,* and Jie Zhang, 2018 神经元特异性menin缺失通过调节p35表达导致突触功能障碍和认知障碍。, Kai Zhuang, Changquan Huang, Lige Leng, Honghua Zheng, Yuehong Gao, Guimiao Chen, Zhilin Ji, Hao Sun, Yu Hu, Di Wu, Meng Shi, Huifang Li, Yingjun Zhao, Yunwu Zhang, Maoqiang Xue, Guojun Bu, Timothy Y. Huang, Huaxi Xu, Jie Zhang, 2018 CDK5依赖的BAG3降解调节突触蛋白周转。, Jiechao Zhou, Hei-Man Chow, Yan Liu, Di Wu, Meng Shi, Jieyin Li, Lei Wen, Yuehong Gao, Guimiao Chen, Kai Zhuang, Hui Lin, Guanyun Zhang, Wenting Xie, Huifang Li, Lige Leng, Mengdan Wang, Naizhen Zheng, Hao Sun, Yingjun Zhao, Yunwu Zhang, Maoqiang Xue, Timothy Y. Huang, Guojun Bu, Huaxi Xu, Zengqiang Yuan, Karl Herrup, Jie Zhang, 2018 细胞周期依赖性激酶5介导的氯化物细胞内通道4磷酸化促进氧化应激诱导的神经元死亡。, Guo D, Xie W, Xiong P, Li H, Wang S, Chen G, Gao Y, Zhou J, Zhang Y, Bu G, Maoqiang Xue, M, Jie Zhang, 2018 CDK5介导的TPX2磷酸化和稳定性促进肝细胞肿瘤发生。, Wang F, Zhao W, Gao Y, Zhou J, Li H, Zhang G, Guo D, Xie C, Li J, Zhenyu Yin, Zhang Jie, 2019 Cdk5介导的FOXO1亚细胞定位在神经元死亡中的作用。, Jiechao Zhou, Huifang Li, Xiaoping Li, Guanyun Zhang, Yaqiong Niu, Zengqiang Yuan, Karl Herrup, YunWu Zhang, Guojun Bu, Huaxi Xu, Jie Zhang, 2015 CDK5激活蛋白p25优先结合并激活GSK3β。, Chow HM, Guo D, Zhou JC, Zhang GY, Li HF, Herrup Karl, Zhang Jie, 2014 细胞周期依赖性激酶5在胃癌中减少，其核积累抑制胃肿瘤发生。, Longlong Cao, Jiechao Zhou, Junrong Zhang, Sijin Wu, Xintao Yang, Xin Zhao, Huifang Li, Ming Luo, Qian Yu, Jianwei Xie, Ping Li, Xiaoqing Hu, Chaohui Zheng, Guojun Bu, Yun-wu Zhang, Huaxi Xu, Yongliang Yang, Changming Huang, Jie Zhang, 2015 基于结构生物信息学的EGFR抑制剂Gefitinib作为BACE潜在先导化合物的鉴定。, Mingshan Niu, Jin Hu, Sijin Wu, Xiaoe Zhang, Huaxi Xu, Yunwu Zhang, Jie Zhang, Yongliang Yang , 2014 将3,3'-二羟基异芪转化为羟基苯乙烯：寻找具有更高抗增殖活性和细胞选择性的白藜芦醇类似物。, Kang YF, Yan WJ, Zhou TW, Dai F, Li XZ, Bao XZ, Du YT, Yuan CH, Wang HB, Ren XR, Liu Q, Jin XL, Zhou B, Zhang Jie, 2014 Cdk5水平在神经元细胞周期中振荡：Cdh1泛素化触发S期的蛋白酶体依赖性降解。, Zhang Jie, Li Huifang, Zhou Tingwen, Zhou Jiechao, Herrup Karl, 2012 核质Cdk5参与神经元细胞周期和后有丝分裂神经元的死亡。, Zhang Jie & Herrup K, 2011 Cdk5通过破坏E2F1-DP1复合物抑制神经元细胞周期。, Zhang Jie, Huifang Li, Herrup Karl, 2010 Cdk5在神经细胞中的核定位依赖于p27：对细胞周期抑制和caspase-3激活的影响。, Zhang Jie, Huifang Li, Herrup Karl, 2010 Cdk5的核定位是神经元后有丝分裂状态的关键决定因素。, Zhang Jie, Cicero, S.A., Wang, L., Romito-Digiacomo, R.R., Yang, Y. and Herrup, K, 2008 Cdk5和神经元细胞周期的非催化停滞。, Zhang Jie, Herrup Karl, 2008 在小鼠阿尔茨海默病模型中解剖尼古丁介导的神经保护信号通路。, Liu Qiang, Zhang Jie, Zhu Hua, Qin Chuan, Chen Qi and Zhao Baolu Zhao, 2007 尼古丁通过调节金属稳态减轻β-淀粉样蛋白诱导的神经毒性。, Zhang Jie, Liu Qiang, Liu Nian-Qing, Li Fu-Liang, Chen Qi, Qin Chuan, Zhu Hua, Huang Yu-Ying, He Wei, Zhao Bao-Lu, 2006

Areas of Focus

重大脑疾病如阿尔茨海默病、抑郁症、自闭症、术后认知功能障碍的致病机理和药物开发

Publications

年龄相关的高胰岛素血症导致神经元胰岛素抵抗和细胞周期诱导的衰老。, Chow HM, Shi Meng, Cheng A, Gao Y, Chen G, Song X, So RWL, Jie Zhang*, Karl Herrup*, 2019
Menin缺乏通过调节星形胶质细胞介导的神经炎症导致小鼠抑郁样行为。, Lige Leng, Kai Zhuang, Zeyue Liu, Changquan Huang, Yuehong Gao, Guimiao Chen, Hui Lin, Yu Hu, Di Wu, Meng Shi, Wenting Xie, Hao Sun, Zhicheng Shao, Huifang Li, Kunkun Zhang, Wei Mo, Timothy Y. Huang, Maoqiang Xue, Zengqiang Yuan, Xia Zhang, Guojun Bu, Huaxi Xu, Qi Xu,* and Jie Zhang*, 2018
神经元特异性menin缺失通过调节p35表达导致突触功能障碍和认知障碍。, Kai Zhuang, Changquan Huang, Lige Leng, Honghua Zheng, Yuehong Gao, Guimiao Chen, Zhilin Ji, Hao Sun, Yu Hu, Di Wu, Meng Shi, Huifang Li, Yingjun Zhao, Yunwu Zhang, Maoqiang Xue, Guojun Bu, Timothy Y. Huang, Huaxi Xu, Jie Zhang*, 2018
CDK5依赖的BAG3降解调节突触蛋白周转。, Jiechao Zhou, Hei-Man Chow, Yan Liu, Di Wu, Meng Shi, Jieyin Li, Lei Wen, Yuehong Gao, Guimiao Chen, Kai Zhuang, Hui Lin, Guanyun Zhang, Wenting Xie, Huifang Li, Lige Leng, Mengdan Wang, Naizhen Zheng, Hao Sun, Yingjun Zhao, Yunwu Zhang, Maoqiang Xue, Timothy Y. Huang, Guojun Bu, Huaxi Xu, Zengqiang Yuan, Karl Herrup, Jie Zhang*, 2018
细胞周期依赖性激酶5介导的氯化物细胞内通道4磷酸化促进氧化应激诱导的神经元死亡。, Guo D, Xie W, Xiong P, Li H, Wang S, Chen G, Gao Y, Zhou J, Zhang Y, Bu G, Maoqiang Xue*, M, Jie Zhang*, 2018
CDK5介导的TPX2磷酸化和稳定性促进肝细胞肿瘤发生。, Wang F, Zhao W, Gao Y, Zhou J, Li H, Zhang G, Guo D, Xie C, Li J, Zhenyu Yin*, Zhang Jie*, 2019
Cdk5介导的FOXO1亚细胞定位在神经元死亡中的作用。, Jiechao Zhou, Huifang Li, Xiaoping Li, Guanyun Zhang, Yaqiong Niu, Zengqiang Yuan, Karl Herrup, YunWu Zhang, Guojun Bu, Huaxi Xu, Jie Zhang*, 2015
CDK5激活蛋白p25优先结合并激活GSK3β。, Chow HM, Guo D, Zhou JC, Zhang GY, Li HF, Herrup Karl, Zhang Jie*, 2014
细胞周期依赖性激酶5在胃癌中减少，其核积累抑制胃肿瘤发生。, Longlong Cao, Jiechao Zhou, Junrong Zhang, Sijin Wu, Xintao Yang, Xin Zhao, Huifang Li, Ming Luo, Qian Yu, Jianwei Xie, Ping Li, Xiaoqing Hu, Chaohui Zheng, Guojun Bu, Yun-wu Zhang, Huaxi Xu*, Yongliang Yang*, Changming Huang*, Jie Zhang*, 2015
基于结构生物信息学的EGFR抑制剂Gefitinib作为BACE潜在先导化合物的鉴定。, Mingshan Niu, Jin Hu, Sijin Wu, Xiaoe Zhang, Huaxi Xu, Yunwu Zhang, Jie Zhang*, Yongliang Yang *, 2014
将3,3'-二羟基异芪转化为羟基苯乙烯：寻找具有更高抗增殖活性和细胞选择性的白藜芦醇类似物。, Kang YF, Yan WJ, Zhou TW, Dai F, Li XZ, Bao XZ, Du YT, Yuan CH, Wang HB, Ren XR, Liu Q, Jin XL, Zhou B*, Zhang Jie*, 2014
Cdk5水平在神经元细胞周期中振荡：Cdh1泛素化触发S期的蛋白酶体依赖性降解。, Zhang Jie*, Li Huifang, Zhou Tingwen, Zhou Jiechao, Herrup Karl, 2012
核质Cdk5参与神经元细胞周期和后有丝分裂神经元的死亡。, Zhang Jie & Herrup K, 2011
Cdk5通过破坏E2F1-DP1复合物抑制神经元细胞周期。, Zhang Jie, Huifang Li, Herrup Karl, 2010
Cdk5在神经细胞中的核定位依赖于p27：对细胞周期抑制和caspase-3激活的影响。, Zhang Jie, Huifang Li, Herrup Karl, 2010
Cdk5的核定位是神经元后有丝分裂状态的关键决定因素。, Zhang Jie, Cicero, S.A., Wang, L., Romito-Digiacomo, R.R., Yang, Y. and Herrup, K, 2008
Cdk5和神经元细胞周期的非催化停滞。, Zhang Jie, Herrup Karl, 2008
在小鼠阿尔茨海默病模型中解剖尼古丁介导的神经保护信号通路。, Liu Qiang*, Zhang Jie*, Zhu Hua, Qin Chuan, Chen Qi and Zhao Baolu Zhao, 2007
尼古丁通过调节金属稳态减轻β-淀粉样蛋白诱导的神经毒性。, Zhang Jie, Liu Qiang, Liu Nian-Qing, Li Fu-Liang, Chen Qi, Qin Chuan, Zhu Hua, Huang Yu-Ying, He Wei, Zhao Bao-Lu, 2006

阿尔茨海默病抑郁症自闭症术后认知功能障碍致病机理药物开发神经生物学神经科学神经炎症遗传风险因素

胡海岚 - 浙江大学

李晓明 - 浙江大学

包爱民 - 浙江大学

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