Areas of Focus
- 造血或血细胞形成
- 巨噬细胞和树突状细胞发展和组织特化
- 免疫细胞在器官衰老和组织再生过程的作用
- 免疫细胞在黑色素细胞瘤发生及转移中的作用
Work Experience
- 2022- 讲席教授, 南方科技大学
- 2012-2022 教授, 香港科技大学
- 2007-2012 副教授, 香港科技大学
- 2002-2007 课题组组长, 新加坡分子与细胞生物学研究所
- 1999-2002 课题组组长, 新加坡农业生物学院
- 1997-1999 博士后, 斯坦福大学
Academic Background & Achievements
- 1981-1986 医学学士:第一军医大学
- 1992-1997 博士:洛克菲勒大学
- 斯坦福医学院博士后研究
Publications
- Cross-tissue single-cell transcriptome profiling reveals macrophage and dendritic cell heterogeneity in zebrafish, Zhou QX, Zhao CL, Yang ZY, Qu R, Li YB, Fan YN, Tang JL, Wen ZL, 2023
- Metaphocytes are IL-22BP producing cells regulated by ETS transcription factor Spic and essential for zebrafish barrier immunity, Zhao CL, Li YB, Tang JL, Zhou QX, Lin X, Wen ZL, 2023
- Cell competition for neuron-derived trophic factor controls the turnover and lifespan of microglia, Yu T, Kuang HY, Huang Y, Wu XH, Wang JZ, Wen ZL, 2023
- Mafba and Mafbb regulate microglial colonization of zebrafish brain via controlling chemotaxis receptor expression, Lou L, Yu T, Dai YM, Zhao SZ, Feng SC, Xu J, Wen ZL, 2022
- Hemogenic and aortic endothelium arise from a common hemogenic angioblast precursor and are specified by the Etv2 dosage, Zhao SZ, Feng SC, Tian Y, Wen ZL, 2022
- Two phenotypically and functionally distinct microglial populations in adult zebrafish, Wu ST, Nguyen TML, Pan HR, Hassan S, Dai YM, Xu J, Wen ZL, 2020
- Endoderm-derived myeloid-like metaphocytes in zebrafish gill mediate soluble antigen-induced immunity, Lin X, Zhou QX, Lin GZ, Zhao CL, Wen ZL, 2020
- An ectoderm-derived myeloid-like cell population functions as antigen transporters for Langerhans cells in zebrafish epidermis, Lin X, Zhou QX, Zhao CL, Lin GZ, Xu J, Wen ZL, 2019
- Il34-Csf1r pathway regulates the migration and colonization of microglial precursors, Wu ST, Xue RT, Hassan SL, Nguyen TML, Wang TN, Pan HR, Liu QF, Xu J, Zhang WQ, Wen ZL, 2018
- Distinct regulatory networks control the development of macrophages of different origins in zebrafish, Yu T, Guo WL, Tian Y, Xu J, Chen JH, Li L, Wen ZL, 2017
- The first wave of T lymphopoiesis in zebrafish arises from aorta endothelium independent of hematopoietic stem cells, Tian Y, Xu J, Feng SC, He SC, Zhao SZ, Zhu L, Jin W, Dai YM, Luo LF, Qu JY, Wen ZL, 2017
- Microglia colonization of developing zebrafish midbrain is promoted by apoptotic neuron and lysophosphatidylcholine, Xu J, Wang TN, Wu Y, Jin W, Wen ZL, 2016
- Temporal-spatial resolution fate mapping reveals distinct origins for embryonic and adult microglia in zebrafish, Xu J, Zhu L, He SC, Wu Y, Jin W, Yu T, Qu JY, Wen ZL, 2015
Awards
- 2019: 香港裘槎基金会优秀学者奖
- 2011: 香港科技大学理学院优秀科研奖
- 1998: Helen Hay Whitney Foundation博士后奖学金
- 1997: American Cancer Society博士后奖学金