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孔双博
Medical School
厦门大学
福建
Language: 中文, 英语
胚胎着床
分子机制
子宫接受态
囊胚激活
激素受体
子宫内膜分化
转基因模型
基因敲除
生化方法
研究论文
Areas of Focus
- 胚胎着床的分子调控
Work Experience
- 2022.11-至今 - 厦门大学医学院 - 教授
- 2021.08-2022.10 - 厦门大学医学院 - 副教授
- 2016.06-2021.07 - 厦门大学医学院 - 助理教授
- 2014.07-2016.05 - 中国科学院动物研究所 - 博士后
Academic Background & Achievements
- 2004-2008 理学学士 生物科学专业: 西北大学
- 2008-2014 博士 发育生物学: 中国科学院大学
- 国家优秀青年科学基金获得者
- 厦门大学南强青年拔尖A类人才
Publications
- Menin directs regionalized decidual transformation through epigenetically setting PTX3 to balance FGF and BMP signaling., Liu, M., et al., 2022
- P38alpha MAPK is a gatekeeper of uterine progesterone responsiveness at peri-implantation via Ube3c-mediated PGR degradation., Tang, Y., et al., 2022
- SOX4 facilitates PGR protein stability and FOXO1 expression conducive for human endometrial decidualization., Huang, P., et al., 2022
- CDC42 governs normal oviduct multiciliogenesis through activating AKT to ensure timely embryo transport., Jiang, R., et al., 2022
- Maternal anxiety affects embryo implantation via impairing adrenergic receptor signaling in decidual cells., Wu, J., et al., 2022
- Shp2 in uterine stromal cells critically regulates on time embryo implantation and stromal decidualization by multiple pathways during early pregnancy., Cheng, J., et al., 2022
- Adgrg1 is a new transcriptional target of Hand1 during trophoblast giant cell differentiation., Yu, Y., et al., 2022
- Ablation of the miR-465 Cluster Causes a Skewed Sex Ratio in Mice., Wang, Z., et al., 2022
- MAX deficiency impairs human endometrial decidualization through down-regulating OSR2 in women with recurrent spontaneous abortion., Ma, W., et al., 2022
- Human Endometrial Organoids: Recent Research Progress and Potential Applications., Lou, L., et al., 2022
- Sequential activation of uterine epithelial IGF1R by stromal IGF1 and embryonic IGF2 directs normal uterine preparation for embryo implantation., Zhou, C., et al., 2021
- Uterine Notch2 facilitates pregnancy recognition and corpus luteum maintenance via upregulating decidual Prl8a2., Bao, H., et al., 2021
- Single-cell RNA-seq revealed diverse cell types in the mouse placenta at mid-gestation., Zhou, X., et al., 2021
- Psychological Stress and Functional Endometrial Disorders: Update of Mechanism Insights., Wu, J.X., S. Lin, and S.B. Kong, 2021
- HOXA10 co-factor MEIS1 is required for the decidualization in human endometrial stromal cell., Xu, Y., et al., 2020
- Osteoprotegerin interacts with syndecan-1 to promote human endometrial stromal decidualization by decreasing Akt phosphorylation., Jiang, Y., et al., 2020
- Hyperactivated Wnt-beta-catenin signaling in the absence of sFRP1 and sFRP5 disrupts trophoblast differentiation through repression of Ascl2., Bao, H., et al., 2020
- EHD1 impairs decidualization by regulating the Wnt4/beta-catenin signaling pathway in recurrent implantation failure., Zhou, Q., et al., 2019
- Circadian gene PER1 senses progesterone signal during human endometrial decidualization., Zhang, Y., et al., 2019
- Implantation initiation of self-assembled embryo-like structures generated using three types of mouse blastocyst-derived stem cells., Zhang, S., et al., 2019
- An exaggerated epinephrine-adrenergic receptor signaling impairs uterine decidualization in mice., Wu, J., et al., 2019
- Biallelic mutations in Sperm flagellum 2 cause human multiple morphological abnormalities of the sperm flagella (MMAF) phenotype., Sha, Y., et al., 2019
- Spatiotemporal coordination of trophoblast and allantoic Rbpj signaling directs normal placental morphogenesis., Lu, J., et al., 2019
- DNAH2 is a novel candidate gene associated with multiple morphological abnormalities of the sperm flagella., Li, Y., et al., 2019
- The role of tyrosine phosphatase Shp2 in spermatogonial differentiation and spermatocyte meiosis., Li, Y., et al., 2019
- Epigenetic control of embryo-uterine crosstalk at peri-implantation., Kong, S., et al., 2019
- Traditional Chinese medicine Dingkun Pill facilitates uterine receptivity for implantation in micedagger., Huang, L., et al., 2019
- Blastocyst activation engenders transcriptome reprogram affecting X-chromosome reactivation and inflammatory trigger of implantation., He, B., et al., 2019
- Ubiquitin-specific protease 7 (USP7) is essential for endometrial stromal cell decidualization in mice., Gao, Y., et al., 2019
- Polycomb subunit BMI1 determines uterine progesterone responsiveness essential for normal embryo implantation., Xin, Q., et al., 2018
- Generation of Elf5-Cre knockin mouse strain for trophoblast-specific gene manipulation., Kong, S., et al., 2018
- Transcript analysis identifies differential uterine gene expression profile beyond the normal implantation window in mice., Xin, Q., et al., 2017
- Nuclear Shp2 directs normal embryo implantation via facilitating the ERalpha tyrosine phosphorylation by the Src kinase., Ran, H., et al., 2017
- PR-Set7 deficiency limits uterine epithelial population growth hampering postnatal gland formation in mice., Cui, T., et al., 2017
- Spatiotemporal expression of endogenous opioid processing enzymes in mouse uterus at peri-implantation., Wu, W., et al., 2016
- Uterine RAC1 via Pak1-ERM signaling directs normal luminal epithelial integrity conducive to on-time embryo implantation in mice., Tu, Z., et al., 2016
- MCM2 mediates progesterone-induced endometrial stromal cell proliferation and differentiation in mice., Kong, S., et al., 2016
- Uterine Prx2 restrains decidual differentiation through inhibiting lipolysis in mice., Jiang, Y., et al., 2016
- Systemic morphine treatment derails normal uterine receptivity, leading to embryo implantation failure in mice., Tang, X., et al., 2015
- FoxM1 Directs STAT3 Expression Essential for Human Endometrial Stromal Decidualization., Jiang, Y., et al., 2015
- Rbbp7 Is Required for Uterine Stromal Decidualization in Mice., He, H., et al., 2015
- Uterine Rbpj is required for embryonic-uterine orientation and decidual remodeling via Notch pathway-independent and -dependent mechanisms., Zhang, S., et al., 2014
- Integral proteomic analysis of blastocysts reveals key molecular machinery governing embryonic diapause and reactivation for implantation in mice., Fu, Z., et al., 2014
- Preimplantation mouse embryo is a target for opioid ligand-receptor signaling., Chen, Y., et al., 2014
- Physiological and molecular determinants of embryo implantation., Zhang, S., et al., 2013
- Deciphering the molecular basis of uterine receptivity., Zhang, S., et al., 2013
- A positive feedback loop involving Gcm1 and Fzd5 directs chorionic branching morphogenesis in the placenta., Lu, J., et al., 2013
- Determinants of uterine aging: lessons from rodent models., Kong, S., et al., 2012
Awards
- 国家优秀青年科学基金获得者
