Professor | 瞿旭东 | 数字化转型顾问

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Name	瞿旭东
Contact Information	quxd19@sjtu.edu.cn
Language ability	中文, 英语
Province	上海

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Name

瞿旭东

Contact Information

quxd19@sjtu.edu.cn

Language ability

中文, 英语

Province

上海

University/Lab Affiliation and Title	上海交通大学
Faculty	Life Sciences
Academic Background & Achievements	2002-2007: 博士, 中国科学院上海有机化学研究所 1998-2002: 本科, 华东师范大学化学系
Work Experience	2020.09-至今: 教授, 上海交通大学生命科学技术学院 2012.01-2020.08: 教授, 武汉大学药学院 2011.01-2011.12: 副研究员, 中科院上海有机化学研究所 2008.11-2010.12: 助理研究员, 中科院上海有机化学研究所 2007.09-2008.10: 博士后, 美国麻省理工学院化学系
Awards	2023: 国家技术标准创新基地（乳业）金鬲创新项目奖 2023: 中央高校优秀青年团队带头人 2023: 第九届中国国际互联网加大学生创新创业大赛上海赛区铜奖 2022: 上海市优秀学术带头人 2013: 国家自然科学基金委优秀青年科学基金计划 2012: 教育部新世纪优秀人才支持计划 2012: 武汉大学珞珈学者特聘教授

University/Lab Affiliation and Title

上海交通大学

Faculty

Life Sciences

Academic Background & Achievements

2002-2007: 博士, 中国科学院上海有机化学研究所
1998-2002: 本科, 华东师范大学化学系

Work Experience

2020.09-至今: 教授, 上海交通大学生命科学技术学院
2012.01-2020.08: 教授, 武汉大学药学院
2011.01-2011.12: 副研究员, 中科院上海有机化学研究所
2008.11-2010.12: 助理研究员, 中科院上海有机化学研究所
2007.09-2008.10: 博士后, 美国麻省理工学院化学系

Awards

2023: 国家技术标准创新基地（乳业）金鬲创新项目奖
2023: 中央高校优秀青年团队带头人
2023: 第九届中国国际互联网加大学生创新创业大赛上海赛区铜奖
2022: 上海市优秀学术带头人
2013: 国家自然科学基金委优秀青年科学基金计划
2012: 教育部新世纪优秀人才支持计划
2012: 武汉大学珞珈学者特聘教授

Areas of Focus	天然产物的定向生物合成
Publications	An unusual aromatase/cyclase programs the formation of the phenyldimethylanthrone framework in anthrabenzoxocinones and fasamycin, Kai Jiang, Xu Chen, Xiaoli Yan, Zixin Deng, Shunkun Luo, Xudong Qu, 2024 Engineering the substrate specificity of a P450 dimerase enables the collective biosynthesis of heterodimeric tryptophan-containing diketopiperazines, Chenghai Sun, Bao-Di Ma, Guangjun Li, Wenya Tian, Lu Yang, Haidong Peng, Zhi Lin, Zixin Deng, Xu-Dong Kong, Xudong Qu, 2023 A large conserved family of small-molecule carboxyl methyltransferases identified from microorganisms, Zhi Lin, Zhiwei Hu, Linjun Zhou, Benben Liu, Xiaowei Huang, Zixin Deng, Xudong Qu, 2023 A chemoenzymatic approach to C14-functionalized steroids, Fuzheng Song, Mengmeng Zheng, Junlin Wang, Huanhuan Liu, Zhi Lin, Bengbeng Liu, Zixin Deng, Qianghui Zhou, Xudong Qu, 2023 A pair of atypical KAS III homologues with initiation and elongation functions programs the polyketide biosynthesis in asukamycin, Xiaoli Yan, Jun Zhang, Hongqun Tan, Zhihao Liu, Kai Jiang, Wenya Tian, Mengmeng Zheng, Zhi Lin, Zixin Deng, Xudong Qu, 2022 An atypical acyl-CoA synthetase enables efficient biosynthesis of extender units for engineering a polyketide carbon scaffold, Mengmeng Zheng, Jun Zhang, Wan Zhang, Lu Yang, Xiaoli Yan, Wenya Tian, Zhihao Liu, Zhi Lin, Zixin Deng, Xudong Qu, 2022 A dual role reductase from phytosterol catabolism enables efficient production of valuable steroid precursors, Haidong Peng, Yaya Wang, Yanan Zhang, Zixing Deng, Zhenghua Tian, Xudong Qu, 2021 Molecular basis of regio- and stereo-specificity in biosynthesis of bacterial heterodimeric ketopiperazines, Chenghai Sun, Zhenyao Luo (co-first author), Wenlu Zhang, Wenya Tian, Haidong Peng, Zhi Lin, Xiaoli Yan, Yanan Zhang, Zixin Deng, Bostjan Kobe, Xinying Jia, Xudong Qu, 2020 Efficient biosynthesis of heterodimeric C3-aryl pyrroloindoline alkaloids, Wenya Tian, Chenghai Sun (co-first author), Mei Zheng, Mingjia Yu, Yanan Zhang, Haidong Peng, Dongqing Zhu, Jeffery Harmer, Zixin Deng, Shilu Chen, Mohedi Mobli, Xinying Jia, Xudong Qu, 2018 Uncovering the formation and selection of benzylmalonyl-CoA from the biosynthesis of splenocin and enterocin reveals a versatile way to introduce amino acids into Polyketide carbon scaffolds, Chengcheng Chang, Rong Huang (co-first author), Yan Yan, Hongmin Ma, Zheng Dai, Benying Zhang, Wen Liu, Zixin Deng, Xudong Qu, 2015

Areas of Focus

天然产物的定向生物合成

Publications

An unusual aromatase/cyclase programs the formation of the phenyldimethylanthrone framework in anthrabenzoxocinones and fasamycin, Kai Jiang, Xu Chen, Xiaoli Yan, Zixin Deng, Shunkun Luo, Xudong Qu, 2024
Engineering the substrate specificity of a P450 dimerase enables the collective biosynthesis of heterodimeric tryptophan-containing diketopiperazines, Chenghai Sun, Bao-Di Ma, Guangjun Li, Wenya Tian, Lu Yang, Haidong Peng, Zhi Lin, Zixin Deng, Xu-Dong Kong, Xudong Qu, 2023
A large conserved family of small-molecule carboxyl methyltransferases identified from microorganisms, Zhi Lin, Zhiwei Hu, Linjun Zhou, Benben Liu, Xiaowei Huang, Zixin Deng, Xudong Qu, 2023
A chemoenzymatic approach to C14-functionalized steroids, Fuzheng Song, Mengmeng Zheng, Junlin Wang, Huanhuan Liu, Zhi Lin, Bengbeng Liu, Zixin Deng, Qianghui Zhou, Xudong Qu, 2023
A pair of atypical KAS III homologues with initiation and elongation functions programs the polyketide biosynthesis in asukamycin, Xiaoli Yan, Jun Zhang, Hongqun Tan, Zhihao Liu, Kai Jiang, Wenya Tian, Mengmeng Zheng, Zhi Lin, Zixin Deng, Xudong Qu, 2022
An atypical acyl-CoA synthetase enables efficient biosynthesis of extender units for engineering a polyketide carbon scaffold, Mengmeng Zheng, Jun Zhang, Wan Zhang, Lu Yang, Xiaoli Yan, Wenya Tian, Zhihao Liu, Zhi Lin, Zixin Deng, Xudong Qu, 2022
A dual role reductase from phytosterol catabolism enables efficient production of valuable steroid precursors, Haidong Peng, Yaya Wang, Yanan Zhang, Zixing Deng, Zhenghua Tian, Xudong Qu, 2021
Molecular basis of regio- and stereo-specificity in biosynthesis of bacterial heterodimeric ketopiperazines, Chenghai Sun, Zhenyao Luo (co-first author), Wenlu Zhang, Wenya Tian, Haidong Peng, Zhi Lin, Xiaoli Yan, Yanan Zhang, Zixin Deng, Bostjan Kobe, Xinying Jia, Xudong Qu, 2020
Efficient biosynthesis of heterodimeric C3-aryl pyrroloindoline alkaloids, Wenya Tian, Chenghai Sun (co-first author), Mei Zheng, Mingjia Yu, Yanan Zhang, Haidong Peng, Dongqing Zhu, Jeffery Harmer, Zixin Deng, Shilu Chen, Mohedi Mobli, Xinying Jia, Xudong Qu, 2018
Uncovering the formation and selection of benzylmalonyl-CoA from the biosynthesis of splenocin and enterocin reveals a versatile way to introduce amino acids into Polyketide carbon scaffolds, Chengcheng Chang, Rong Huang (co-first author), Yan Yan, Hongmin Ma, Zheng Dai, Benying Zhang, Wen Liu, Zixin Deng, Xudong Qu, 2015

生物合成天然产物药物开发结构优化化学合成酶工程合成生物学聚酮生物碱类固醇药物

汪燕芳 - 同济大学

瞿旭东 - 上海交通大学

唐满成 - 上海交通大学

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