Professor | 杨雪瑞 | 数字化转型顾问

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Name	杨雪瑞
Contact Information	yangxuerui@tsinghua.edu.cn
Language ability	英语, 汉语
Province	北京

Upload Avatar (500 x 500)

Name

杨雪瑞

Contact Information

yangxuerui@tsinghua.edu.cn

Language ability

英语, 汉语

Province

北京

University/Lab Affiliation and Title	清华大学
Faculty	Life Sciences
Academic Background & Achievements	1999-2003 清华大学，化学工程系，学士 2003-2009 美国密歇根州立大学，化学工程系/生物化学及分子生物学系，双学科博士 2009-2012 美国哥伦比亚大学，Irving癌症研究中心，系统生物学联合中心，博士后
Work Experience	2012-至今副教授，清华大学生命科学学院

University/Lab Affiliation and Title

清华大学

Faculty

Life Sciences

Academic Background & Achievements

1999-2003 清华大学，化学工程系，学士
2003-2009 美国密歇根州立大学，化学工程系/生物化学及分子生物学系，双学科博士
2009-2012 美国哥伦比亚大学，Irving癌症研究中心，系统生物学联合中心，博士后

Work Experience

2012-至今副教授，清华大学生命科学学院

Areas of Focus	RNA生物信息学与癌症系统生物学多模态、跨尺度、多组学大数据的整合分析及多级调控网络与机制解析大规模复杂生物数据的深度学习工具开发翻译组学的系统、定量分析及翻译调控在肿瘤中的参与机制非编码转录组的系统分析与非编码RNA生物学功能的系统鉴定
Publications	Li, F., Fang, J., Yu, Y., Hao, S., Zou, Q., Zeng, Q., and Yang, X., Reanalysis of ribosome profiling datasets reveals a function of rocaglamide A in perturbing the dynamics of translation elongation via eIF4A. Nat Commun, 2023. 14(1): p. 553., 李, F., 方, J., 余, Y., 郝, S., 邹, Q., 曾, Q., 和杨, X., 2023 Hu, X., Zou, Q., Yao, L., and Yang, X., Survey of the binding preferences of RNA-binding proteins to RNA editing events. Genome Biol, 2022. 23(1): p. 169., 胡, X., 邹, Q., 姚, L., 和杨, X., 2022 Li, R. and Yang, X., De novo reconstruction of cell interaction landscapes from single-cell spatial transcriptome data with DeepLinc. Genome Biol, 2022. 23(1): p. 124., 李, R. 和杨, X., 2022 Wang, Y., Zou, Q., Li, F., Zhao, W., Xu, H., Zhang, W., Deng, H., and Yang, X., Identification of the cross-strand chimeric RNAs generated by fusions of bi-directional transcripts. Nat Commun, 2021. 12(1): p. 4645., 王, Y., 邹, Q., 李, F., 赵, W., 徐, H., 张, W., 邓, H., 和杨, X., 2021 Wang, X., Hu, X., Song, W., Xu, H., Xiao, Z., Huang, R., Bai, Q., Zhang, F., Chen, Y., Liu, Y., Fang, J., Li, X., Shen, Q., Zhao, H., and Yang, X., Mutual dependency between lncRNA LETN and protein NPM1 in controlling the nucleolar structure and functions sustaining cell proliferation. Cell Res, 2021. 31(6): p. 664-683., 王, X., 胡, X., 宋, W., 徐, H., 肖, Z., 黄, R., 白, Q., 张, F., 陈, Y., 刘, Y., 方, J., 李, X., 沈, Q., 赵, H., 和杨, X., 2021 Wang, X. and Yang, X., A Simple Blocking PCR-Based Method for the Synthesis of High-Copy dsDNA Tandem Repeats. Small, 2020: p. e2003671., 王, X. 和杨, X., 2020 Xu, F., Du, W., Zou, Q., Wang, Y., Zhang, X., Xing, X., Li, Y., Zhang, D., Wang, H., Zhang, W., Hu, X., Liu, X., Liu, X., Zhang, S., Yu, J., Fang, J., Li, F., Zhou, Y., Yue, T., Mi, N., Deng, H., Zou, P., Chen, X., Yang, X., and Yu, L., COPII mitigates ER stress by promoting formation of ER whorls. Cell Res, 2021. 31(2): p. 141-156., 徐, F., 杜, W., 邹, Q., 王, Y., 张, X., 邢, X., 李, Y., 张, D., 王, H., 张, W., 胡, X., 刘, X., 刘, X., 张, S., 余, J., 方, J., 李, F., 周, Y., 岳, T., 米, N., 邓, H., 邹, P., 陈, X., 杨, X., 和余, L., 2021 Zhu, M., Zou, Q., Huang, R., Li, Y., Xing, X., Fang, J., Ma, L., Li, L., Yang, X., and Yu, L., Lateral transfer of mRNA and protein by migrasomes modifies the recipient cells. Cell Res, 2021. 31(2): p. 237-240., 朱, M., 邹, Q., 黄, R., 李, Y., 邢, X., 方, J., 马, L., 李, L., 杨, X., 和余, L., 2021 Lin, Y., Li, F., Huang, L., Polte, C., Duan, H., Fang, J., Sun, L., Xing, X., Tian, G., Cheng, Y., Ignatova, Z., Yang, X., and Wolf, D.A., eIF3 Associates with 80S Ribosomes to Promote Translation Elongation, Mitochondrial Homeostasis, and Muscle Health. Mol Cell, 2020. 79(4): p. 575-587 e7., 林, Y., 李, F., 黄, L., Polte, C., 段, H., 方, J., 孙, L., 邢, X., 田, G., 程, Y., Ignatova, Z., 杨, X., 和 Wolf, D.A., 2020 Zou, Q., Xiao, Z., Huang, R., Wang, X., Wang, X., Zhao, H., and Yang, X., Survey of the translation shifts in hepatocellular carcinoma with ribosome profiling. Theranostics, 2019. 9(14): p. 4141-4155., 邹, Q., 肖, Z., 黄, R., 王, X., 王, X., 赵, H., 和杨, X., 2019

Areas of Focus

RNA生物信息学与癌症系统生物学
多模态、跨尺度、多组学大数据的整合分析及多级调控网络与机制解析
大规模复杂生物数据的深度学习工具开发
翻译组学的系统、定量分析及翻译调控在肿瘤中的参与机制
非编码转录组的系统分析与非编码RNA生物学功能的系统鉴定

Publications

Li, F., Fang, J., Yu, Y., Hao, S., Zou, Q., Zeng, Q., and Yang, X.*, Reanalysis of ribosome profiling datasets reveals a function of rocaglamide A in perturbing the dynamics of translation elongation via eIF4A. Nat Commun, 2023. 14(1): p. 553., 李, F., 方, J., 余, Y., 郝, S., 邹, Q., 曾, Q., 和杨, X.*, 2023
Hu, X., Zou, Q., Yao, L., and Yang, X.*, Survey of the binding preferences of RNA-binding proteins to RNA editing events. Genome Biol, 2022. 23(1): p. 169., 胡, X., 邹, Q., 姚, L., 和杨, X.*, 2022
Li, R. and Yang, X.*, De novo reconstruction of cell interaction landscapes from single-cell spatial transcriptome data with DeepLinc. Genome Biol, 2022. 23(1): p. 124., 李, R. 和杨, X.*, 2022
Wang, Y., Zou, Q., Li, F., Zhao, W., Xu, H., Zhang, W., Deng, H., and Yang, X.*, Identification of the cross-strand chimeric RNAs generated by fusions of bi-directional transcripts. Nat Commun, 2021. 12(1): p. 4645., 王, Y., 邹, Q., 李, F., 赵, W., 徐, H., 张, W., 邓, H., 和杨, X.*, 2021
Wang, X., Hu, X., Song, W., Xu, H., Xiao, Z., Huang, R., Bai, Q., Zhang, F., Chen, Y., Liu, Y., Fang, J., Li, X., Shen, Q., Zhao, H., and Yang, X.*, Mutual dependency between lncRNA LETN and protein NPM1 in controlling the nucleolar structure and functions sustaining cell proliferation. Cell Res, 2021. 31(6): p. 664-683., 王, X., 胡, X., 宋, W., 徐, H., 肖, Z., 黄, R., 白, Q., 张, F., 陈, Y., 刘, Y., 方, J., 李, X., 沈, Q., 赵, H., 和杨, X.*, 2021
Wang, X. and Yang, X.*, A Simple Blocking PCR-Based Method for the Synthesis of High-Copy dsDNA Tandem Repeats. Small, 2020: p. e2003671., 王, X. 和杨, X.*, 2020
Xu, F., Du, W., Zou, Q., Wang, Y., Zhang, X., Xing, X., Li, Y., Zhang, D., Wang, H., Zhang, W., Hu, X., Liu, X., Liu, X., Zhang, S., Yu, J., Fang, J., Li, F., Zhou, Y., Yue, T., Mi, N., Deng, H., Zou, P., Chen, X., Yang, X.*, and Yu, L.*, COPII mitigates ER stress by promoting formation of ER whorls. Cell Res, 2021. 31(2): p. 141-156., 徐, F., 杜, W., 邹, Q., 王, Y., 张, X., 邢, X., 李, Y., 张, D., 王, H., 张, W., 胡, X., 刘, X., 刘, X., 张, S., 余, J., 方, J., 李, F., 周, Y., 岳, T., 米, N., 邓, H., 邹, P., 陈, X., 杨, X.*, 和余, L.*, 2021
Zhu, M., Zou, Q., Huang, R., Li, Y., Xing, X., Fang, J., Ma, L., Li, L., Yang, X.*, and Yu, L.*, Lateral transfer of mRNA and protein by migrasomes modifies the recipient cells. Cell Res, 2021. 31(2): p. 237-240., 朱, M., 邹, Q., 黄, R., 李, Y., 邢, X., 方, J., 马, L., 李, L., 杨, X.*, 和余, L.*, 2021
Lin, Y., Li, F., Huang, L., Polte, C., Duan, H., Fang, J., Sun, L., Xing, X., Tian, G., Cheng, Y.*, Ignatova, Z., Yang, X.*, and Wolf, D.A.*, eIF3 Associates with 80S Ribosomes to Promote Translation Elongation, Mitochondrial Homeostasis, and Muscle Health. Mol Cell, 2020. 79(4): p. 575-587 e7., 林, Y., 李, F., 黄, L., Polte, C., 段, H., 方, J., 孙, L., 邢, X., 田, G., 程, Y.*, Ignatova, Z., 杨, X.*, 和 Wolf, D.A.*, 2020
Zou, Q., Xiao, Z., Huang, R., Wang, X., Wang, X., Zhao, H., and Yang, X.*, Survey of the translation shifts in hepatocellular carcinoma with ribosome profiling. Theranostics, 2019. 9(14): p. 4141-4155., 邹, Q., 肖, Z., 黄, R., 王, X., 王, X., 赵, H., 和杨, X.*, 2019

Rna 生物信息学癌症系统生物学数据整合深度学习翻译组学非编码Rna 翻译调控多组学

刘昱 - 上海交通大学

朱柳村 - 上海大学

冯畅 - 上海大学

Area of Focus
生物标志物 | 癌症 | 检测 | 诊断 | Dna | Rna | 放大 | 分子生物学 | 生物化学 | 临床研究

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